Relevance Assessments for Web Search Evaluation: Should We Randomise or Prioritise the Pooled Documents?

In the context of depth- k pooling for constructing web search test collections, we compare two approaches to ordering pooled documents for relevance assessors: The prioritisation strategy (PRI) used widely at NTCIR, and the simple randomisation strategy (RND). In order to address research questions regarding PRI and RND, we have constructed and released the WWW3E8 dataset, which contains eight independent relevance labels for 32,375 topic-document pairs, i.e., a total of 259,000 labels. Four of the eight relevance labels were obtained from PRI-based pools; the other four were obtained from RND-based pools. Using WWW3E8, we compare PRI and RND in terms of inter-assessor agreement, system ranking agreement, and robustness to new systems that did not contribute to the pools. We also utilise an assessor activity log we obtained as a byproduct of WWW3E8 to compare the two strategies in terms of assessment efficiency. Our main findings are: (a) The presentation order has no substantial impact on assessment efficiency; (b) While the presentation order substantially affects which documents are judged (highly) relevant, the difference between the inter-assessor agreement under the PRI condition and that under the RND condition is of no practical significance; (c) Different system rankings under the PRI condition are substantially more similar to one another than those under the RND condition; and (d) PRI-based relevance assessment files (qrels) are substantially and statistically significantly more robust to new systems than RND-based ones. Finding (d) suggests that PRI helps the assessors identify relevant documents that affect the evaluation of many existing systems, including those that did not contribute to the pools. Hence, if researchers need to evaluate their current IR systems using legacy IR test collections, we recommend the use of those constructed using the PRI approach unless they have a good reason to believe that their systems retrieve relevant documents that are vastly different from the pooled documents. While this robustness of PRI may also mean that the PRI-based pools are biased against future systems that retrieve highly novel relevant documents, one should note that there is no evidence that RND is any better in this respect.

Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease

Hexanucleotide G4C2 repeat expansions in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) generated by translation of repeat-containing RNAs show toxic effects in vivo as well as in vitro and are key targets for therapeutic intervention. We generated human antibodies that bind DPRs with high affinity and specificity. Anti-GA antibodies engaged extra- and intracellular poly-GA and reduced aggregate formation in a poly-GA over-expressing human cell line. However, antibody treatment in human neuronal cultures synthesizing exogenous poly-GA resulted in the formation of large extracellular immune complexes and did not affect accumulation of intracellular poly-GA aggregates. Treatment with antibodies was also shown to directly alter the morphological and biochemical properties of poly-GA and to shift poly-GA/antibody complexes to more rapidly sedimenting ones. These alterations were not observed with poly-GP and have important implications for accurate measurement of poly-GA levels including the need to evaluate all centrifugation fractions and disrupt the interaction between treatment antibodies and poly-GA by denaturation. Targeting poly-GA and poly-GP in two mouse models expressing G4C2 repeats by systemic antibody delivery for up to 16 months was well-tolerated and led to measurable brain penetration of antibodies. Long term treatment with anti-GA antibodies produced improvement in an open field movement test in aged C9ORF72450 mice. However, chronic administration of anti-GA antibodies in AAV-(G4C2)149 mice was associated with increased levels of poly-GA detected by immunoassay and did not significantly reduce poly-GA aggregates or alleviate disease progression in this model.

Cervical Spine Inhomogeneously Enhancing Lesion: Avoiding Confirmation Bias

Confirmation bias is the tendency to seek information and evidence in order to confirm a preexisting hypothesis while giving less importance and overlook an alternative solution. This report describes the case of a 52-year-old man with a long history of neck pain and bilateral upper limbs paresthesias with a cervical intracanal inhomogeneously enhancing lesion. Despite all the preoperative radiological findings, a spinal meningioma an anterior approach was performed. The mass ended up being a large migrated hernia with the involvement of two levels. Before suggesting treatment, especially surgery, physicians and practitioners need to evaluate all of the possible alternatives in order to optimize patient outcome.

Evaluation of the technical capacity of artisans to fabricate the animal-powered direct seeder super-eco in Sénégal.

This study focused on the ability of local Senegalese artisans to fabricate the animal-powered no-till (NT) direct seeder Super-Eco to reduce the expensive import of seeders. Technical specifications and design of the animal-powered direct seeder Super-Eco were first given to 90 heads of artisanal workshops in three regions of the Southern Peanut Basin for them to reproduce the machine. Detailed information on their workshop equipment was collected in advance. A principal component analysis (PCA) was then used to classify artisan workshops. The results showed that Class 3 was very well equipped and was able to fabricate the direct seeder. It was followed by Class 2 which was fairly well equipped, but was only able to develop 90% of the seeder parts. Because of a low level of equipment, the third class of artisans was only capable of fabricating very few pieces of the seeder. Artisans from Class 3 were able to fully construct the animal-powered direct seeder. However, it was noted that the other classes of artisans were able to reproduce some parts of the animal-powered direct seeder Super-Eco but they could not make the seeder box with its nested seed metering device due to their low level of equipment. They instead buy it from the Sahelian Industrial Company of Mechanics, Agricultural Materials and Representations or from traders. The need to evaluate the performance of the seeders developed by local artisans is also noted.

A Mini Review on SARS-COVID-19-2 Omicron Variant (B.1.1.529)

The current world facing unpredictable problems with different variants of COVID-19; SARS-COV-19 is a significant lung infection caused by a coronavirus. Each type has one or more alterations to distinguish from each other. The viruses, including SARS-COV-19, continuously change the genetic code (mutations) during their genome replication. WHO labelled two variants in that we are experienced with delta (B.1.617.2) variant, now recently the omicron came (B.1.1.529) with highly mutatable strikes on it. So WHO predicted it is more dangerous than previous variants because of its mutatable capability. The mutatable strikes play an essential role in transmissibility. So there is a need to evaluate threatens raised with the new variant, so scientists are working on it. Till now, South Africa noticed major cases positive for the Omicron variant. Based on recent reports, the current paper summarized different properties of the omicron variant with others, including protein structure, diagnosis, spreadability, treatment, and potency of vaccines. Doi: 10.28991/SciMedJ-2021-0304-10 Full Text: PDF

EVALUATION OF THE CULTURAL SPHERE BUDGETARY FINANCING AT THE SUBNATIONAL LEVEL IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT IN UKRAINE

One of the components of the sustainable economic development strategy of Ukraine is the reform of the state policy in the cultural sphere (CS). The implementation of a set of measures in this direction involves modification of the current model of budgetary financing of cultural activities at the national and subnational levels. In view of this, there is a need to evaluate the budgeting situation of the CS in a regional context and identify its peculiarities in the context of modern requirements that arose in connection with the realization of the sustainable development strategy of the Ukrainian economy. This involves the formation of scientific and methodological approaches to assessing the budgetary financing of the CS at the subnational level from the point of view of changing the imperative of Ukraine’s development.

Current Research Evaluation Topics in Social Sciences

The social sciences, as a collection of scholarly fields, have quite different characteristics compared to STEM (science, technology, engineering, and medicine) fields. Still, researchers in the social sciences have been evaluated similarly to researchers in STEM for many years. However, many studies have been published regarding the need to evaluate social sciences differently. This chapter examines research evaluation studies published in social sciences and presents the advantages and disadvantages of current research evaluation topics including altmetrics, content-based citation analysis, peer-review, and scientific visualization

Effectiveness of community-based livestock protection strategies: a case study of human–lion conflict mitigation

Conservation scientists are increasingly recognizing the need to evaluate the effectiveness of interventions to improve human–wildlife coexistence across different contexts. Here we assessed the long-term efficacy of the Long Shields Community Guardians programme in Zimbabwe. This community-based programme seeks to protect livestock and prevent depredation by lions Panthera leo through non-lethal means, with the ultimate aim of promoting human–lion coexistence. Using a quasi-experimental approach, we measured temporal trends in livestock depredation by lions and the prevalence of retaliatory killing of lions by farmers and wildlife managers. Farmers that were part of the Long Shields programme experienced a significant reduction in livestock loss to lions, and the annual number of lions subject to retaliatory killing by farmers dropped by 41% since the start of the programme in 2013, compared to 2008–2012, before the programme was initiated. Our findings demonstrate the Long Shields programme can be a potential model for limiting livestock depredation by lions. More broadly, our study demonstrates the effectiveness of community-based interventions to engage community members, improve livestock protection and ameliorate levels of retaliatory killing, thereby reducing human–lion conflict.

Urban aerosol chemistry at a land–water transition site during summer – Part 2: Aerosol pH and liquid water content

Particle acidity (aerosol pH) is an important driver of atmospheric chemical processes and the resulting effects on human and environmental health. Understanding the factors that control aerosol pH is critical when enacting control strategies targeting specific outcomes. This study characterizes aerosol pH at a land–water transition site near Baltimore, MD, during summer 2018 as part of the second Ozone Water-Land Environmental Transition Study (OWLETS-2) field campaign. Inorganic fine-mode aerosol composition, gas-phase NH3 measurements, and all relevant meteorological parameters were used to characterize the effects of temperature, aerosol liquid water (ALW), and composition on predictions of aerosol pH. Temperature, the factor linked to the control of NH3 partitioning, was found to have the most significant effect on aerosol pH during OWLETS-2. Overall, pH varied with temperature at a rate of −0.047 K−1 across all observations, though the sensitivity was −0.085 K−1 for temperatures > 293 K. ALW had a minor effect on pH, except at the lowest ALW levels (< 1 µg m−3), which caused a significant increase in aerosol acidity (decrease in pH). Aerosol pH was generally insensitive to composition (SO42-, SO42-:NH4+, total NH3 (Tot-NH3) = NH3 + NH4+), consistent with recent studies in other locations. In a companion paper, the sources of episodic NH3 events (95th percentile concentrations, NH3 > 7.96 µg m−3) during the study are analyzed; aerosol pH was higher by only ∼ 0.1–0.2 pH units during these events compared to the study mean. A case study was analyzed to characterize the response of aerosol pH to nonvolatile cations (NVCs) during a period strongly influenced by primary Chesapeake Bay emissions. Depending on the method used, aerosol pH was estimated to be either weakly (∼ 0.1 pH unit change based on NH3 partitioning calculation) or strongly (∼ 1.4 pH unit change based on ISORROPIA thermodynamic model predictions) affected by NVCs. The case study suggests a strong pH gradient with size during the event and underscores the need to evaluate assumptions of aerosol mixing state applied to pH calculations. Unique features of this study, including the urban land–water transition site and the strong influence of NH3 emissions from both agricultural and industrial sources, add to the understanding of aerosol pH and its controlling factors in diverse environments.

A world of viruses nested within parasites: Unraveling viral diversity within parasitic flatworms (Platyhelminthes)

Because parasites have an inextricable relationship with their host, they have the potential to serve as viral reservoirs or facilitate virus host-shifts. Yet, little is known about viruses infecting parasitic hosts except for blood-feeding arthropods that are well-known vectors of zoonotic viruses. Herein we uncover viruses of flatworms (Phylum Platyhelminthes, group Neodermata) that specialize in parasitizing vertebrates and their ancestral free-living relatives. We discovered 115 novel viral sequences, including 1 in Macrostomorpha, 5 in Polycladida, 44 in Tricladida, 1 in Monogenea, 15 in Cestoda and 49 in Trematoda, through data mining. The majority of newly identified viruses constitute novel families or genera. Phylogenetic analyses show that the virome of flatworms changed dramatically during the transition of Neodermatans to a parasitic lifestyle. Most Neodermatan viruses seem to co-diversify with their host , with the exception of rhabdoviruses which may switch host more often, based on phylogenetic relationships. Neodermatan rhabodviruses also have an ancestral position to vertebrate-associated viruses, including Lyssaviruses, suggesting that vertebrate rhabdoviruses emerged from a flatworm rhabdovirus in a parasitized host. This study reveals an extensive diversity of viruses in Platyhelminthes and highlights the need to evaluate the role of viral infection in flatworm-associated diseases.