The homeodomain transcription factor MEIS1 triggers chemokine expression and is involved in CD8+ T-lymphocyte infiltration in early stage ovarian cancer

2018 ◽  
Vol 57 (9) ◽  
pp. 1251-1263 ◽  
Author(s):  
Athanasios Karapetsas ◽  
Maria Tokamani ◽  
Christos Evangelou ◽  
Raphael Sandaltzopoulos
Keyword(s):  
Ovarian Cancer ◽  
Transcription Factor ◽  
T Lymphocyte ◽  
Early Stage ◽  
Lymphocyte Infiltration ◽  
Homeodomain Transcription Factor ◽  
Chemokine Expression ◽  
Cd8 T Lymphocyte ◽  
Early Stage Ovarian Cancer

scholarly journals Overexpression ofGPC6andTMEM132Din Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Athanasios Karapetsas ◽  
Antonis Giannakakis ◽  
Denarda Dangaj ◽  
Evripidis Lanitis ◽  
Spyridon Kynigopoulos ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
T Lymphocyte ◽  
Early Stage ◽  
Mrna Levels ◽  
Lymphocyte Infiltration ◽  
Ovarian Cancer Cell Lines ◽  
Cd8 T Lymphocyte ◽  
Genes Encoding ◽  
Early Stage Ovarian Cancer

Infiltration of cytotoxic T-lymphocytes in ovarian cancer is a favorable prognostic factor. Employing a differential expression approach, we have recently identified a number of genes associated with CD8+ T-cell infiltration in early stage ovarian tumors. In the present study, we validated by qPCR the expression of two genes encoding the transmembrane proteins GPC6 and TMEM132D in a cohort of early stage ovarian cancer patients. The expression of both genes correlated positively with the mRNA levels ofCD8A, a marker of T-lymphocyte infiltration [Pearson coefficient: 0.427 (p=0.0067) and 0.861 (p<0.0001), resp.].GPC6andTMEM132Dexpression was also documented in a variety of ovarian cancer cell lines. Importantly, Kaplan-Meier survival analysis revealed that high mRNA levels of GPC6 and/or TMEM132D correlated significantly with increased overall survival of early stage ovarian cancer patients(p=0.032). Thus,GPC6andTMEM132Dmay serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis, prognosis, and tumor immunobattling.

scholarly journals Comparison of the survival outcomes of laparoscopy versus laparotomy in treatment of early-stage ovarian cancer: a systematic review and meta-analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Qingduo Kong ◽  
Hongyi Wei ◽  
Jing Zhang ◽  
Yilin Li ◽  
Yongjun Wang
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Early Stage ◽  
Meta Analysis ◽  
Progression Free Survival ◽  
Cochrane Library ◽  
Survival Outcomes ◽  
Free Survival ◽  
Review Manager ◽  
Early Stage Ovarian Cancer

Abstract Background Laparoscopy has been widely used for patients with early-stage epithelial ovarian cancer (eEOC). However, there is limited evidence regarding whether survival outcomes of laparoscopy are equivalent to those of laparotomy among patients with eEOC. The result of survival outcomes of laparoscopy is still controversial. The aim of this meta-analysis is to analyze the survival outcomes of laparoscopy versus laparotomy in the treatment of eEOC. Methods According to the keywords, Pubmed, Embase, Cochrane Library and Clinicaltrials.gov were searched for studies from January 1994 to January 2021. Studies comparing the efficacy and safety of laparoscopy versus laparotomy for patients with eEOC were assessed for eligibility. Only studies including outcomes of overall survival (OS) were enrolled. The meta-analysis was performed using Stata software (Version 12.0) and Review Manager (Version 5.2). Results A total of 6 retrospective non-random studies were included in this meta-analysis. The pooled results indicated that there was no difference between two approaches for patients with eEOC in OS (HR = 0.6, P = 0.446), progression-free survival (PFS) (HR = 0.6, P = 0.137) and upstaging rate (OR = 1.18, P = 0.54). But the recurrence rate of laparoscopic surgery was lower than that of laparotomic surgery (OR = 0.48, P = 0.008). Conclusions Laparoscopy and laparotomy appear to provide comparable overall survival and progression-free survival outcomes for patients with eEOC. Further high-quality studies are needed to enhance this statement.

Clinical Picture of Women with Early Stage Ovarian Cancer

2001 ◽  
Vol 81 (2) ◽  
pp. 337 ◽  
Author(s):  
Gamal H. Eltabbakh ◽  
Pramila R. Yadev ◽  
Ann Morgan
Keyword(s):  
Ovarian Cancer ◽  
Clinical Picture ◽  
Early Stage ◽  
Early Stage Ovarian Cancer

OCaMIR - A noninvasive, diagnostic signature for early stage ovarian cancer: a multi-cohort retrospective and prospective study

2021 ◽  
pp. clincanres.0267.2021
Author(s):  
Raju Kandimalla ◽  
Wei Wang ◽  
Fan Yu ◽  
Nianxin Zhou ◽  
Feng Gao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prospective Study ◽  
Early Stage ◽  
Diagnostic Signature ◽  
Early Stage Ovarian Cancer

A Risk-Adapted Strategy of Adjuvant Paclitaxel/Carboplatin in Early-Stage Ovarian Cancer: Time-Dependent Effect of 4 versus 6 Cycles on Outcome

Oncology ◽  
2011 ◽  
Vol 81 (5-6) ◽  
pp. 365-371 ◽  
Author(s):  
Aristotle Bamias ◽  
Christina Bamia ◽  
Alexandra Karadimou ◽  
Nikolaos Soupos ◽  
Flora Zagouri ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Time Dependent ◽  
Dependent Effect ◽  
Time Dependent Effect ◽  
Early Stage Ovarian Cancer

Early-Stage Ovarian Cancer

2014 ◽  
pp. 1-6
Author(s):  
Behrouz Zand ◽  
Ralph S. Freedman
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Early Stage Ovarian Cancer
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