In vivo MR spectroscopic imaging of polyunsaturated fatty acids (PUFA) in healthy and cancerous breast tissues by selective multiple-quantum coherence transfer (Sel-MQC): A preliminary study

2007 ◽  
Vol 58 (6) ◽  
pp. 1079-1085 ◽  
Author(s):  
Qiuhong He ◽  
Pavel Shkarin ◽  
Regina J. Hooley ◽  
Donald R. Lannin ◽  
Jeffrey C. Weinreb ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Quantum Coherence ◽  
Multiple Quantum ◽  
Coherence Transfer ◽  
Preliminary Study ◽  
Breast Tissues ◽  
Multiple Quantum Coherence ◽  
Mr Spectroscopic Imaging

scholarly journals Dependence of in vivo glutamine synthetase activity on ammonia concentration in rat brain studied by 1H - 15N heteronuclear multiple-quantum coherence-transfer NMR

1995 ◽  
Vol 311 (2) ◽  
pp. 681-688 ◽  
Author(s):  
K Kanamori ◽  
B D Ross ◽  
E L Kuo
Keyword(s):  
Quantum Coherence ◽  
Ammonia Concentration ◽  
Multiple Quantum ◽  
Blood Ammonia ◽  
Coherence Transfer ◽  
Heteronuclear Multiple Quantum Coherence ◽  
Glutamine Synthesis ◽  
Gaba Synthesis ◽  
Multiple Quantum Coherence

The dependence of the in vivo rate of glutamine synthesis on the substrate ammonia concentration was studied in rat brain by 1H-15N heteronuclear multiple-quantum coherence-transfer NMR in combination with biochemical techniques. In vivo rates were measured at various steady-state blood and brain ammonia concentrations within the ranges 0.4-0.55 mumol/g and 0.86-0.98 mumol/g respectively, after low-rate intravenous 15NH4+ infusion (isotope chase). The rate of glutamine synthesis at steady state was determined from the change in brain [5-15N]glutamine levels during isotope chase, observed selectively through the amide proton by NMR, and 15N enrichments of brain glutamine and of blood and brain ammonia measured byN gas chromatography-MS. The in vivo rate (v) was 3.3-4.5 mumol/h per g of brain at blood ammonia concentrations (s) of 0.40-0.55 mumol/g. A linear increase of 1/v with 1/s permitted estimation of the in vivo glutamine synthetase (GS) activity at a physiological blood ammonia concentration to be 0.4-2.1 mumol/h per g. The observed ammonia-dependence strongly suggests that, under physiological conditions, in vivo GS activity is kinetically limited by sub-optimal in situ concentrations of ammonia as well as glutamate and ATP. Comparison of the observed in vivo GS activity with the reported in vivo rates of glutaminase and of gamma-aminobutyrate (GABA) synthesis suggests that, under mildly hyperammonaemic conditions, glutamine is synthesized at a sufficiently high rate to serve as a precursor of GABA, but glutaminase-catalysed hydrolysis of glutamine is too slow to be the sole provider of glutamate used for GABA synthesis.

scholarly journals Optimal Phased-Array Signal Combination For Polyunsaturated Fatty Acids Measurement In Breast Cancer Using Multiple Quantum Coherence MR Spectroscopy At 3T

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Vasiliki Mallikourti ◽  
Sai Man Cheung ◽  
Tanja Gagliardi ◽  
Yazan Masannat ◽  
Steven D. Heys ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mr Spectroscopy ◽  
Quantum Coherence ◽  
Phased Array ◽  
Multiple Quantum ◽  
Signal Combination ◽  
Multiple Quantum Coherence

Single-Scan in Vivo Lactate Editing with Complete Lipid and Water Suppression by Selective Multiple-Quantum-Coherence Transfer (Sel-MQC) with Application to Tumors

1995 ◽  
Vol 106 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Q.H. He ◽  
D.C. Shungu ◽  
P.C.M. Vanzijl ◽  
Z.M. Bhujwalla ◽  
J.D. Glickson
Keyword(s):  
Quantum Coherence ◽  
Water Suppression ◽  
Multiple Quantum ◽  
Coherence Transfer ◽  
Multiple Quantum Coherence

Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo

2004 ◽  
Vol 22 (10) ◽  
pp. 1407-1412 ◽  
Author(s):  
Kerry L. Shannon ◽  
Rosa T. Branca ◽  
Gigi Galiana ◽  
Silvia Cenzano ◽  
Louis-Serge Bouchard ◽  
...  
Keyword(s):  
Quantum Coherence ◽  
Multiple Quantum ◽  
Simultaneous Acquisition ◽  
Multiple Orders ◽  
Multiple Quantum Coherence

scholarly journals In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer

2004 ◽  
Vol 52 (4) ◽  
pp. 902-906 ◽  
Author(s):  
Manickam Muruganandham ◽  
Jason A. Koutcher ◽  
Giuseppe Pizzorno ◽  
Qiuhong He
Keyword(s):  
Quantum Coherence ◽  
Multiple Quantum ◽  
Relaxation Measurements ◽  
Multiple Quantum Coherence

Proton NMR Observation of the Antineoplastic Agent IproplatinIn Vivo by Selective Multiple Quantum Coherence Transfer (Sel-MQC)

1995 ◽  
Vol 33 (3) ◽  
pp. 414-416 ◽  
Author(s):  
Qiuhong He ◽  
Zaver M. Bhujwalla ◽  
Ross J. Maxwell ◽  
John R. Griffiths ◽  
Jerry D. Glickson
Keyword(s):  
Quantum Coherence ◽  
Antineoplastic Agent ◽  
Proton Nmr ◽  
Multiple Quantum ◽  
Coherence Transfer ◽  
Multiple Quantum Coherence
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