Evaluation of a similarity anisotropic diffusion denoising approach for improving in vivo CEST‐MRI tumor pH imaging

2021 ◽  
Vol 85 (6) ◽  
pp. 3479-3496
Author(s):  
Feriel Romdhane ◽  
Daisy Villano ◽  
Pietro Irrera ◽  
Lorena Consolino ◽  
Dario Livio Longo
Keyword(s):  
Anisotropic Diffusion ◽  
Tumor Ph ◽  
Ph Imaging ◽  
Cest Mri

scholarly journals Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI

2021 ◽  
pp. 667-688
Author(s):  
Hahnsung Kim ◽  
Yin Wu ◽  
Daisy Villano ◽  
Dario Livio Longo ◽  
Michael T. McMahon ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Kidney Injury ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Ph Imaging ◽  
Iodinated Contrast ◽  
Cest Mri ◽  
Renal Mri ◽  
Analysis Protocol

AbstractThe kidney plays a major role in maintaining body pH homeostasis. Renal pH, in particular, changes immediately following injuries such as intoxication and ischemia, making pH an early biomarker for kidney injury before the symptom onset and complementary to well-established laboratory tests. Because of this, it is imperative to develop minimally invasive renal pH imaging exams and test pH as a new diagnostic biomarker in animal models of kidney injury before clinical translation. Briefly, iodinated contrast agents approved by the US Food and Drug Administration (FDA) for computed tomography (CT) have demonstrated promise as novel chemical exchange saturation transfer (CEST) MRI agents for pH-sensitive imaging. The generalized ratiometric iopamidol CEST MRI analysis enables concentration-independent pH measurement, which simplifies in vivo renal pH mapping. This chapter describes quantitative CEST MRI analysis for preclinical renal pH mapping, and their application in rodents, including normal conditions and acute kidney injury.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concepts and experimental procedure.

A pH-responsive photoacoustic imaging probe for tumor pH imaging in vivo based on polyaniline–bovine serum albumin

2021 ◽  
Vol 33 ◽  
pp. 102356
Author(s):  
Ziyi Yang ◽  
Bingxin Gu ◽  
Chunjuan Jiang ◽  
Le Zhang ◽  
Qiufang Liu ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Photoacoustic Imaging ◽  
Ph Responsive ◽  
Imaging Probe ◽  
Tumor Ph ◽  
Ph Imaging

scholarly journals In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

2017 ◽  
Vol 51 (2) ◽  
pp. 498-506 ◽  
Author(s):  
Annasofia Anemone ◽  
Lorena Consolino ◽  
Laura Conti ◽  
Francesca Reineri ◽  
Federica Cavallo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Metabolic Response ◽  
In Vivo Evaluation ◽  
Ph Imaging ◽  
Early Metabolic Response

scholarly journals Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent

2017 ◽  
Vol 23 (8) ◽  
pp. 1752-1756 ◽  
Author(s):  
Lei Zhang ◽  
André F. Martins ◽  
Yuyan Mai ◽  
Piyu Zhao ◽  
Alexander M. Funk ◽  
...  
Keyword(s):  
Shift Reagent ◽  
Paramagnetic Shift ◽  
Cest Mri ◽  
Extracellular Lactate

scholarly journals Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

2019 ◽  
Vol 38 (1-2) ◽  
pp. 25-49 ◽  
Author(s):  
Annasofia Anemone ◽  
Lorena Consolino ◽  
Francesca Arena ◽  
Martina Capozza ◽  
Dario Livio Longo
Keyword(s):  
Tumor Acidosis ◽  
Tumor Ph

scholarly journals In vivo Measurement of Regional Brain and Tumor pH Using [14C]Dimethyloxazolidinedione and Quantitative Autoradiography

1985 ◽  
Vol 5 (3) ◽  
pp. 369-375 ◽  
Author(s):  
James B. Arnold ◽  
Larry Junck ◽  
David A. Rottenberg
Keyword(s):  
Water Content ◽  
Gray Matter ◽  
Quantitative Autoradiography ◽  
Water Volume ◽  
Consistent Difference ◽  
Extracellular Water ◽  
Tissue Water ◽  
Constant Weight ◽  
Tumor Ph

Using [14C]dimethyloxazolidinedione ([14C]-DMO) and quantitative autoradiography, we estimated tissue pH (pHt) and intracellular pH (pHi) in nine regions of the normal rat brain and in intracerebrally implanted RG-2 gliomas. Calculations of regional pHt, based on equilibrium tissue and arterial plasma [14C]DMO concentration, ranged from 6.83 to 6.94; pHi, calculated assuming an extracellular water volume of 0.15 ml/g for gray matter and 0.11 ml/g for white matter, ranged from 6.61 to 6.78. No consistent difference was found in pH, or pHi between white and gray matter regions. Tumor tissue water content was determined by drying to constant weight, and extracellular space water volume ( Ve) was estimated with [14C]sucrose in nephrectomized rats using quantitative autoradiography. Tumor pHt ranged from 7.08 to 7.18. For Ve = 0.17 (measured), pHi was 6.94–7.06; for Ve = 0.30 (assumed), the corresponding range for pHi was 6.63–6.90. Thus, the RG-2 glioma is not more “acidic” than adjacent brain tissue and its “alkaline” pHt probably reflects a large extracellular water content and plasma-like extracellular pH.

scholarly journals In Vivo Imaging of Composite Hydrogel Scaffold Degradation Using CEST MRI and Two‐Color NIR Imaging

2019 ◽  
Vol 29 (36) ◽  
pp. 1903753 ◽  
Author(s):  
Wei Zhu ◽  
Chengyan Chu ◽  
Shreyas Kuddannaya ◽  
Yue Yuan ◽  
Piotr Walczak ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Composite Hydrogel ◽  
Hydrogel Scaffold ◽  
Nir Imaging ◽  
Cest Mri ◽  
Scaffold Degradation

Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo.

Radiology ◽  
1990 ◽  
Vol 177 (2) ◽  
pp. 401-405 ◽  
Author(s):  
T L Chenevert ◽  
J A Brunberg ◽  
J G Pipe
Keyword(s):  
White Matter ◽  
Anisotropic Diffusion

scholarly journals 166: In Vivo Measurement of Cest MRI Signal in Murine Xenografts

2016 ◽  
Vol 120 ◽  
pp. S61
Author(s):  
Jonathan Klein ◽  
Gregory Czarnota ◽  
Wilfred Lam ◽  
Christine Tarapacki ◽  
Gregory Stanisz
Keyword(s):  
In Vivo Measurement ◽  
Cest Mri

Real time 3D in vivo pH imaging of stratum corneum revealed complex morphology-based regulation in mice

2017 ◽  
Vol 86 (2) ◽  
pp. e40 ◽  
Author(s):  
Yuki Furuichi ◽  
Takeshi Matsui ◽  
Masayuki Amagai
Keyword(s):  
Stratum Corneum ◽  
Real Time ◽  
Complex Morphology ◽  
Ph Imaging
Sign in / Sign up

Export Citation Format

Share Document