Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol-ester—type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: A permissive role for the arachidonic acid cascade in signal transduction

1993 ◽  
Vol 7 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Hyunah L. Yoon ◽  
Craig B. Marcus ◽  
Richard W. Pfeifer
Keyword(s):  
Signal Transduction ◽  
Arachidonic Acid ◽  
Phorbol Ester ◽  
Peritoneal Macrophages ◽  
Tumor Promoter ◽  
Arachidonic Acid Cascade ◽  
B6c3f1 Mice ◽  
Permissive Role

Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages

1988 ◽  
Vol 971 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Kazuo Ohuchi ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
Tsuneo Ozeki ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism ◽  
Tumor Promoter

The Arachidonic Acid Cascade, Eicosanoids, and Signal Transduction

1994 ◽  
Vol 733 (1 Molecular and) ◽  
pp. 325-334 ◽  
Author(s):  
U. JANßEN-TIMMEN ◽  
I. TOMIÇ ◽  
E. SPECHT ◽  
U. BEILECKE ◽  
A. J. R. HABENICHT
Keyword(s):  
Signal Transduction ◽  
Arachidonic Acid ◽  
Arachidonic Acid Cascade

scholarly journals Ligated complement receptors do not activate the arachidonic acid cascade in resident peritoneal macrophages.

1985 ◽  
Vol 161 (3) ◽  
pp. 617-622 ◽  
Author(s):  
A A Aderem ◽  
S D Wright ◽  
S C Silverstein ◽  
Z A Cohn
Keyword(s):  
Arachidonic Acid ◽  
Peritoneal Macrophages ◽  
Complement Receptors ◽  
Arachidonic Acid Cascade ◽  
Coated Particles ◽  
Intracellular Signals ◽  
C3 Receptors

Receptors for IgG stimulate the release of approximately 20% of cellular arachidonic acid (20:4) from murine resident peritoneal macrophages. In contrast, C3 receptors do not trigger the secretion of any 20:4 in excess of that released constitutively from the cells. Since the ability of C3 receptors to promote phagocytosis is regulated, we compared resting macrophages, whose C3 receptors do not promote phagocytosis of C3-coated particles, and lymphokine-treated cells, whose receptors do promote ingestion. Despite their ability to promote phagocytosis, the C3 receptor of lymphokine-treated macrophages remain unable to initiate release of 20:4. We speculate that the intracellular signals that initiate phagocytosis are distinct from those that initiate release of 20:4.

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