Stimulatory effect of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal cell proliferation in vivo as compared to the effects of phorbol ester TPA

1991 ◽  
Vol 12 (8) ◽  
pp. 1491-1497 ◽  
Author(s):  
Friedrich Marks ◽  
Brigitte Hanke ◽  
Ole Thastrup ◽  
Gerhard Fürstenberger
Keyword(s):  
Cell Proliferation ◽  
Arachidonic Acid ◽  
Epidermal Cell ◽  
Phorbol Ester ◽  
Acid Metabolism ◽  
Arachidonic Acid Metabolism ◽  
Tumor Promoter ◽  
Epidermal Cell Proliferation

Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages

1988 ◽  
Vol 971 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Kazuo Ohuchi ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
Tsuneo Ozeki ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Peritoneal Macrophages ◽  
Arachidonic Acid Metabolism ◽  
Tumor Promoter

The molecular biology of mammalian arachidonic acid metabolism

1991 ◽  
Vol 260 (2) ◽  
pp. L13-L28 ◽  
Author(s):  
E. Sigal
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Recombinant Dna ◽  
Biological Activities ◽  
Biological Effects ◽  
Arachidonic Acid Metabolism ◽  
Bioactive Metabolites ◽  
Wide Range

The metabolism of arachidonic acid by cyclooxygenase and lipoxygenase enzymes results in a wide range of oxidized products with potent biological activities. These metabolites, which include the prostaglandins and leukotrienes, have been implicated in the pathogenesis of a variety of inflammatory diseases. Research over the last decade has focused primarily on the elucidation of the chemical structure of the metabolites and their biological effects in vitro and in vivo. Recently, research on the enzymes that produce these bioactive metabolites through oxidization of arachidonic acid has intensified. Recombinant DNA techniques have enabled investigators to determine the nucleotide sequences for several of the enzymes in the arachidonic acid cascade. The resulting cDNAs are now being used to further investigate the biochemical and biological features of arachidonic acid metabolism. The purpose of this paper is to review how the cDNAs for these enzymes were obtained, what information they convey, and how they are being applied in current research.

Effect of in vivo coal dust exposure on arachidonic acid metabolism in the rat alveolar macrophage

1990 ◽  
Vol 29 (2) ◽  
pp. 157-168 ◽  
Author(s):  
Douglas C. Kuhn ◽  
Charles F. Stanley ◽  
Nadia El‐Ayouby ◽  
Laurence M. Demers
Keyword(s):  
Arachidonic Acid ◽  
Alveolar Macrophage ◽  
Acid Metabolism ◽  
Coal Dust ◽  
Arachidonic Acid Metabolism ◽  
Dust Exposure
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