Quantifying the blood oxygenation level dependent effect in cerebral blood volume–weighted functional MRI at 9.4T

2007 ◽  
Vol 58 (3) ◽  
pp. 616-621 ◽  
Author(s):  
Hanbing Lu ◽  
Clara A. Scholl ◽  
Yantao Zuo ◽  
Elliot A. Stein ◽  
Yihong Yang
Keyword(s):  
Functional Mri ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Dependent Effect ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models

2016 ◽  
Vol 37 (6) ◽  
pp. 2270-2282 ◽  
Author(s):  
Ararat Chakhoyan ◽  
Aurélien Corroyer-Dulmont ◽  
Marine M Leblond ◽  
Aurélie Gérault ◽  
Jérôme Toutain ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Volume Blood

The alleviation of hypoxia in glioblastoma with carbogen to improve treatment has met with limited success. Our hypothesis is that the eventual benefits of carbogen depend on the capacity for vasodilation. We examined, with MRI, changes in fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in response to carbogen. The analyses were performed in two xenograft models of glioma (U87 and U251) recognized to have different vascular patterns. Carbogen increased fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in contralateral tissues. In the tumor core and peritumoral regions, changes were dependent on the capacity to vasodilate rather than on resting fractional cerebral blood volume. In the highly vascularised U87 tumor, carbogen induced a greater increase in fractional cerebral blood volume and blood oxygen saturation in comparison to the less vascularized U251 tumor. The blood oxygenation level dependent signal revealed a delayed response in U251 tumors relative to the contralateral tissue. Additionally, we highlight the considerable heterogeneity of fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent within U251 tumor in which multiple compartments co-exist (tumor core, rim and peritumoral regions). Finally, our study underlines the complexity of the flow/metabolism interactions in different models of glioblastoma. These irregularities should be taken into account in order to palliate intratumoral hypoxia in clinical trials.

Sex Differences in Blood-Oxygenation-Level-Dependent Functional MRI With Primary Visual Stimulation

1998 ◽  
Vol 155 (3) ◽  
pp. 434-436 ◽  
Author(s):  
Jonathan M. Levin ◽  
Marjorie H. Ross ◽  
Jack H. Mendelson ◽  
Nancy K. Mello ◽  
Bruce M. Cohen ◽  
...  
Keyword(s):  
Sex Differences ◽  
Functional Mri ◽  
Visual Stimulation ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal

2010 ◽  
Vol 107 (34) ◽  
pp. 15246-15251 ◽  
Author(s):  
P. Tian ◽  
I. C. Teng ◽  
L. D. May ◽  
R. Kurz ◽  
K. Lu ◽  
...  
Keyword(s):  
Functional Mri ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Simultaneous Blood Oxygenation Level-Dependent and Cerebral Blood Flow Functional Magnetic Resonance Imaging during Forepaw Stimulation in the Rat

1999 ◽  
Vol 19 (8) ◽  
pp. 871-879 ◽  
Author(s):  
Afonso C. Silva ◽  
Sang-Pil Lee ◽  
Guang Yang ◽  
Costantino Iadecola ◽  
Seong-Gi Kim
Keyword(s):  
Correlation Coefficient ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Single Shot ◽  
Bold Signal ◽  
Doppler Flowmetry ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Signal Changes

The blood oxygenation level-dependent (BOLD) contrast mechanism can be modeled as a complex interplay between CBF, cerebral blood volume (CBV), and CMRO2. Positive BOLD signal changes are presumably caused by CBF changes in excess of increases in CMRO2. Because this uncoupling between CBF and CMRO2 may not always be present, the magnitude of BOLD changes may not be a good index of CBF changes. In this study, the relation between BOLD and CBF was investigated further. Continuous arterial spin labeling was combined with a single-shot, multislice echo-planar imaging to enable simultaneous measurements of BOLD and CBF changes in a well-established model of functional brain activation, the electrical forepaw stimulation of a-chloralose-anesthetized rats. The paradigm consisted of two 18- to 30-second stimulation periods separated by a 1-minute resting interval. Stimulation parameters were optimized by laser Doppler flowmetry. For the same cross-correlation threshold, the BOLD and CBF active maps were centered within the size of one pixel (470 µm). However, the BOLD map was significantly larger than the CBF map. Measurements taken from 15 rats at 9.4 T using a 10-millisecond echo-time showed 3.7 ± 1.7% BOLD and 125.67 ± 81.7% CBF increases in the contralateral somatosensory cortex during the first stimulation, and 2.6 ± 1.2% BOLD and 79.3 ± 43.6% CBF increases during the second stimulation. The correlation coefficient between BOLD and CBF changes was 0.89. The overall temporal correlation coefficient between BOLD and CBF time-courses was 0.97. These results show that under the experimental conditions of the current study, the BOLD signal changes follow the changes in CBF.

scholarly journals Blood oxygenation level-dependent (BOLD) functional MRI of visual stimulation in the rat retina at 11.7 T

2010 ◽  
Vol 24 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Bryan H. De La Garza ◽  
Eric R. Muir ◽  
Guang Li ◽  
Yen-Yu I. Shih ◽  
Timothy Q. Duong
Keyword(s):  
Functional Mri ◽  
Visual Stimulation ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Rat Retina ◽  
Blood Oxygenation Level ◽  
Oxygenation Level

scholarly journals Multi-Regional Investigation of the Relationship between Functional MRI Blood Oxygenation Level Dependent (BOLD) Activation and GABA Concentration

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117531 ◽  
Author(s):  
Ashley D. Harris ◽  
Nicolaas A. J. Puts ◽  
Brian A. Anderson ◽  
Steven Yantis ◽  
James J. Pekar ◽  
...  
Keyword(s):  
Functional Mri ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Gaba Concentration ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
The Relationship

scholarly journals Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

2017 ◽  
Vol 24 (2) ◽  
pp. 82-89 ◽  
Author(s):  
Saïd Boujraf ◽  
Rachida Belaïch ◽  
Abdelkhalek Housni ◽  
Mustapha Maaroufi ◽  
Siham Tizniti ◽  
...  
Keyword(s):  
Functional Mri ◽  
Brain Plasticity ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Hemodialysis Session ◽  
Blood Oxygenation Level ◽  
Adrenal Deficiency ◽  
Oxygenation Level
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