In this paper, we study two kinds of fractional differential systems with multi-orders. One is a system of fractional differential equations with multi-order, [Formula: see text], [Formula: see text]; the other is a multi-order fractional differential equation, [Formula: see text]. By the derived technique, such two kinds of fractional differential equations can be changed into equations with the same fractional orders providing that the multi-orders are rational numbers, so the known theorems of existence, uniqueness and dependence upon initial conditions are easily applied. And asymptotic stability theorems for their associate linear systems, [Formula: see text], [Formula: see text], and [Formula: see text], [Formula: see text], [Formula: see text], are also derived.