Effects of the apparent transverse relaxation time on cerebral blood flow measurements obtained by arterial spin labeling

2005 ◽  
Vol 53 (2) ◽  
pp. 425-433 ◽  
Author(s):  
K.S. St. Lawrence ◽  
J. Wang
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Relaxation Time ◽  
Arterial Spin Labeling ◽  
Transverse Relaxation Time ◽  
Spin Labeling ◽  
Transverse Relaxation ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Accuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers

2015 ◽  
Vol 36 (10) ◽  
pp. 1816-1821 ◽  
Author(s):  
K. Ambarki ◽  
A. Wåhlin ◽  
L. Zarrinkoob ◽  
R. Wirestam ◽  
J. Petr ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

Cerebral blood flow measurements in infants using look-locker arterial spin labeling

2014 ◽  
Vol 41 (6) ◽  
pp. 1591-1600 ◽  
Author(s):  
Marta Varela ◽  
Esben T. Petersen ◽  
Xavier Golay ◽  
Joseph V. Hajnal
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients

Stroke ◽  
2017 ◽  
Vol 48 (9) ◽  
pp. 2441-2449 ◽  
Author(s):  
Audrey P. Fan ◽  
Jia Guo ◽  
Mohammad M. Khalighi ◽  
Praveen K. Gulaka ◽  
Bin Shen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Unilateral fetal-type circle of Willis anatomy causes right–left asymmetry in cerebral blood flow with pseudo-continuous arterial spin labeling: A limitation of arterial spin labeling-based cerebral blood flow measurements?

2016 ◽  
Vol 36 (9) ◽  
pp. 1570-1578 ◽  
Author(s):  
Jurriaan JH Barkeij Wolf ◽  
Jessica C Foster-Dingley ◽  
Justine EF Moonen ◽  
Matthias JP van Osch ◽  
Anton JM de Craen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Circle Of Willis ◽  
Flow Measurements ◽  
Blood Flow Signal ◽  
Continuous Arterial Spin Labeling ◽  
Blood Flow Measurements

The accuracy of cerebral blood flow measurements using pseudo-continuous arterial spin labeling can be affected by vascular factors other than cerebral blood flow, such as flow velocity and arterial transit time. We aimed to elucidate the effects of common variations in vascular anatomy of the circle of Willis on pseudo-continuous arterial spin labeling signal. In addition, we investigated whether possible differences in pseudo-continuous arterial spin labeling signal could be mediated by differences in flow velocities. Two hundred and three elderly participants underwent magnetic resonance angiography of the circle of Willis and pseudo-continuous arterial spin labeling scans. Mean pseudo-continuous arterial spin labeling-cerebral blood flow signal was calculated for the gray matter of the main cerebral flow territories. Mean cerebellar gray matter pseudo-continuous arterial spin labeling-cerebral blood flow was significantly lower in subjects having a posterior fetal circle of Willis variant with an absent P1 segment. The posterior fetal circle of Willis variants also showed a significantly higher pseudo-continuous arterial spin labeling-cerebral blood flow signal in the ipsilateral flow territory of the posterior cerebral artery. Flow velocity in the basilar artery was significantly lower in these posterior fetal circle of Willis variants. This study indicates that pseudo-continuous arterial spin labeling measurements underestimate cerebral blood flow in the posterior flow territories and cerebellum of subjects with a highly prevalent variation in circle of Willis morphology. Additionally, our data suggest that this effect is mediated by concomitant differences in flow velocity between the supplying arteries.

scholarly journals Pseudo-asymmetry of cerebral blood flow in arterial spin labeling caused by unilateral fetal-type circle of Willis: Technical limitation or a way to better understanding physiological variations of cerebral perfusion and improving arterial spin labeling acquisition?

2016 ◽  
Vol 36 (9) ◽  
pp. 1641-1643 ◽  
Author(s):  
B Law-ye ◽  
B Geerts ◽  
D Galanaud ◽  
D Dormont ◽  
N Pyatigorskaya
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Circle Of Willis ◽  
Flow Measurements ◽  
Technical Limitation ◽  
Continuous Arterial Spin Labeling ◽  
Blood Flow Measurements ◽  
Physiological Variations

In the recently published article, “Unilateral fetal-type circle of Willis anatomy causes right-left asymmetry in cerebral blood flow with pseudo-continuous arterial spin labeling: A limitation of arterial spin labeling-based cerebral blood flow measurements?”, it was shown by the method of arterial spin labeling (ASL) that unilateral fetal-type circle of Willis could induce variation of blood flow in cerebellar and posterior cerebral artery territory. We believe that the reported observation, rather than being a limitation, gives several interesting cues for understanding the ASL sequence. In this commentary, we formulate some suggestions regarding the use of ASL in clinical practice, discuss the potential causes of the above-mentioned pseudo-asymmetry and consider future improvements of the ASL technique.

Simultaneous PET/MR imaging of the brain: feasibility of cerebral blood flow measurements with FAIR-TrueFISP arterial spin labeling MRI

2012 ◽  
Vol 53 (9) ◽  
pp. 1066-1072 ◽  
Author(s):  
Lars Stegger ◽  
Petros Martirosian ◽  
Nina Schwenzer ◽  
Sotirios Bisdas ◽  
Armin Kolb ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mr Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
The Brain

scholarly journals Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review

2016 ◽  
Vol 36 (5) ◽  
pp. 842-861 ◽  
Author(s):  
Audrey P Fan ◽  
Hesamoddin Jahanian ◽  
Samantha J Holdsworth ◽  
Greg Zaharchuk
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Emission Tomography ◽  
Flow Measurements ◽  
Arterial Blood ◽  
Positron Emission

Noninvasive imaging of cerebral blood flow provides critical information to understand normal brain physiology as well as to identify and manage patients with neurological disorders. To date, the reference standard for cerebral blood flow measurements is considered to be positron emission tomography using injection of the [15O]-water radiotracer. Although [15O]-water has been used to study brain perfusion under normal and pathological conditions, it is not widely used in clinical settings due to the need for an on-site cyclotron, the invasive nature of arterial blood sampling, and experimental complexity. As an alternative, arterial spin labeling is a promising magnetic resonance imaging technique that magnetically labels arterial blood as it flows into the brain to map cerebral blood flow. As arterial spin labeling becomes more widely adopted in research and clinical settings, efforts have sought to standardize the method and validate its cerebral blood flow values against positron emission tomography-based cerebral blood flow measurements. The purpose of this work is to critically review studies that performed both [15O]-water positron emission tomography and arterial spin labeling to measure brain perfusion, with the aim of better understanding the accuracy and reproducibility of arterial spin labeling relative to the positron emission tomography reference standard.

Mouse lumbar and cervical spinal cord blood flow measurements by arterial spin labeling: Sensitivity optimization and first application

2009 ◽  
Vol 62 (2) ◽  
pp. 430-439 ◽  
Author(s):  
Guillaume Duhamel ◽  
Virginie Callot ◽  
Patrick Decherchi ◽  
Yann Le Fur ◽  
Tanguy Marqueste ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Arterial Spin Labeling ◽  
Cervical Spinal Cord ◽  
Spin Labeling ◽  
Spinal Cord Blood Flow ◽  
Flow Measurements ◽  
Blood Flow Measurements
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