Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9

2015 ◽  
Vol 55 (7) ◽  
pp. 1127-1137 ◽  
Author(s):  
Haiyu Zhang ◽  
Chunyan Hao ◽  
Yang Wang ◽  
Shufang Ji ◽  
Xiaoli Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Human Ovarian Cancer Cell ◽  
Transcriptional Inactivation

The role of miR-205 in the VEGF-mediated promotion of human ovarian cancer cell invasion

2015 ◽  
Vol 137 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Juanni Li ◽  
Long Li ◽  
Zexia Li ◽  
Guanghui Gong ◽  
Puxiang Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Human Ovarian Cancer Cell

Fibroblasts Stimulate Human Ovarian Cancer Cell Invasion and Expression of 72-kDa Gelatinase A (MMP-2)

1997 ◽  
Vol 67 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Anna Westerlund ◽  
Erkki Hujanen ◽  
Ulla Puistola ◽  
Taina Turpeenniemi-Hujanen
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Gelatinase A ◽  
Cancer Cell Invasion ◽  
Human Ovarian Cancer Cell

Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadherin expression

FEBS Letters ◽  
2014 ◽  
Vol 588 (21) ◽  
pp. 3998-4007 ◽  
Author(s):  
Wai-Kin So ◽  
Qianlan Fan ◽  
Man-Tat Lau ◽  
Xin Qiu ◽  
Jung-Chien Cheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Human Ovarian Cancer Cell ◽  
E Cadherin

scholarly journals COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion

2014 ◽  
Vol 21 (4) ◽  
pp. 533-543 ◽  
Author(s):  
Xin Qiu ◽  
Jung-Chien Cheng ◽  
Hsun-Ming Chang ◽  
Peter C K Leung
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Human Ovarian Cancer Cell ◽  
Cox2 Expression ◽  
E Cadherin

Elevated expression of cyclooxygenase 2 (COX2 (PTGS2)) has been reported to occur in human ovarian cancer and to be associated with poor prognosis. We have previously demonstrated that COX2-derived prostaglandin E2 (PGE2) promotes human ovarian cancer cell invasion. We had also demonstrated that epidermal growth factor (EGF) induces human ovarian cancer cell invasion by downregulating the expression of E-cadherin through various signaling pathways. However, it remains unclear whether COX2 and PGE2 are involved in the EGF-induced downregulation of E-cadherin expression and cell invasion in human ovarian cancer cells. In this study, we showed that EGF treatment induces COX2 expression and PGE2 production in SKOV3 and OVCAR5 human ovarian cancer cell lines. Interestingly, COX2 is not required for the EGF-induced downregulation of E-cadherin expression. In addition, EGF treatment activates the phosphatidylinositol-3-kinase (PI3K)/Akt and cAMP response element-binding protein (CREB) signaling pathways, while only the PI3K/Akt pathway is involved in EGF-induced COX2 expression. Moreover, we also showed that EGF-induced cell invasion is attenuated by treatment with a selective COX2 inhibitor, NS-398, as well as PGE2 siRNA. This study demonstrates an important role for COX2 and its derivative, PGE2, in the mediation of the effects of EGF on human ovarian cancer cell invasion.

CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression

2019 ◽  
Vol 518 (3) ◽  
pp. 416-422 ◽  
Author(s):  
Ning Luo ◽  
Dan-dan Chen ◽  
Li Liu ◽  
Li Li ◽  
Zhong-ping Cheng
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Human Ovarian Cancer Cell

scholarly journals CC Chemokine Ligand 7 Derived from Cancer-Stimulated Macrophages Promotes Ovarian Cancer Cell Invasion

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2745
Author(s):  
Miran Jeong ◽  
Yi-Yue Wang ◽  
Ju-Yeon Choi ◽  
Myong-Cheol Lim ◽  
Jung-Hye Choi
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Cancer Cell Invasion ◽  
Cc Chemokine ◽  
Chemokine Ligand

In the tumor microenvironment, macrophages have been suggested to be stimulated by tumor cells, becoming tumor-associated macrophages that promote cancer development and progression. We examined the effect of these macrophages on human ovarian cancer cell invasion and found that conditioned medium of macrophages stimulated by ovarian cancer cells (OC-MQs) significantly increased cell invasion. CC chemokine ligand 7 (CCL7) expression and production were significantly higher in OC-MQs than in the control macrophages. Peritoneal macrophages from patients with ovarian cancer showed higher CCL7 expression levels than those from healthy controls. Inhibition of CCL7 using siRNA and neutralizing antibodies reduced the OC-MQ-CM-induced ovarian cancer cell invasion. CC chemokine receptor 3 (CCR3) was highly expressed in human ovarian cancer cells, and a specific inhibitor of this receptor reduced the OC-MQ-CM-induced invasion. Specific signaling and transcription factors were associated with enhanced CCL7 expression in OC-MQs. CCL7-induced invasion required the expression of matrix metalloproteinase 9 via activation of extracellular signal-related kinase signaling in human ovarian cancer cells. These data suggest that tumor-associated macrophages can affect human ovarian cancer metastasis via the CCL7/CCR3 axis.

scholarly journals MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α

2013 ◽  
Vol 133 (4) ◽  
pp. 867-878 ◽  
Author(s):  
Yu-Ming Yeh ◽  
Chi-Mu Chuang ◽  
Kuan-Chong Chao ◽  
Lu-Hai Wang
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

scholarly journals β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis

2009 ◽  
Vol 106 (8) ◽  
pp. 2806-2811 ◽  
Author(s):  
Laura Rosanò ◽  
Roberta Cianfrocca ◽  
Stefano Masi ◽  
Francesca Spinella ◽  
Valeriana Di Castro ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Endothelin A Receptor ◽  
Endothelin A
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