Ankyrin‐repeat and SOCS box‐containing protein 9 (ASB9) regulates ovarian granulosa cells function and MAPK signaling

2021 ◽  
Author(s):  
Soma Nosratpour ◽  
Kalidou Ndiaye
Keyword(s):  
Granulosa Cells ◽  
Mapk Signaling ◽  
Ankyrin Repeat ◽  
Ovarian Granulosa Cells ◽  
Socs Box

scholarly journals Ankyrin‐repeat and SOCS‐box Protein 9 (ASB9) regulate Ovarian Granulosa Cells function and MAPK signaling

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Soma Nosrat Pour ◽  
Kalidou Ndiaye
Keyword(s):  
Granulosa Cells ◽  
Mapk Signaling ◽  
Ankyrin Repeat ◽  
Ovarian Granulosa Cells ◽  
Socs Box

scholarly journals Chromatin Accessibility and Transcriptomic Alterations in Murine Ovarian Granulosa Cells Upon Deoxynivalenol Exposure

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2818
Author(s):  
Hairui Fan ◽  
Zhanshi Ren ◽  
Chao Xu ◽  
Haifei Wang ◽  
Zhengchang Wu ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Sulfur Metabolism ◽  
Hormone Secretion ◽  
Underlying Mechanism ◽  
Regulatory Elements ◽  
Mapk Signaling ◽  
Chromatin Accessibility ◽  
Ovarian Granulosa Cells ◽  
Vitro Model

Deoxynivalenol (DON) is a common environmental toxin that is secreted by fusarium fungi that frequently contaminates feedstuff and food. While the detrimental effects of DON on human and animal reproductive systems have been well recognized, the underlying mechanism remains poorly understood. Ovarian granulosa cells (GCs), which surround oocytes, are crucial for regulating oocyte development, mainly through the secretion of hormones such as estrogen and progesterone. Using an in vitro model of murine GCs, we characterized the cytotoxic effects of DON and profiled genome-wide chromatin accessibility and transcriptomic alterations after DON exposure. Our results suggest that DON can induce decreased viability and growth, increased apoptosis rate, and disrupted hormone secretion. In total, 2533 differentially accessible loci and 2675 differentially expressed genes were identified that were associated with Hippo, Wnt, steroid biosynthesis, sulfur metabolism, and inflammation-related pathways. DON-induced genes usually have a concurrently increased occupancy of active histone modifications H3K4me3 and H3K27ac in their promoters. Integrative analyses identified 35 putative directly affected genes including Adrb2 and Fshr, which are key regulators of follicular growth, and revealed that regions with increased chromatin accessibility are enriched with the binding motifs for NR5A1 and NR5A2, which are important for GCs. Moreover, DON-induced inflammatory response is due to the activation of the NF-κB and MAPK signaling pathways. Overall, our results provide novel insights into the regulatory elements, genes, and key pathways underlying the response of ovarian GCs to DON cytotoxicity.

cDNA cloning reveals the potential of human ovarian granulosa cells to secrete collagenase inhibitor

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S138
Author(s):  
J. FREUDENSTEIN ◽  
J. MUCHA ◽  
G. RAPP ◽  
K. H. SHEIT
Keyword(s):  
Cdna Cloning ◽  
Granulosa Cells ◽  
Ovarian Granulosa Cells ◽  
Collagenase Inhibitor

scholarly journals Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 ◽  
Vol 264 (20) ◽  
pp. 11762-11767 ◽  
Author(s):  
M Liscovitch ◽  
A Amsterdam
Keyword(s):  
Phospholipase D ◽  
Granulosa Cells ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Ovarian Granulosa Cells

C-myc promotes miR-92a-2-5p transcription in rat ovarian granulosa cells after cadmium exposure

2021 ◽  
Vol 421 ◽  
pp. 115536
Author(s):  
Yi Sun ◽  
Chaowei Zong ◽  
Jin Liu ◽  
Lingfeng Zeng ◽  
Qingyu Li ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Cadmium Exposure ◽  
Ovarian Granulosa Cells

miR-130a-3p regulates steroid hormone synthesis in goat ovarian granulosa cells by targeting the PMEPA1 gene

2021 ◽  
Vol 165 ◽  
pp. 92-98
Author(s):  
Lu Zhu ◽  
Jing Jing ◽  
Shuaiqi Qin ◽  
Qi Zheng ◽  
Jiani Lu ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Steroid Hormone ◽  
Hormone Synthesis ◽  
Ovarian Granulosa Cells
Sign in / Sign up

Export Citation Format

Share Document