Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o -quinone-dependent Nrf2 activation by a catechol-type resveratrol analog

2015 ◽  
Vol 59 (12) ◽  
pp. 2395-2406 ◽  
Author(s):  
Dong Lin ◽  
Fang Dai ◽  
Lan-Di Sun ◽  
Bo Zhou
Keyword(s):  
Cancer Chemoprevention ◽  
Nrf2 Activation ◽  
Catechol Moiety

scholarly journals Chemoprevention of cancer: current evidence and future prospects

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 916 ◽  
Author(s):  
Vassiliki Benetou ◽  
Areti Lagiou ◽  
Pagona Lagiou
Keyword(s):  
Cancer Chemoprevention ◽  
Present Review ◽  
Current Evidence ◽  
Future Prospects ◽  
Chemopreventive Agents ◽  
Long Latency ◽  
The Future ◽  
Vegetables And Fruits ◽  
Genetic Profiles

Cancer chemoprevention refers to the use of agents for the inhibition, delay, or reversal of carcinogenesis before invasion. In the present review, agents examined in the context of cancer chemoprevention are classified in four major categories—hormonal, medications, diet-related agents, and vaccines—and the main representatives of each category are presented. Although there are serious constraints in the documentation of effectiveness of chemopreventive agents, mainly stemming from the long latency of the condition they are addressing and the frequent lack of intermediate biomarkers, there is little disagreement about the role of aspirin, whereas a diet rich in vegetables and fruits appears to convey more protection than individual micronutrients. Among categories of cancer chemopreventive agents, hormonal ones and vaccines might hold more promise for the future. Also, the identification of individuals who would benefit most from chemopreventive interventions on the basis of their genetic profiles could open new prospects for cancer chemoprevention.

scholarly journals Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells

2008 ◽  
Vol 121 (5) ◽  
pp. 1255-1261.e7 ◽  
Author(s):  
Hyon-Jeen Kim ◽  
Berenice Barajas ◽  
Meiying Wang ◽  
Andre E. Nel
Keyword(s):  
Dendritic Cells ◽  
Age Related ◽  
Nrf2 Activation

scholarly journals Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation

Redox Biology ◽  
2018 ◽  
Vol 14 ◽  
pp. 609-617 ◽  
Author(s):  
Yuguang Zhao ◽  
Wenjing Song ◽  
Zhenyu Wang ◽  
Zongqiang Wang ◽  
Xing Jin ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Nrf2 Activation

Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

2014 ◽  
Vol 73 ◽  
pp. 95-104 ◽  
Author(s):  
Jing Jin ◽  
Tianqin Xiong ◽  
Xiangyu Hou ◽  
Xiaozhe Sun ◽  
Jiayi Liao ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Nrf2 Activation
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