scholarly journals Graft‐Versus‐Tumor Effect in Major Histocompatibility Complex–Mismatched Mouse Liver Transplantation

2019 ◽  
Vol 25 (8) ◽  
pp. 1251-1264
Author(s):  
Dongdong Yu ◽  
Lidong Wang ◽  
Tianchun Wu ◽  
Yaohui Zhang ◽  
Yang Tian ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Major Histocompatibility Complex ◽  
Mouse Liver ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Graft Versus Tumor Effect

scholarly journals Evidence for no relevance of anti-major histocompatibility complex class i-related chain a antibodies in liver transplantation

2008 ◽  
Vol 14 (12) ◽  
pp. 1793-1802 ◽  
Author(s):  
Mehmet Uzunel ◽  
Haxiaobieke Kasimu ◽  
Meghnad Joshi ◽  
Xupeng Ge ◽  
Jining Liu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver

Cell ◽  
1985 ◽  
Vol 41 (2) ◽  
pp. 469-478 ◽  
Author(s):  
J LALANNE ◽  
C TRANSY ◽  
S GUERIN ◽  
S DARCHE ◽  
P MEULIEN ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Mouse Liver ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Major Histocompatibility Complex Class I-related Chains A and B (MIC A/B): A Role in the Pathogenesis of Non-alcoholic Steatohepatitis

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
A Kahraman ◽  
S Menziletoglu Yildiz ◽  
M Schlattjan ◽  
A Kilicarslan ◽  
CD Fingas ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Alcoholic Steatohepatitis ◽  
Histocompatibility Complex

Relationship of Major Histocompatibility Complex Class II Genes to Inhibitor Antibody Formation in Hemophilia A

1990 ◽  
Vol 64 (04) ◽  
pp. 564-568 ◽  
Author(s):  
Lloyd E Lippert ◽  
Lyman Mc A Fisher ◽  
Lawrence B Schook
Keyword(s):  
Major Histocompatibility Complex ◽  
Factor Viii ◽  
Antibody Formation ◽  
Rflp Analysis ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Odds Ratios ◽  
Inhibitory Antibody ◽  
Histocompatibility Complex ◽  
Hla Dr

SummaryApproximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindII, PstI, PvuII and TaqI digested genomic DNA probed with DP beta, DQ alpha, DQ beta and DR beta class II MHC gene probes. The RFLP patterns for 16 non-inhibitor and 11 inhibitor hemophiliac patients were analyzed. These 24 enzyme:probe combinations generated 231 fragments. Fifteen (15) fragments associated with the inhibitor phenotype; odds ratios ranged from 5.1 to 45 and lower bounds of 95% confidence intervals were > 1.000 for all 15 fragments. Five (5) fragments associated with non-inhibitors, with odds ratios ranging from 6.4 to 51.7. This report establishes a MHC related genetic basis for the inhibitor phenotype. No statistically significant differences in the distribution of serologically defined HLA-DR phenotypes were observed between the inhibitor and non-inhibitor groups.

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