A high‐Z inorganic scintillator–based detector f or time‐resolved in vivo dosimetry during brachytherapy

2021 ◽  
Author(s):  
Erik B. Jørgensen ◽  
Jacob G. Johansen ◽  
Joakim Overgaard ◽  
Dominique Piché‐Meunier ◽  
Daline Tho ◽  
...  
Keyword(s):  
In Vivo Dosimetry ◽  
Time Resolved ◽  
Inorganic Scintillator

Dwell time verification in brachytherapy based on time resolved in vivo dosimetry

2019 ◽  
Vol 60 ◽  
pp. 156-161
Author(s):  
J.G. Johansen ◽  
G. Kertzscher ◽  
E.B. Jørgensen ◽  
S. Rylander ◽  
L. Bentzen ◽  
...  
Keyword(s):  
Dwell Time ◽  
In Vivo Dosimetry ◽  
Time Resolved

Time-resolved in vivo dosimetry for source tracking in brachytherapy

Brachytherapy ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 122-132 ◽  
Author(s):  
Jacob Graversen Johansen ◽  
Susanne Rylander ◽  
Simon Buus ◽  
Lise Bentzen ◽  
Steffen Bjerre Hokland ◽  
...  
Keyword(s):  
In Vivo Dosimetry ◽  
Source Tracking ◽  
Time Resolved

scholarly journals Advances on inorganic scintillator-based optic fiber dosimeters

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Liang Ding ◽  
Qiong Wu ◽  
Qun Wang ◽  
Yamei Li ◽  
Richard M. Perks ◽  
...  
Keyword(s):  
Real Time ◽  
Electromagnetic Interference ◽  
Light Output ◽  
In Vivo Dosimetry ◽  
X Ray ◽  
Inorganic Scintillator ◽  
Ion Chamber ◽  
Advantages And Disadvantages ◽  
Depth Dose

Abstract This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scintillator-based optical fiber dosimeters (SFD) are compact, free of electromagnetic interference, radiation-resistant, and robust. They have shown great potential for real-time in vivo RTD. Compared with organic scintillators (OSs), inorganic scintillators (IOSs) have larger X-ray absorption and higher light output. Variable IOSs with maximum emission peaks in the red part of the spectrum offer convenient stem effect removal. This article outlines the main advantages and disadvantages of utilizing IOSs for SFD fabrication. IOSFDs with different configurations are presented, and their use for dosimetry in X-ray RT, brachytherapy (BT), proton therapy (PT), and boron neutron capture therapy (BNCT) is reviewed. Challenges including the percentage depth dose (PDD) deviation from the standard ion chamber (IC) measurement, the angular dependence, and the Cherenkov effect are discussed in detail; methods to overcome these problems are also presented.

OC-0110 Characterisation of an inorganic scintillation detector system for time resolved in vivo dosimetry

2021 ◽  
Vol 158 ◽  
pp. S77-S79
Author(s):  
J. Johansen ◽  
E.B. Johansen ◽  
J. Overgaard ◽  
D. Piché-Meunier ◽  
H.M.L. Rosales ◽  
...  
Keyword(s):  
Scintillation Detector ◽  
Detector System ◽  
In Vivo Dosimetry ◽  
Time Resolved

Diode in Vivo Dosimetry for Patients Receiving External Beam Radiation Therapy

10.37206/88 ◽  
2005 ◽  
Author(s):  
Ellen Yorke ◽  
Rodica Alecu ◽  
Li Ding ◽  
Doracy Fontenla ◽  
Andre Kalend ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
External Beam Radiation Therapy ◽  
External Beam Radiation ◽  
In Vivo Dosimetry ◽  
External Beam ◽  
Beam Radiation

scholarly journals Real-time observation of tetrapyrrole binding to an engineered bacterial phytochrome

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yusaku Hontani ◽  
Mikhail Baloban ◽  
Francisco Velazquez Escobar ◽  
Swetta A. Jansen ◽  
Daria M. Shcherbakova ◽  
...  
Keyword(s):  
Real Time ◽  
Rational Design ◽  
Near Infrared ◽  
Fluorescent Proteins ◽  
Covalent Bond ◽  
Binding Pocket ◽  
Tissue Imaging ◽  
Covalent Attachment ◽  
Time Resolved

AbstractNear-infrared fluorescent proteins (NIR FPs) engineered from bacterial phytochromes are widely used for structural and functional deep-tissue imaging in vivo. To fluoresce, NIR FPs covalently bind a chromophore, such as biliverdin IXa tetrapyrrole. The efficiency of biliverdin binding directly affects the fluorescence properties, rendering understanding of its molecular mechanism of major importance. miRFP proteins constitute a family of bright monomeric NIR FPs that comprise a Per-ARNT-Sim (PAS) and cGMP-specific phosphodiesterases - Adenylyl cyclases - FhlA (GAF) domain. Here, we structurally analyze biliverdin binding to miRFPs in real time using time-resolved stimulated Raman spectroscopy and quantum mechanics/molecular mechanics (QM/MM) calculations. Biliverdin undergoes isomerization, localization to its binding pocket, and pyrrolenine nitrogen protonation in <1 min, followed by hydrogen bond rearrangement in ~2 min. The covalent attachment to a cysteine in the GAF domain was detected in 4.3 min and 19 min in miRFP670 and its C20A mutant, respectively. In miRFP670, a second C–S covalent bond formation to a cysteine in the PAS domain occurred in 14 min, providing a rigid tetrapyrrole structure with high brightness. Our findings provide insights for the rational design of NIR FPs and a novel method to assess cofactor binding to light-sensitive proteins.

The use of prompt γ-rays for in-vivo dosimetry at therapeutic proton and ion beams

2011 ◽  
Author(s):  
F. Fiedler ◽  
U. Dersch ◽  
C. Golnik ◽  
T. Kormoll ◽  
A. Muller ◽  
...  
Keyword(s):  
Ion Beams ◽  
In Vivo Dosimetry

scholarly journals Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 485
Author(s):  
Veronika Huntosova ◽  
Denis Horvath ◽  
Robert Seliga ◽  
Georges Wagnieres
Keyword(s):  
Oxidative Stress ◽  
Tissue Oxygenation ◽  
Intact Cell ◽  
Molecular Probes ◽  
Stress Factors ◽  
Time Resolved ◽  
Invasive Approach ◽  
Oxygen Detection

Detection of tissue and cell oxygenation is of high importance in fundamental biological and in many medical applications, particularly for monitoring dysfunction in the early stages of cancer. Measurements of the luminescence lifetimes of molecular probes offer a very promising and non-invasive approach to estimate tissue and cell oxygenation in vivo and in vitro. We optimized the evaluation of oxygen detection in vivo by [Ru(Phen)3]2+ in the chicken embryo chorioallantoic membrane model. Its luminescence lifetimes measured in the CAM were analyzed through hierarchical clustering. The detection of the tissue oxygenation at the oxidative stress conditions is still challenging. We applied simultaneous time-resolved recording of the mitochondrial probe MitoTrackerTM OrangeCMTMRos fluorescence and [Ru(Phen)3]2+ phosphorescence imaging in the intact cell without affecting the sensitivities of these molecular probes. [Ru(Phen)3]2+ was demonstrated to be suitable for in vitro detection of oxygen under various stress factors that mimic oxidative stress: other molecular sensors, H2O2, and curcumin-mediated photodynamic therapy in glioma cancer cells. Low phototoxicities of the molecular probes were finally observed. Our study offers a high potential for the application and generalization of tissue oxygenation as an innovative approach based on the similarities between interdependent biological influences. It is particularly suitable for therapeutic approaches targeting metabolic alterations as well as oxygen, glucose, or lipid deprivation.

scholarly journals In vivo dosimetry and seed localization in prostate brachytherapy with permanent implants

2004 ◽  
Vol 51 (6) ◽  
pp. 3013-3018 ◽  
Author(s):  
A.B. Rosenfeld ◽  
D.L. Cutajar ◽  
M.L.F. Lerch ◽  
G.J. Takacs ◽  
J. Brady ◽  
...  
Keyword(s):  
In Vivo Dosimetry ◽  
Prostate Brachytherapy ◽  
Permanent Implants ◽  
Seed Localization

scholarly journals Transient ICD malfunctions during oncologic radiotherapy: a multi-centre, randomized, in-vitro study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
E Di Girolamo ◽  
M Appignani ◽  
N Furia ◽  
M Marini ◽  
P De Filippo ◽  
...  
Keyword(s):  
Real Time ◽  
Treatment Plan ◽  
Low Energy ◽  
In Vivo Dosimetry ◽  
Implantable Cardioverter Defibrillators ◽  
Shock Delivery ◽  
Transient Electromagnetic ◽  
Direct Exposure

Abstract Background Direct exposure of implantable cardioverter-defibrillators (ICDs) during radiotherapy is still considered potentially harmful, or even unsafe, by manufacturers and current recommendations. The effects of photon beams on ICDs are unpredictable, depending on multiple factors, and malfunctions may present during exposure. Purpose To evaluate transient ICD malfunctions by direct exposure to doses up to 10 Gy during low-energy RT, forty-three contemporary wireless-enabled ICDs, with at least 4 months to elective replacement indicator (ERI) were evaluated in a real-time in-vitro session in three different centres. Methods All ICDs had baseline interrogation. Single chamber devices were programmed to the VVI/40 mode and dual or triple chamber devices were programmed to the DDD/40 mode. Rate response function and antitachycardia therapies were disabled, with the ventricular tachycardia (VT)/ventricular fibrillation (VF) detection windows still active. A centring computed tomography was performed to build the corresponding treatment plan and the ICDs were blinded randomized to receive either 2-, 5- or 10-Gy exposure by a low photon-energy linear accelerator (6MV) in a homemade water phantom (600 MU/min). The effective dose received by the ICDs was randomly assessed by an in-vivo dosimetry. During radiotherapy, the ICDs were observed in a real-time session using manufacturer specific programmer, and device function (pacing, sensing, programmed parameters, arrhythmia detections) was recorder by the video camera in the bunker throughout the entire photon exposure. All ICDs had an interrogation session immediately after exposure. Results During radiotherapy course, almost all ICDs (93%) recorded major or minor transient electromagnetic interferences. On detail, sixteen ICDs (37.2%) reported atrial and/or ventricular oversensing, with base-rate-pacing inhibition and VT/VF detection. Twenty-four ICDs (55.8%) recorded non clinically relevant noise, and no detections were observed. Only three ICDs (7%) reported neither transient malfunction nor minor noise, withstanding direct radiation exposure. At immediate post-exposure interrogation, the ICDs that recorded major real-time malfunctions had VT/VF detections stored in the device memory. In none of the ICDs spontaneous changes in parameter settings were reported. Malfunctions occurred regardless of either 2-, 5- or 10-Gy photon beam exposure. Conclusions Transient electromagnetic interferences were observed in most of the contemporary ICDs during radiotherapy course, regardless of photon dose. To avoid potentially life-threatening ICD malfunctions such as pacing inhibition or inappropriate shock delivery, magnet application on the pocket site or ICD reprogramming to the asynchronous mode are still suggested in ICD patients ongoing even low energy radiotherapy exposure. Funding Acknowledgement Type of funding source: None

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