Thyroglobulin as a negative marker for malignancy in canine and human breast tumors

2021 ◽  
Author(s):  
Sung‐Hyun Hwang ◽  
Yeseul Yang ◽  
Sang‐Ho Woo ◽  
Jae‐Ha Jung ◽  
Dansong Seo ◽  
...  
Keyword(s):  
Breast Tumors ◽  
Human Breast ◽  
Negative Marker

Characterization of CTL Recognized Epitopes on Human Breast Tumors

2000 ◽  
Author(s):  
Constantin G. Ioannides
Keyword(s):  
Breast Tumors ◽  
Human Breast

scholarly journals Defining bad stroma in human breast tumors

Cell Cycle ◽  
2011 ◽  
Vol 10 (18) ◽  
pp. 3056-3056
Author(s):  
Anthony Howell
Keyword(s):  
Breast Tumors ◽  
Human Breast

Glucosiduronidation of androsterone by human breast tumors in vitro in relation to the progesterone receptor content

Steroids ◽  
1983 ◽  
Vol 42 (4) ◽  
pp. 449-455 ◽  
Author(s):  
Uma Raju ◽  
Mortimer Levitz ◽  
Alexander Kaganowicz ◽  
Ancel Blaustein
Keyword(s):  
Progesterone Receptor ◽  
Breast Tumors ◽  
Human Breast

Estrone and estradiol content in human breast tumors: Relationship to estradiol receptors

1977 ◽  
Vol 8 (8) ◽  
pp. 893-896 ◽  
Author(s):  
Jack Fishman ◽  
Jerome S. Nisselbaum ◽  
Celia J. Menendez-Botet ◽  
Morton K. Schwartz
Keyword(s):  
Breast Tumors ◽  
Human Breast ◽  
Estradiol Receptors

scholarly journals MEK inhibition leads to lysosome-mediated Na+/I− symporter protein degradation in human breast cancer cells

2013 ◽  
Vol 20 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Zhaoxia Zhang ◽  
Sasha Beyer ◽  
Sissy M Jhiang
Keyword(s):  
Breast Cancer ◽  
Cell Surface ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Breast Tumors ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Iodide Uptake ◽  
Mek Inhibition ◽  
Protein Levels

The Na+/I−symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. NIS-mediated iodide uptake in thyroid cells is the basis for targeted radionuclide imaging and treatment of differentiated thyroid carcinomas and their metastases. Furthermore, NIS is expressed in many human breast tumors but not in normal non-lactating breast tissue, suggesting that NIS-mediated radionuclide uptake may also allow the imaging and targeted therapy of breast cancer. However, functional cell surface NIS expression is often low in breast cancer, making it important to uncover signaling pathways that modulate NIS expression at multiple levels, from gene transcription to posttranslational processing and cell surface trafficking. In this study, we investigated NIS regulation in breast cancer by MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) signaling, an important cell signaling pathway involved in oncogenic transformation. We found that MEK inhibition decreased NIS protein levels in all-trans retinoic acid/hydrocortisone-treated MCF-7 cells as well as human breast cancer cells expressing exogenous NIS. The decrease in NIS protein levels by MEK inhibition was not accompanied by a decrease inNISmRNA or a decrease inNISmRNA export from the nucleus to the cytoplasm. NIS protein degradation upon MEK inhibition was prevented by lysosome inhibitors but not by proteasome inhibitors. Interestingly, NIS protein level was correlated with MEK/ERK activation in human breast tumors from a tissue microarray. Taken together, MEK activation appears to play an important role in maintaining NIS protein stability in human breast cancers.

Immunocytochemical localization of insulin- and somatostatin-like material in human breast tumors

Life Sciences ◽  
1984 ◽  
Vol 35 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Elinor J. Spring-Mills ◽  
Susan B. Stearns ◽  
Patricia J. Numann ◽  
Phillip H. Smith
Keyword(s):  
Breast Tumors ◽  
Immunocytochemical Localization ◽  
Human Breast

scholarly journals Androgen and vitamin D receptor expression in archival human breast tumors

Cytometry ◽  
2004 ◽  
Vol 58B (1) ◽  
pp. 53-60 ◽  
Author(s):  
Awtar Krishan ◽  
Poonam Arya ◽  
Parvin Ganjei-Azar ◽  
Suzanne E. Shirley ◽  
Carlos T. Escoffery ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Breast Tumors ◽  
Receptor Expression ◽  
Human Breast
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