Dietary Alpha‐Ketoglutarate Promotes Epithelial Metabolic Transition and Protects against DSS‐Induced Colitis

2021 ◽  
Vol 65 (7) ◽  
pp. 2000936
Author(s):  
Qiyu Tian ◽  
Alejandro Bravo Iniguez ◽  
Qi Sun ◽  
Hongbin Wang ◽  
Min Du ◽  
...  
Keyword(s):  
2007 ◽  
Vol 21 (4) ◽  
pp. 258-264 ◽  
Author(s):  
Camila A.M. de Oliveira ◽  
Eliete Luciano ◽  
Maria Cristina C.G. Marcondes ◽  
Maria Alice R. de Mello

1998 ◽  
Vol 84 (10) ◽  
pp. 777-782 ◽  
Author(s):  
C. F. Fioravanti ◽  
D. J. Walker ◽  
P. S. Sandhu

2011 ◽  
Vol 76 (1-2) ◽  
pp. 1-18 ◽  
Author(s):  
Nir Dai ◽  
Shahar Cohen ◽  
Vitaly Portnoy ◽  
Galil Tzuri ◽  
Rotem Harel-Beja ◽  
...  

2021 ◽  
Vol 35 (10) ◽  
Author(s):  
Mauricio Castro‐Sepúlveda ◽  
Béatrice Morio ◽  
Mauro Tuñón‐Suárez ◽  
Sebastian Jannas‐Vela ◽  
Francisco Díaz‐Castro ◽  
...  

2010 ◽  
Vol 63 (3) ◽  
pp. 443-457 ◽  
Author(s):  
Jane L. Ward ◽  
Silvia Forcat ◽  
Manfred Beckmann ◽  
Mark Bennett ◽  
Sonia J. Miller ◽  
...  

2003 ◽  
Vol 90 (5-6) ◽  
pp. 520-525 ◽  
Author(s):  
Elmarie Terblanche ◽  
Werner A. Cloete ◽  
Pieter A. L. du Plessis ◽  
Jacques N. Sadie ◽  
Annemie Strauss ◽  
...  

Blood ◽  
2010 ◽  
Vol 115 (23) ◽  
pp. 4742-4749 ◽  
Author(s):  
Connie M. Krawczyk ◽  
Thomas Holowka ◽  
Jie Sun ◽  
Julianna Blagih ◽  
Eyal Amiel ◽  
...  

Abstract Dendritic cells (DCs) are key regulators of innate and acquired immunity. The maturation of DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and other pattern recognition receptors. Here, we demonstrate that, in mouse DCs, TLR agonists stimulate a profound metabolic transition to aerobic glycolysis, similar to the Warburg metabolism displayed by cancer cells. This metabolic switch depends on the phosphatidyl inositol 3′-kinase/Akt pathway, is antagonized by the adenosine monophosphate (AMP)–activated protein kinase (AMPK), and is required for DC maturation. The metabolic switch induced by DC activation is antagonized by the antiinflammatory cytokine interleukin-10. Our data pinpoint TLR-mediated metabolic conversion as essential for DC maturation and function and reveal it as a potential target for intervention in the control of excessive inflammation and inappropriately regulated immune responses.


2014 ◽  
Vol 26 ◽  
pp. 87-97 ◽  
Author(s):  
Anke Schaffartzik ◽  
Andreas Mayer ◽  
Simone Gingrich ◽  
Nina Eisenmenger ◽  
Christian Loy ◽  
...  

2004 ◽  
Vol 46 (1) ◽  
pp. 123-134 ◽  
Author(s):  
Sonal S. Sheth ◽  
Lawrence W. Castellani ◽  
Soumya Chari ◽  
Cory Wagg ◽  
Christopher K. Thipphavong ◽  
...  

2011 ◽  
Vol 15 (6) ◽  
pp. 877-892 ◽  
Author(s):  
Fridolin Krausmann ◽  
Simone Gingrich ◽  
Reza Nourbakhch‐Sabet
Keyword(s):  

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