Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells

2005 ◽  
Vol 43 (4) ◽  
pp. 207-214 ◽  
Author(s):  
Jenq-Chang Lee ◽  
Ming-Chei Maa ◽  
Hsiu-Shan Yu ◽  
Jung-Hui Wang ◽  
Chia-Kuang Yen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells

2004 ◽  
Vol 67 (1) ◽  
pp. 135-146 ◽  
Author(s):  
Hong-Gang Yu ◽  
Henning Schrader ◽  
Jan-Michel Otte ◽  
Wolfgang E Schmidt ◽  
Frank Schmitz
Keyword(s):  
Colon Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Tyrosine Phosphorylation ◽  
Focal Adhesion ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity

2020 ◽  
Vol 21 (10) ◽  
pp. 3420
Author(s):  
Shinan Li ◽  
Trong Thuan Ung ◽  
Thi Thinh Nguyen ◽  
Dhiraj Kumar Sah ◽  
Seon Young Park ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nadph Oxidase ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Cell Invasion ◽  
Human Colon ◽  
Ros Production ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Matrix metalloproteinase-9 (MMP-9) plays a crucial role in cell invasion and cancer metastasis. In this study, we showed that cholic acid (CA), a major primary bile acid, can induce MMP-9 expression in colon cancer HT29 and SW620 cells. CA increased reactive oxygen species (ROS) production and also activated phosphorylation of ERK1/2, JNK, and p38 MAPK. Specific inhibitors and mutagenesis studies showed that ERK1/2 and JNK functioned as upstream signals in the activation of AP-1, and p38 MAPK functioned as an upstream signal in the activation of NF-κB. N-acetyl-L-cysteine (NAC, an ROS scavenger) and diphenyleneiodonium chloride (DPI, an NADPH oxidase inhibitor) inhibited CA-induced activation of ERK1/2, JNK, and p38 MAPK, indicating that ROS production by NADPH oxidase could be the furthest upstream signal in MMP-9 expression. Colon cancer cells pretreated with CA showed remarkably enhanced invasiveness. Such enhancement was partially abrogated by MMP-9-neutralizing antibodies. These results demonstrate that CA could induce MMP-9 expression via ROS-dependent ERK1/2, JNK-activated AP-1, and p38-MAPK-activated NF-κB signaling pathways, which in turn stimulate cell invasion in human colon cancer cells.

Leptin induces cell invasion and the upregulation of matrilysin in human colon cancer cells

BioMedicine ◽  
2013 ◽  
Vol 3 (4) ◽  
pp. 174-180 ◽  
Author(s):  
Meng-Chiu Lin ◽  
Shu-Yao Tsai ◽  
Fu-Yu Wang ◽  
Fu-Hsuan Liu ◽  
Jia-Ning Syu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cell Invasion ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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