Primary Localized Laryngeal Amyloidosis (LA)

Abstract Abstract 4596 Background: Localized Laryngeal Amyloidosis (LA) is a rare condition. There is limited understanding of its natural history. Our aim is to report the clinical evolution of a patient diagnosed with localized LA. Methods: Case report. Results: In May 2002, a 43-year-old gentleman presented with hoarseness and a CT scan of the neck showed a thickening of the right vocal cord with a mass that measured 2.9 × 1.2 cm in widest diameter. The patient had this mass removed surgically and the pathology showed a positive Congo red staining and a positive birefringence under polarized light, diagnostic of amyloidosis. No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in this patient. Patient lost follow-up until October 2008 when he was found to have soft tissue induration around the left false vocal cord area. The biopsy showed again amyloidosis. Conclusions: LA recurrences can manifest several years after initial diagnosis. Long-term follow-up is essential. Disclosures: No relevant conflicts of interest to declare.

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Localized Laryngeal Amyloidosis

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1116 ◽

2016 ◽

Vol 6 (1) ◽

pp. 32-34

Author(s):

Gautam Khaund ◽

Ronica Baruah ◽

Abhijit Kalita

Keyword(s):

Head And Neck ◽

Vocal Cord ◽

Final Diagnosis ◽

Benign Disease ◽

Systemic Diseases ◽

Laryngeal Amyloidosis ◽

False Vocal ◽

Localized Laryngeal Amyloidosis

ABSTRACT Amyloidosis in head and neck is rare but a benign disease. Among the sites in head and neck, larynx is the most commonly involved. A 40-year-old female had presented with hoarseness of voice and dyspnea with a mass in false vocal cord, which was biopsied and diagnosed as amyloidosis. After excluding systemic diseases, final diagnosis of localized laryngeal amyloidosis was given. How to cite this article Baruah R, Khaund G, Kalita A. Localized Laryngeal Amyloidosis. Int J Phonosurg Laryngol 2016;6(1):32-34.

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Primary Localized Laryngeal Amyloidosis: Report of 3 Cases With Long-term Follow-up and Review of the Literature

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-215-pllaro ◽

2005 ◽

Vol 129 (2) ◽

pp. 215-218 ◽

Cited By ~ 1

Author(s):

Linglei Ma ◽

Bizhan Bandarchi ◽

Clarence Sasaki ◽

Steven Levine ◽

Young Choi

Keyword(s):

Light Chain ◽

Plasma Cells ◽

Anterior Commissure ◽

B Cell Lymphoma ◽

Plasma Cell Dyscrasia ◽

Laryngeal Amyloidosis ◽

Long Term Follow Up ◽

Localized Laryngeal Amyloidosis

Abstract Context.—Localized laryngeal amyloidosis is an uncommon condition with limited long-term follow-up studies. The precise etiology and pathogenesis are not entirely clear. Objective.—To further characterize the histopathologic features and possible pathogenesis of localized laryngeal amyloidosis. Design.—Three cases of primary localized laryngeal amyloidosis were identified at our institutions from 1980 to 2003. The clinical features and histologic and immunohistochemical patterns were evaluated. Systemic workups were pursued during the long-term follow-up. Results.—The common presentation of the patients was hoarseness. The lesions involved vocal cords, anterior commissure, and ventricle. Microscopically, the amyloid was present within the submucosa with an adjacent lymphoplasmacytic infiltrate. The plasma cells and amyloid demonstrated monoclonal light chain restriction in all 3 cases (2 λ, 1 κ). No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in these patients. Two patients with long-term follow-up underwent subsequent surgical removals for multiple recurrences, which occurred within 1 year of the initial diagnosis. Conclusions.—The demonstration of monoclonal light chain expression in the plasmacytic infiltrate and amyloid component in the absence of systemic lymphomas indicates that localized laryngeal amyloidosis may represent a form of benign monoclonal plasma cell dyscrasia. A close follow-up of the patients may be indicated for early detection of recurrences.

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Amyloidosis of the Larynx in a Child

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949410300802 ◽

1994 ◽

Vol 103 (8) ◽

pp. 590-594 ◽

Cited By ~ 16

Author(s):

Laurence R. O'Halloran ◽

Rodney P. Lusk

Keyword(s):

Vocal Cord ◽

Thyroid Cartilage ◽

Postoperative Recovery ◽

True Vocal Cord ◽

Vocal Process ◽

Laryngeal Amyloidosis ◽

Benign Process ◽

Vocal Quality ◽

False Vocal ◽

Localized Laryngeal Amyloidosis

Localized laryngeal amyloidosis is a rare and benign process. Only three cases have been reported in children. We present the case of a 9-year-old girl with localized laryngeal amyloidosis that was excised via laryngofissure. The patient presented with a 3- to 4-week history of progressive hoarseness. Direct laryngoscopy revealed a smooth, firm, submucosal mass extending from the anterior aspect of the left false vocal cord to the vocal process. Biopsy of the mass revealed findings consistent with amyloidosis. The mass was approached via laryngofissure and excised with the thyroid cartilage and left true vocal cord left intact. An extensive workup for systemic amyloidosis was negative, including bone marrow biopsy. The postoperative recovery was uneventful, with good vocal quality and a sluggish but mobile left true vocal cord. This case is significant because of the young age of the child, the extent of disease, and the use of laryngofissure for excision.

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Localized Laryngeal Amyloidosis

Otolaryngology ◽

10.1067/mhn.2002.129820 ◽

2002 ◽

Vol 127 (5) ◽

pp. 487-489 ◽

Cited By ~ 3

Author(s):

Aaron D. Friedman ◽

Rajendra Bhayani ◽

Lorenzo Memeo ◽

Daniel B. Kuriloff

Keyword(s):

Multiple Myeloma ◽

Polarized Light ◽

Vocal Folds ◽

Excisional Biopsy ◽

Body Sensation ◽

Laryngeal Amyloidosis ◽

False Vocal ◽

Work Up ◽

Localized Laryngeal Amyloidosis ◽

Hyaline Material

A 54-year-old female schoolteacher presented with 1-month of hoarseness and a foreign body sensation in the back of her throat that was not associated with symptoms or signs of infection. Direct laryngoscopy showed bilateral, yellow, hyperemic masses on the false vocal folds and laryngeal ventricles Fig 1 . Both true vocal folds were mobile. An excisional biopsy of the mass revealed an amorphous, eosinophilic hyaline material Fig 2 that exhibited apple-green birefringence when stained with Congo red and viewed under polarized light Fig 3 , consistent with amyloidosis. There was no evidence of neoplasm. The work-up for systemic amyloidosis and multiple myeloma was negative. The patient did well over the next several years, but recurrence of the laryngeal amyloid tumor necessitated 2 additional conservative endoscopic CO2 laser excisions. Since her last surgery, the patient has remained asymptomatic.

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Faculty Opinions recommendation of Long-term follow-up after surgery in localized laryngeal amyloidosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726341816.793518432 ◽

2016 ◽

Author(s):

Paul Pracy

Keyword(s):

Laryngeal Amyloidosis ◽

Long Term Follow Up ◽

Localized Laryngeal Amyloidosis

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Acute otitis media in an infant complicated with osteoarthritis of temporomandibular joint and sub-periosteal abscess of the clavicle

The Egyptian Journal of Otolaryngology ◽

10.1186/s43163-021-00123-8 ◽

2021 ◽

Vol 37 (1) ◽

Author(s):

Kaoutar Cherrabi ◽

Hind Cherrabi

Keyword(s):

Septic Arthritis ◽

Temporomandibular Joint ◽

Nutritional Assessment ◽

Acute Otitis Media ◽

Clinical Signs ◽

Rare Condition ◽

Pediatric Emergency ◽

Ear Infections ◽

The Right

Abstract Background Otomastoiditis is a very frequent affection and a current complication of mal-treated benign ear infections in children. However, this a very rare case of the association of two rare complications of otomastoiditis in a newborn. On the one hand, septic arthritis of the temporomandibular joint which is a very rare condition that is difficult to diagnose, and when unrecognized or not treated accordingly, it can resolve in serious infectious complication and or definitive injury to the temporomandibular joint. On the other hand, osteomyelitis of the clavicle is also very rare, and only a few cases have been cited in the literature concerning infants. Case presentation This 46-day-old infant was brought to pediatric emergency consultation for 2 swelling inflammatory bulges, one in the right mastoid and pre-auricular regions, and another in the right basi-cervical area. The infant was hypertrophic febrile, hypotonic, and pale. He had preserved archaic reflexes. Besides, blood test showed an inflammatory syndrome, inflammatory anemia, and no other abnormalities. Upon supplementary computed tomodensitometry exam, the diagnosis of a combination of septic arthritis of the right temporomandibular joint and sub-periosteal abscess of the ipsilateral clavicle in a context of hypotrophy and malnutrition was suspected. A pus sample was obtained for bacteriological evaluation, after which the infant had a course of intravenous associated antibiotics, along with nutritional assessment and management. Surgical drainage of both collections was performed. The 6-month follow-up was satisfactory, without clinical signs of functional impact on temporomandibular joint, or acromioclavicular joint. Conclusion This work stresses the necessity of thorough clinical examination of infants even in cases of benign ear infections, as well as the importance of adapted treatment and follow-up, which could allow early diagnosis, appropriate treatment, or even prevention of severe complications that can be associated with such benign conditions.

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Focus on localized laryngeal amyloidosis: management of five cases

Open Medicine ◽

10.1515/med-2020-0400 ◽

2020 ◽

Vol 15 (1) ◽

pp. 327-332

Author(s):

Massimo Mesolella ◽

Gerardo Petruzzi ◽

Sarah Buono ◽

Grazia Salerno ◽

Francesco Antonio Salzano ◽

...

Keyword(s):

Systemic Disease ◽

Clinical Aspects ◽

Benign Tumors ◽

Local Form ◽

Systemic Involvement ◽

Clinical Syndromes ◽

Laryngeal Amyloidosis ◽

And Control ◽

Localized Laryngeal Amyloidosis

AbstractAmyloidosis is a group of idiopathic clinical syndromes caused by the deposition of insoluble fibrillar proteins (amyloid) in the extracellular matrix of organs and tissues. These deposits disrupt the function of the target organ. Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO2 laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.

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A Case of Congenital Bronchial Pulmonary Arterial Malformation Successfully Treated by Embolization

Journal of Clinical Interventional Radiology ISVIR ◽

10.1055/s-0038-1676551 ◽

2018 ◽

Vol 02 (03) ◽

pp. 201-204

Author(s):

Ferdinand Chu ◽

Ko Sit ◽

King Kwok

Keyword(s):

Bronchial Artery ◽

Effective Means ◽

Rare Condition ◽

Embolic Material ◽

Right Pulmonary Artery ◽

Pulmonary Arterial ◽

The Right ◽

Arterial Malformation ◽

Right Bronchial Artery

AbstractIdiopathic bronchial pulmonary arterial malformation (BPAM) is a very rare condition. The authors present a case of BPAM in which a right bronchial artery communicates with a main upper lobe branch of the right pulmonary artery. It was successfully treated by embolization in one setting. The patient remained asymptomatic and well during the follow-up period. The authors therefore conclude that if the embolic material/device is carefully chosen, it is a safe and effective means of treating BPAM.

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Oncocytic cyst of the larynx: a rare finding

BMJ Case Reports ◽

10.1136/bcr-2018-227214 ◽

2019 ◽

Vol 12 (1) ◽

pp. bcr-2018-227214 ◽

Cited By ~ 1

Author(s):

Samantha Baird ◽

Halina Mann ◽

Cesar M Salinas-La Rosa ◽

Halil Ozdemir

Keyword(s):

Social History ◽

Granular Eosinophilic Cytoplasm ◽

Eosinophilic Cytoplasm ◽

Long Term Follow Up ◽

History Of ◽

The Right ◽

False Vocal ◽

Columnar Cells

A 75-year-old woman presented with an 18-month history of severe, slowly worsening dysphonia. She was a smoker and known to have multiple benign cystic thyroid lesions. She reported no associated symptoms and other medical and social history was unremarkable. Fibreoptic nasendoscopy revealed a right-sided supraglottic cyst appearing to arise from the right false vocal cord. Further bedside examination was unremarkable. She underwent microlaryngoscopy and biopsy which showed a cyst originating from the right anterior ventricle, successfully removed without rupture using cold steel. Formal histopathology revealed a 14×10×7 mm unilocular, completely excised cyst lined by oncocytic epithelium and composed of columnar cells with darkly stained nuclei and abundant granular, eosinophilic cytoplasm. Three weeks postoperatively the patient’s voice had returned to normal. To date, 11 months postoperatively, there is no evidence of recurrence, and she will continue long-term follow-up.

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