scholarly journals Blinded versus unblinded evaluations of motor scores in patients with Parkinson's disease randomized to deep brain stimulation or best medical therapy.

2020 ◽  
Author(s):  
Gun‐Marie Hariz ◽  
Anna Fredricks ◽  
Rasmus Stenmark‐Persson ◽  
Marwan Hariz ◽  
Lars Forsgren ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Best Medical Therapy ◽  
Deep Brain

scholarly journals Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial

2010 ◽  
Vol 9 (6) ◽  
pp. 581-591 ◽  
Author(s):  
Adrian Williams ◽  
Steven Gill ◽  
Thelekat Varma ◽  
Crispin Jenkinson ◽  
Niall Quinn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Open Label ◽  
Advanced Parkinson’S Disease ◽  
Open Label Trial ◽  
Best Medical Therapy ◽  
Deep Brain

scholarly journals The cost-effectiveness of deep brain stimulation in combination with best medical therapy, versus best medical therapy alone, in advanced Parkinson’s disease

2013 ◽  
Vol 261 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Simon Eggington ◽  
Francesc Valldeoriola ◽  
K. Ray Chaudhuri ◽  
Keyoumars Ashkan ◽  
Elena Annoni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cost Effectiveness ◽  
Deep Brain Stimulation ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Advanced Parkinson’S Disease ◽  
Best Medical Therapy ◽  
The Cost ◽  
Deep Brain

scholarly journals Subthalamic deep brain stimulation versus best medical therapy for l-dopa responsive pain in Parkinson’s disease

Pain ◽  
2013 ◽  
Vol 154 (8) ◽  
pp. 1477-1479 ◽  
Author(s):  
Oguzkan Sürücü ◽  
Heide Baumann-Vogel ◽  
Mechtild Uhl ◽  
Lukas L. Imbach ◽  
Christian R. Baumann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Best Medical Therapy ◽  
Deep Brain

scholarly journals Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models

2019 ◽  
Vol 116 (52) ◽  
pp. 26259-26265 ◽  
Author(s):  
Jerrold L. Vitek ◽  
Luke A. Johnson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Functional Organization ◽  
Surgical Approaches ◽  
Drug Induced ◽  
Deep Brain

Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder affecting over 10 million people worldwide. In the 1930s and 1940s there was little understanding regarding what caused PD or how to treat it. In a desperate attempt to improve patients’ lives different regions of the neuraxis were ablated. Morbidity and mortality were common, but some patients’ motor signs improved with lesions involving the basal ganglia or thalamus. With the discovery ofl-dopa the advent of medical therapy began and surgical approaches became less frequent. It soon became apparent, however, that medical therapy was associated with side effects in the form of drug-induced dyskinesia and motor fluctuations and surgical therapies reemerged. Fortunately, during this time studies in monkeys had begun to lay the groundwork to understand the functional organization of the basal ganglia, and with the discovery of the neurotoxin MPTP a monkey model of PD had been developed. Using this model scientists were characterizing the physiological changes that occurred in the basal ganglia in PD and models of basal ganglia function and dysfunction were proposed. This work provided the rationale for the return of pallidotomy, and subsequently deep brain stimulation procedures. In this paper we describe the evolution of these monkey studies, how they provided a greater understanding of the pathophysiology underlying the development of PD and provided the rationale for surgical procedures, the search to understand mechanisms of DBS, and how these studies have been instrumental in understanding PD and advancing the development of surgical therapies for its treatment.

scholarly journals Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Gerson Suarez-Cedeno ◽  
Jessika Suescun ◽  
Mya C. Schiess
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Therapeutic Benefit ◽  
Current Application ◽  
Fda Approval ◽  
Best Medical Therapy ◽  
Disease Stages ◽  
Deep Brain

Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson’s disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy. In 2013 the EARLY-STIM trial provided Class I evidence for the use of DBS earlier in Parkinson’s disease. This finding led to the most recent FDA approval in patients with at least 4 years of disease duration and 4 months of motor complications as an adjunct therapy for patients not adequately controlled with medications. This following review highlights the historical development and advances made overtime in DBS implantation, the current application, and the challenges that come with it.

Medical therapy and subthalamic deep brain stimulation in advanced Parkinson's disease: a different long-term outcome?

2013 ◽  
Vol 85 (5) ◽  
pp. 552-559 ◽  
Author(s):  
A. Merola ◽  
L. Rizzi ◽  
M. Zibetti ◽  
C. A. Artusi ◽  
E. Montanaro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Medical Therapy ◽  
Brain Stimulation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Advanced Parkinson’S Disease ◽  
Deep Brain
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