Robust mixed electron-photon radiation therapy optimization

2019 ◽  
Vol 46 (3) ◽  
pp. 1384-1396
Author(s):  
Marc-André Renaud ◽  
Monica Serban ◽  
Jan Seuntjens
Keyword(s):  
Radiation Therapy ◽  
Photon Radiation ◽  
Electron Photon

Ion chamber and film‐based quality assurance of mixed electron‐photon radiation therapy

2021 ◽  
Author(s):  
Veng Jean Heng ◽  
Monica Serban ◽  
Jan Seuntjens ◽  
Marc‐André Renaud
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Photon Radiation ◽  
Ion Chamber ◽  
Electron Photon

On mixed electron–photon radiation therapy optimization using the column generation approach

2017 ◽  
Vol 44 (8) ◽  
pp. 4287-4298 ◽  
Author(s):  
Marc‐André Renaud ◽  
Monica Serban ◽  
Jan Seuntjens
Keyword(s):  
Radiation Therapy ◽  
Column Generation ◽  
Photon Radiation ◽  
Electron Photon

scholarly journals Predicted Rates of Secondary Malignancies From Proton Versus Photon Radiation Therapy for Stage I Seminoma

2012 ◽  
Vol 82 (1) ◽  
pp. 242-249 ◽  
Author(s):  
Charles B. Simone ◽  
Kevin Kramer ◽  
William P. O’Meara ◽  
Justin E. Bekelman ◽  
Arnaud Belard ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Stage I ◽  
Photon Radiation ◽  
Secondary Malignancies ◽  
Stage I Seminoma

scholarly journals National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer

2017 ◽  
Vol 97 (1) ◽  
pp. 128-137 ◽  
Author(s):  
Kristin A. Higgins ◽  
Kelli O'Connell ◽  
Yuan Liu ◽  
Theresa W. Gillespie ◽  
Mark W. McDonald ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Photon Radiation ◽  
National Cancer Database ◽  
Small Cell Lung ◽  
Database Analysis

scholarly journals A case report of total skin photon radiation therapy for cutaneous epitheliotropic lymphoma in a dog

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Michael A. Deveau ◽  
Megan Sutton ◽  
Courtney Baetge ◽  
Alison B. Diesel
Keyword(s):  
Veterinary Medicine ◽  
Radiation Therapy ◽  
Treatment Time ◽  
Treatment Interruption ◽  
Photon Radiation ◽  
Beam Radiation ◽  
Palliative Intent ◽  
Time Commitment ◽  
Cutaneous Lymphomas ◽  
Grade 3

Abstract Background Total skin electron beam radiation therapy (TSEBT) is an effective treatment for primary diffuse cutaneous lymphomas in humans. While several techniques exist, they all require significant commitment of staff time and resources. In veterinary medicine, canine-specific techniques and strategies have been adapted and delivered but deemed not “realistically” clinically implementable given the time commitment of over 2.5 h plus per fraction or have been relegated to palliative intent. Leveraging these technologies of helical tomotherapy and 3D printing, we developed and clinically implemented a radiotherapeutic treatment strategy for the management of medically refractory diffuse cutaneous lymphoma in the dog. Case presentation A 13.5-year-old female spayed Bichon Frise presented to the Oncology service at Texas A&M University, College of Veterinary Medicine due to the progression of diffuse cutaneous epitheliotropic lymphoma (CEL) that had failed medical management. Twenty-seven gray were delivered to the patient with a treatment time requirement under 40 min including real time monitoring of anesthesia during setup and treatment. A partial response was noticeable after four fractions and the tumor completely regressed progressively over the entire treated area by the end of therapy. A grade 1 lethargy, fatigue, weight loss, and oral mucositis and grade 2 alopecia, nail/claw changes, pruritus, scaling, anorexia, and diarrhea were noted during treatment. Additionally, a grade 3 thrombocytopenia developed after fraction eight requiring a treatment interruption of 6 weeks and prescription modification prior to treatment continuation and completion. From the beginning of total skin photon radiation therapy (TSPT) treatment until the time of the patient was euthanized unrelated to cutaneous epitheliotropic lymphoma (123 days), only one new lesion on the head was identified and confirmed by histopathology within the treated fields. Conclusions The proposed technique is an acceptable alternative to TSEBT that is actually clinically implementable within a palliative or definitive setting and clinical constraints, however further testing and refinement is needed to reduce hematological complications and to confirm and expand on preliminary findings.

scholarly journals Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity

2019 ◽  
Vol 20 (17) ◽  
pp. 4148 ◽  
Author(s):  
Toshiaki Matsui ◽  
Endang Nuryadi ◽  
Shuichiro Komatsu ◽  
Yuka Hirota ◽  
Atsushi Shibata ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Predictive Biomarkers ◽  
Photon Radiation ◽  
Published Data ◽  
Gold Standard Method ◽  
Clonogenic Assays ◽  
Survival Endpoints ◽  
Number Of Publications

Photon radiation therapy is a major curative treatment for cancer. However, the lack of robust predictive biomarkers for radiosensitivity precludes personalized radiation therapy. Clonogenic assays are the gold standard method for measuring the radiosensitivity of cancer cells. Although a large number of publications describe the use of clonogenic assays to measure cancer cell radiosensitivity, the robustness of results from different studies is unclear. To address this, we conducted a comprehensive detailed literature search of 256 common cancer cell lines and identified the eight cell lines most-frequently examined for photon sensitivity using clonogenic assays. Survival endpoints and experimental parameters from all 620 relevant experiments were compiled and analyzed. We found that the coefficients of variation for SF2 (surviving fraction after 2 Gy irradiation) and for D10 (dose that yields a surviving fraction of 10%) were below 30% for all cell lines, indicating that SF2 and D10 have acceptable inter-assay precision. These data support further analysis of published data on clonogenic assays using SF2 and D10 as survival endpoints, which facilitates robust identification of biological profiles representative of cancer cell sensitivity to photons.

scholarly journals Risk of Visual Toxicity Following Fractionated Proton vs Photon Radiation Therapy for Patients with Meningiomas

2018 ◽  
Vol 102 (3) ◽  
pp. e204
Author(s):  
A.J. Bishop ◽  
K.T. Tran ◽  
P.K. Allen ◽  
A. Mahajan ◽  
M.F. McAleer ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Photon Radiation

scholarly journals A Comparison of Grade 4 Lymphopenia with Proton versus Photon Radiation Therapy for Esophageal Cancer

2018 ◽  
Vol 102 (3) ◽  
pp. e41
Author(s):  
D.M. Routman ◽  
A. Garant ◽  
S.C. Lester ◽  
C.N. Day ◽  
C.T. Sanhueza ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Photon Radiation

10 Results of 90 Gy proton/photon radiation therapy for glioblastoma multiforme

1997 ◽  
Vol 39 (2) ◽  
pp. 139 ◽  
Author(s):  
Markus Fitzek ◽  
Allan Thornton ◽  
James Rabenow ◽  
Michael Lev ◽  
Francisco Pardo ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Glioblastoma Multiforme ◽  
Photon Radiation

The Main Directions of Clinical Application of Modern Proton Therapy

2019 ◽  
pp. 41-51
Author(s):  
А. Самойлов ◽  
A. Samoylov ◽  
Ж. Смирнова ◽  
Zh. Smirnova ◽  
В. Климанов ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Application ◽  
Proton Therapy ◽  
Clinical Studies ◽  
Photon Radiation ◽  
Proton Radiation ◽  
Proton Radiation Therapy ◽  
Current State ◽  
The Cost

This paper analyzes the current state of clinical application of proton radiation therapy (PRT) for the treatment of cancer. In particular, the indications for the use of PRT for the treatment of specific pathologies, the results and condition of randomized clinical studies of PRT compared to photon radiation therapy (PhRT) are considered, the cost of PRT is compared with the cost of PhRT. The focus is on discussing the results of PRT using in advanced countriesand Russia for the treatment of several common tumor sites. In the conclusion of the work, the ways of further improvement of radiobiology, dose delivering technology and dosimetric support of PRT are considered.

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