Review of the book 'Understanding radiation biology. from DNA damage to cancer and radiation risk’ best regards

Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations

Cancers ◽

10.3390/cancers12040799 ◽

2020 ◽

Vol 12 (4) ◽

pp. 799 ◽

Cited By ~ 3

Author(s):

Konstantinos P. Chatzipapas ◽

Panagiotis Papadimitroulas ◽

Dimitris Emfietzoglou ◽

Spyridon A. Kalospyros ◽

Megumi Hada ◽

...

Keyword(s):

Dna Damage ◽

Monte Carlo ◽

Ionizing Radiation ◽

Monte Carlo Simulations ◽

High Energy ◽

Radiation Biology ◽

Medical Procedures ◽

Promising Tool ◽

Need To Evaluate ◽

Mc Simulation

Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are widely used when dosimetry is the matter of investigation. The scientific community has invested, over the last 20 years, a lot of effort into improving the knowledge of radiation biology. The present article aims to summarize the understanding of the field of DNA damage response (DDR) to ionizing radiation by providing an overview on MC simulation studies that try to explain several aspects of radiation biology. The need for accurate techniques for the quantification of DNA damage is crucial, as it becomes a clinical need to evaluate the outcome of various applications including both low- and high-energy radiation medical procedures. Understanding DNA repair processes would improve radiation therapy procedures. Monte Carlo simulations are a promising tool in radiobiology studies, as there are clear prospects for more advanced tools that could be used in multidisciplinary studies, in the fields of physics, medicine, biology and chemistry. Still, lot of effort is needed to evolve MC simulation tools and apply them in multiscale studies starting from small DNA segments and reaching a population of cells.

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