scholarly journals Direct saturation-corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts

2017 ◽  
Vol 78 (6) ◽  
pp. 2307-2314 ◽  
Author(s):  
Iris Yuwen Zhou ◽  
Enfeng Wang ◽  
Jerry S. Cheung ◽  
Dongshuang Lu ◽  
Yang Ji ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Nuclear Overhauser Effect ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Amide Proton Transfer ◽  
Overhauser Effect ◽  
Nuclear Overhauser

scholarly journals MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T

2012 ◽  
Vol 69 (3) ◽  
pp. 760-770 ◽  
Author(s):  
Tao Jin ◽  
Ping Wang ◽  
Xiaopeng Zong ◽  
Seong-Gi Kim
Keyword(s):  
Mr Imaging ◽  
Proton Transfer ◽  
Nuclear Overhauser Effect ◽  
Transfer Effect ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Overhauser Effect ◽  
Nuclear Overhauser

scholarly journals Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI

2013 ◽  
Vol 27 (2) ◽  
pp. 163-174 ◽  
Author(s):  
Anna Tietze ◽  
Jakob Blicher ◽  
Irene Klaerke Mikkelsen ◽  
Leif Østergaard ◽  
Megan K. Strother ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Ischemic Penumbra ◽  
Saturation Transfer ◽  
Hyperacute Stroke ◽  
Amide Proton Transfer ◽  
Cest Mri

scholarly journals A fast and novel method for amide proton transfer‐chemical exchange saturation transfer multislice imaging

2021 ◽  
Author(s):  
Jan‐Rüdiger Schüre ◽  
Ulrich Pilatus ◽  
Ralf Deichmann ◽  
Elke Hattingen ◽  
Manoj Shrestha
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Amide Proton Transfer ◽  
Novel Method ◽  
Multislice Imaging

Effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study

2015 ◽  
Vol 9 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Tatsuhiro Wada ◽  
Osamu Togao ◽  
Chiaki Tokunaga ◽  
Ryouhei Funatsu ◽  
Kouji Kobayashi ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Proton Transfer ◽  
Pulse Duration ◽  
Chemical Exchange ◽  
Phantom Study ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Saturation Pulse ◽  
Amide Proton Transfer

scholarly journals Optimization of 7-T Chemical Exchange Saturation Transfer Parameters for Validation of Glycosaminoglycan and Amide Proton Transfer of Fibroglandular Breast Tissue

Radiology ◽  
2015 ◽  
Vol 275 (1) ◽  
pp. 255-261 ◽  
Author(s):  
Adrienne N. Dula ◽  
Blake E. Dewey ◽  
Lori R. Arlinghaus ◽  
Jason M. Williams ◽  
Dennis Klomp ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Breast Tissue ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Amide Proton Transfer ◽  
Transfer Parameters

Amide proton transfer imaging for differentiation of tuberculomas from high-grade gliomas: Preliminary experience

2021 ◽  
pp. 197140092110027
Author(s):  
Karthik Kulanthaivelu ◽  
Shumyla Jabeen ◽  
Jitender Saini ◽  
Sanita Raju ◽  
Atchayaram Nalini ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Spin Echo ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
High Grade ◽  
Saturation Pulse ◽  
Amide Proton Transfer ◽  
High Grade Gliomas ◽  
Amide Protons

Purpose Tuberculomas can occasionally masquerade as high-grade gliomas (HGG). Evidence from magnetisation transfer (MT) imaging suggests that there is lower protein content in the tuberculoma microenvironment. Building on the principles of chemical exchange saturation transfer and MT, amide proton transfer (APT) imaging generates tissue contrast as a function of the mobile amide protons in tissue’s native peptides and intracellular proteins. This study aimed to further the understanding of tuberculomas using APT and to compare it with HGG. Method Twenty-two patients ( n = 8 tuberculoma; n = 14 HGG) were included in the study. APT was a 3D turbo spin-echo Dixon sequence with inbuilt B0 correction. A two-second, 2 μT saturation pulse alternating over transmit channels was applied at ±3.5 ppm around water resonance. The APT-weighted image (APTw) was computed as the MT ratio asymmetry (MTRasym) at 3.5 ppm. Mean MTRasym values in regions of interest (areas = 9 mm2; positioned in component with homogeneous enhancement/least apparent diffusion coefficient) were used for the analysis. Results MTRasym values of tuberculomas ( n = 14; 8 cases) ranged from 1.34% to 3.11% ( M = 2.32 ± 0.50). HGG ( n = 17;14 cases) showed MTRasym ranging from 2.40% to 5.70% ( M = 4.32 ± 0.84). The inter-group difference in MTRasym was statistically significant ( p < 0.001). APTw images in tuberculomas were notable for high MTRasym values in the perilesional oedematous-appearing parenchyma (compared to contralateral white matter; p < 0.001). Conclusion Tuberculomas demonstrate lower MTRasym ratios compared to HGG, reflective of a relative paucity of mobile amide protons in the ambient microenvironment. Elevated MTRasym values in perilesional parenchyma in tuberculomas are a unique observation that may be a clue to the inflammatory milieu.

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