Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian-shaped and off-resonant spin-lock radiofrequency pulses in intervertebral disks

2016 ◽  
Vol 78 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Anja Müller-Lutz ◽  
Tom Cronenberg ◽  
Christoph Schleich ◽  
Frithjof Wickrath ◽  
Moritz Zaiss ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Spin Lock ◽  
Intervertebral Disks

Visualization of Spatial Distribution of Spermatogenesis in Mouse Testes Using Creatine Chemical Exchange Saturation Transfer Imaging

2021 ◽  
Author(s):  
Yusuke Takahashi ◽  
Hidetaka Kioka ◽  
Shinichiro Fukuhara ◽  
Sohei Kuribayashi ◽  
Shigeyoshi Saito ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer

scholarly journals In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3‐O‐Methyl‐D‐glucose in a murine tumor model

2021 ◽  
Author(s):  
Annasofia Anemone ◽  
Martina Capozza ◽  
Francesca Arena ◽  
Sara Zullino ◽  
Paola Bardini ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Tumor Model ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Murine Tumor ◽  
Murine Tumor Model

scholarly journals Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 402
Author(s):  
Miriam Frenken ◽  
Sven Nebelung ◽  
Christoph Schleich ◽  
Anja Müller-Lutz ◽  
Karl Ludger Radke ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Chemical Exchange ◽  
Clinical Pathology ◽  
Chemical Exchange Saturation Transfer ◽  
Low Back ◽  
Intervertebral Disks ◽  
Asymptomatic Volunteers

Using glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) magnetic resonance imaging (MRI), this study comparatively evaluated the GAG contents of lumbar intervertebral disks (IVDs) of patients with non-specific low back pain (nsLBP), radiculopathy, and asymptomatic volunteers to elucidate the association of clinical manifestation and compositional correlate. A total of 18 patients (mean age 57.5 ± 22.5 years) with radiculopathy, 16 age-matched patients with chronic nsLBP and 20 age-matched volunteers underwent standard morphologic and compositional gagCEST MRI on a 3T scanner. In all cohorts, GAG contents of lumbar IVDs were determined using gagCEST MRI. An assessment of morphologic IVD degeneration based on the Pfirrmann classification and T2-weighted sequences served as a reference. A linear mixed model adjusted for multiple confounders was used for statistical evaluation. IVDs of patients with nsLBP showed lower gagCEST values than those of volunteers (nsLBP: 1.3% [99% confidence intervals (CI): 1.0; 1.6] vs. volunteers: 1.9% [99% CI: 1.6; 2.2]). Yet, IVDs of patients with radiculopathy (1.8% [99% CI: 1.4; 2.1]) were not different from patients with nsLBP or volunteers. In patients with radiculopathy, IVDs directly adjacent to IVD extrusions demonstrated lower gagCEST values than distant IVDs (adjacent: 0.9% [99% CI: 0.3; 1.5], distant: 2.1% [99% CI: 1.7; 2.5]). Advanced GAG depletion in nsLBP and directly adjacent to IVD extrusions in radiculopathy indicates close interrelatedness of clinical pathology and compositional degeneration.

scholarly journals A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol

2017 ◽  
Vol 79 (3) ◽  
pp. 1553-1558 ◽  
Author(s):  
Yin Wu ◽  
Iris Y. Zhou ◽  
Takahiro Igarashi ◽  
Dario L. Longo ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri
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