A Conjugated Polymer-Based Electrochemical DNA Sensor: Design and Application of a Multi-Functional and Water-Soluble Conjugated Polymer

2008 ◽  
Vol 29 (17) ◽  
pp. 1489-1494 ◽  
Author(s):  
Lanyong Zhang ◽  
Huan Sun ◽  
Di Li ◽  
Shiping Song ◽  
Chunhai Fan ◽  
...  
2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Hongliang Guan ◽  
Zhike He

Water-soluble fluorescent conjugated polymer is a promising material which could be used as an optical platform in highly sensitive molecular sensors. In this paper, a simple label-free DNA sensor, which consisted of a poly(3-alkoxy-4-methylthiophene) and an aptamer, was used to detect L-argininamide (L-Arm). Due to the specific binding reaction between L-Arm and its aptamer, the proposed method can easily determinate the L-Arm through the recovery of fluorescence without any modification. Other ions or similar molecules had little effect on the detection. Moreover, there was a linear relationship between fluorescence intensity and the concentration of L-Arm. The detection limit of L-Arm was as low as 4.7 nM.


2020 ◽  
Vol 167 (8) ◽  
pp. 087508 ◽  
Author(s):  
Luyen Thi Tran ◽  
Hoang Vinh Tran ◽  
Hue Thi Minh Dang ◽  
Chinh Dang Huynh ◽  
Tuan Anh Mai

2016 ◽  
Vol 49 (15) ◽  
pp. 5587-5598 ◽  
Author(s):  
Atul Kumar Dwivedi ◽  
Ravinder Singh ◽  
Ashutosh Singh ◽  
Kung-Hwa Wei ◽  
Chu-Ya Wu ◽  
...  

2018 ◽  
Vol 265 ◽  
pp. 514-521 ◽  
Author(s):  
Sakda Jampasa ◽  
Weena Siangproh ◽  
Rawiwan Laocharoensuk ◽  
Pattamawadee Yanatatsaneejit ◽  
Tirayut Vilaivan ◽  
...  

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3489 ◽  
Author(s):  
Yurii Kuzin ◽  
Dominika Kappo ◽  
Anna Porfireva ◽  
Dmitry Shurpik ◽  
Ivan Stoikov ◽  
...  

Voltammetric DNA sensor has been proposed on the platform of glassy carbon electrode covered with carbon black with adsorbed pillar[5]arene molecules. Electropolymerization of Neutral Red performed in the presence of native or oxidatively damaged DNA resulted in formation of hybrid material which activity depended on the DNA conditions. The assembling of the surface layer was confirmed by scanning electron microscopy and electrochemical impedance spectroscopy. The influence of DNA and pillar[5]arene on redox activity of polymeric dye was investigated and a significant increase of the peak currents was found for DNA damaged by reactive oxygen species generated by Cu2+/H2O2 mixture. Pillar[5]arene improves the electron exchange conditions and increases the response and its reproducibility. The applicability of the DNA sensor developed was shown on the example of ascorbic acid as antioxidant. It decreases the current in the concentration range from 1.0 μM to 1.0 mM. The possibility to detect antioxidant activity was qualitatively confirmed by testing tera infusion. The DNA sensor developed can find application in testing of carcinogenic species and searching for new antitumor drugs.


2019 ◽  
Vol 5 (2) ◽  
pp. 313-319 ◽  
Author(s):  
Qiaojuan Gong ◽  
Haixia Han ◽  
Haiying Yang ◽  
Meiling Zhang ◽  
Xiaoling Sun ◽  
...  

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