scholarly journals Milestones toward cochlear gene therapy for patients with hereditary hearing loss

2021 ◽  
Author(s):  
Hidekane Yoshimura ◽  
Shin‐Ya Nishio ◽  
Shin‐Ichi Usami
Keyword(s):  
Gene Therapy ◽  
Hearing Loss ◽  
Hereditary Hearing Loss

Gene therapy for hereditary hearing loss

2012 ◽  
Author(s):  
Abraham Matthias Sheffield
Keyword(s):  
Gene Therapy ◽  
Hearing Loss ◽  
Hereditary Hearing Loss

Gene Therapy for Hereditary Hearing Loss

2013 ◽  
Vol 17 (1) ◽  
pp. 5
Author(s):  
Devin S. McDougald ◽  
Lisa L. Cunningham ◽  
Wade W. Chien
Keyword(s):  
Gene Therapy ◽  
Hearing Loss ◽  
Hereditary Hearing Loss

scholarly journals Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing

Theranostics ◽  
2019 ◽  
Vol 9 (24) ◽  
pp. 7184-7199 ◽  
Author(s):  
Min-A Kim ◽  
Sung Huhn Kim ◽  
Nari Ryu ◽  
Ji-Hyun Ma ◽  
Ye-Ri Kim ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hearing Loss ◽  
Normal Hearing ◽  
Hereditary Hearing Loss ◽  
Functional Roles

Genetic etiology of hereditary hearing loss in the Gulf Cooperation Council countries

2021 ◽  
Author(s):  
Abdullah Al Mutery ◽  
Mona Mahfood ◽  
Jihen Chouchen ◽  
Abdelaziz Tlili
Keyword(s):  
Hearing Loss ◽  
Gulf Cooperation Council ◽  
Genetic Etiology ◽  
Hereditary Hearing Loss

scholarly journals Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art

2021 ◽  
Author(s):  
Aida Nourbakhsh ◽  
Brett M. Colbert ◽  
Eric Nisenbaum ◽  
Aziz El-Amraoui ◽  
Derek M. Dykxhoorn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Hearing Loss ◽  
Treatment Modalities ◽  
Versus Gene ◽  
Vitro Model ◽  
New Treatment ◽  
Induced Pluripotent ◽  
Therapy Strategies

AbstractProgressive non-syndromic sensorineural hearing loss (PNSHL) is the most common cause of sensory impairment, affecting more than a third of individuals over the age of 65. PNSHL includes noise-induced hearing loss (NIHL) and inherited forms of deafness, among which is delayed-onset autosomal dominant hearing loss (AD PNSHL). PNSHL is a prime candidate for genetic therapies due to the fact that PNSHL has been studied extensively, and there is a potentially wide window between identification of the disorder and the onset of hearing loss. Several gene therapy strategies exist that show potential for targeting PNSHL, including viral and non-viral approaches, and gene editing versus gene-modulating approaches. To fully explore the potential of these therapy strategies, a faithful in vitro model of the human inner ear is needed. Such models may come from induced pluripotent stem cells (iPSCs). The development of new treatment modalities by combining iPSC modeling with novel and innovative gene therapy approaches will pave the way for future applications leading to improved quality of life for many affected individuals and their families.

scholarly journals Carrier frequency of the GJB2 mutations that cause hereditary hearing loss in the Japanese population

2015 ◽  
Vol 60 (10) ◽  
pp. 613-617 ◽  
Author(s):  
Mirei Taniguchi ◽  
Hirotaka Matsuo ◽  
Seiko Shimizu ◽  
Akiyoshi Nakayama ◽  
Koji Suzuki ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Carrier Frequency ◽  
Japanese Population ◽  
Hereditary Hearing Loss ◽  
Gjb2 Mutations

scholarly journals Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss

2021 ◽  
Vol 21 ◽  
pp. 209-236
Author(s):  
Kamakshi Bankoti ◽  
Charles Generotti ◽  
Tiffany Hwa ◽  
Lili Wang ◽  
Bert W. O’Malley ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing

scholarly journals Perda auditiva genética

2003 ◽  
Vol 69 (1) ◽  
pp. 100-104 ◽  
Author(s):  
Ricardo Godinho ◽  
Ivan Keogh ◽  
Roland Eavey
Keyword(s):  
Hearing Loss ◽  
Home Page ◽  
Hereditary Hearing Loss

O progresso das pesquisas relacionadas à perda auditiva genética tem provocado um importante avanço do entendimento dos mecanismos moleculares que governam o desenvolvimento, a função, a resposta ao trauma e o envelhecimento do ouvido interno. Em países desenvolvidos, mais de 50% dos casos de surdez na infância é causada por alterações genéticas e as perdas auditivas relacionadas à idade têm sido associadas com mecanismos genéticos. OBJETIVO: O objetivo desta revisão é relatar as informações mais recentes relacionadas às perdas audtivas de origem genética. FORAMA DE ESTUDO: Revisão sistemática. MATERIAL E MÉTODO: A revisão da literatura inclui artigos indexados à MEDLINE (Biblioteca Nacional de Saúde, NIH-USA) e publicados nos últimos 3 anos, além das informações disponíveis na Hereditary Hearing Loss Home Page. CONCLUSÃO: Os recentes avanços no entendimento das perdas auditivas de origem genética têm favorecido a nossa compreensão da função auditiva e tornado o diagnóstico mais apurado. Possivelmente, no futuro, este conhecimento também proporcionará o desenvolvimento de novas terapias para o tratamento das causas genéticas das perdas auditivas.

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