Long-term recovery In critical illness myopathy is complete, contrary to polyneuropathy

2014 ◽  
Vol 50 (3) ◽  
pp. 431-436 ◽  
Author(s):  
Susanne Koch ◽  
Tobias Wollersheim ◽  
Jeffrey Bierbrauer ◽  
Kurt Haas ◽  
Rudolf Mörgeli ◽  
...  
Keyword(s):  
Critical Illness ◽  
Critical Illness Myopathy

Long-term recovery in critical illness myopathy is complete, contrary to polyneuropathy

2014 ◽  
Vol 51 (4) ◽  
pp. 624-625
Author(s):  
Petra Baum ◽  
Joseph Classen
Keyword(s):  
Critical Illness ◽  
Critical Illness Myopathy

scholarly journals Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study

2008 ◽  
Vol 79 (7) ◽  
pp. 838-841 ◽  
Author(s):  
B Guarneri ◽  
G Bertolini ◽  
N Latronico
Keyword(s):  
Critical Illness ◽  
Critical Illness Myopathy ◽  
Term Outcome ◽  
Long Term Outcome

Critical Illness Myopathy, Steroids, and Cytochrome P450

1998 ◽  
Vol 55 (12) ◽  
pp. 1591-a-1591 ◽  
Author(s):  
J. E. Riggs
Keyword(s):  
Cytochrome P450 ◽  
Critical Illness ◽  
Critical Illness Myopathy

scholarly journals Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

2019 ◽  
Vol 316 (5) ◽  
pp. R584-R593 ◽  
Author(s):  
Sebastien Preau ◽  
Michael Ambler ◽  
Anna Sigurta ◽  
Anna Kleyman ◽  
Alex Dyson ◽  
...  
Keyword(s):  
Critical Illness ◽  
Functional Disability ◽  
Ex Vivo ◽  
Therapeutic Option ◽  
Limb Muscle ◽  
Fungal Cell ◽  
Hindlimb Muscles ◽  
Initial Reduction ◽  
Male Wistar Rats

An impaired capacity of muscle to regenerate after critical illness results in long-term functional disability. We previously described in a long-term rat peritonitis model that gastrocnemius displays near-normal histology whereas soleus demonstrates a necrotizing phenotype. We thus investigated the link between the necrotizing phenotype of critical illness myopathy and proteasome activity in these two limb muscles. We studied male Wistar rats that underwent an intraperitoneal injection of the fungal cell wall constituent zymosan or n-saline as a sham-treated control. Rats ( n = 74) were killed at 2, 7, and 14 days postintervention with gastrocnemius and soleus muscle removed and studied ex vivo. Zymosan-treated animals displayed an initial reduction of body weight but a persistent decrease in mass of both lower hindlimb muscles. Zymosan increased chymotrypsin- and trypsin-like proteasome activities in gastrocnemius at days 2 and 7 but in soleus at day 2 only. Activated caspases-3 and -9, polyubiquitin proteins, and 14-kDa fragments of myofibrillar actin (proteasome substrates) remained persistently increased from day 2 to day 14 in soleus but not in gastrocnemius. These results suggest that a relative proteasome deficiency in soleus is associated with a necrotizing phenotype during long-term critical illness. Rescuing proteasome clearance may offer a potential therapeutic option to prevent long-term functional disability in critically ill patients.

Acute and Severe Trabecular Bone Loss in a Rat Model of Critical Illness Myopathy

2021 ◽  
Author(s):  
Zbigniew Gugala ◽  
Nicola Cacciani ◽  
Gordon L. Klein ◽  
Lars Larsson
Keyword(s):  
Critical Illness ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Rat Model ◽  
Critical Illness Myopathy ◽  
Trabecular Bone Loss

scholarly journals The long-term metabolic outcomes of dysglycemia during critical illness

Critical Care ◽  
2010 ◽  
Vol 14 (6) ◽  
pp. 452
Author(s):  
Lavi Oud
Keyword(s):  
Critical Illness ◽  
Metabolic Outcomes
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