Reliability and validity of King's Health Questionnaire in patients with symptoms of overactive bladder with urge incontinence in Japan

2004 ◽  
Vol 23 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Shinichi Uemura ◽  
Yukio Homma
2017 ◽  
Vol 7 (12) ◽  
pp. 901
Author(s):  
Tsuyoshi Takara ◽  
Kazuo Yamamoto ◽  
Naoko Suzuki ◽  
Hiroshi Shimoda

Background: The seaberry is a yellow berry cultivated in China, Northern Europe, and West Asian countries. Numerous biological activities of seaberries have been reported, and we recently found that ursolic acid and a flavonoid in seaberry extract (SBE) suppressed the contraction of bladder muscle specimens and collagen gel containing bladder smooth muscle cells. However, the influence of SBE on urinary problems of Japanese adults has not been investigated. Therefore, we conducted a clinical trial of SBE supplementation in Japanese subjects with mild urinary dysfunction.Methods: We examined the effect of SBE (200 or 400 mg daily) containing ursolic acid (0.18 or 0.36 mg) in a randomized double-blind placebo-controlled study. Capsules containing SBE or placebo were administered for 8 weeks to Japanese men and women with mild urinary dysfunction. After 4 and 8 weeks of treatment, urinary symptoms were evaluated by using the King’s Health Questionnaire (KHQ) and the overactive bladder syndrome score (OABSS).Results: There was significant improvement of the KHQ emotion domain score after intake of 400 mg/day of SBE for 8 weeks compared with placebo. The answers to “Does your bladder problem make you depressed?” and “Does your bladder problem make you feel bad about yourself?” were significantly improved by SBE (400 mg/day) at 8 weeks. In the OABSS, the item “How often do you have a sudden desire to urinate, which is difficult to defer?” was significantly improved by SBE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects SBE. Conclusions: Intake of SBE (400 mg/day for 8 weeks) improved several emotional parameters related to urinary dysfunction. SBE may be useful for reducing moderate urinary symptoms.Keywords: King’s health questionnaire; overactive bladder syndrome score; seaberry; ursolic acid; overactive bladder; urination; micturition 


2010 ◽  
Vol 21 (4) ◽  
pp. 180-184 ◽  
Author(s):  
Eric Chieh-Lung Chou ◽  
Yao-Chi Chuang ◽  
Eric Chung-Cheng Wang ◽  
Hann-Chorng Kuo

2012 ◽  
Vol 153 (27) ◽  
pp. 1068-1076 ◽  
Author(s):  
Márta Péntek ◽  
László Gulácsi ◽  
Attila Majoros ◽  
Csaba Piróth ◽  
Levente Rubliczky ◽  
...  

The objektive of the research was to assess the health related quality of life and productivity of women with overactive bladder. Methods: A cross-sectional survey was performed in 5 outpatient centers. General health status (EQ-5D), disease-specific quality of life (King’s Health Questionnaire) and productivity (Work Productivity and Activity Impairment) were assessed. Results: Sixty-one women with mean age of 57.7 (SD = 11.6) years have had symptoms for 6.6 (SD = 6.2) years and 57 (93%) had incontinence. The EQ-5D (mean 0.668, SD = 0.314) was not significantly lower than that of the average population (p>0.05). The impact of incontinence and physical limitation (mean 70.5 and 68.9, respectively) were significant, the King’s Health Questionnaire-utility was 0.932 (SD = 0.029). Productivity scores of involved patients were: absenteeism 0.04% (SD = 0.11), presenteeism 43.64% (SD = 28.54), overall work impairment 40.97% (SD = 26.91), and other activities 47.72% (SD = 27.24). Conclusions: Applicability of the EQ-5D and King’s Health Questionnaire as utility measures in overactive bladder deserve further research. Presenteeism should be considered in the evaluation of the therapy. Orv. Hetil., 2012, 153, 1068–1076.


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