scholarly journals Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

2016 ◽  
Vol 29 (8) ◽  
pp. 1098-1107 ◽  
Author(s):  
Maria Dung Cao ◽  
Menglin Cheng ◽  
Asif Rizwan ◽  
Lu Jiang ◽  
Balaji Krishnamachary ◽  
...  

2018 ◽  
Vol Volume 11 ◽  
pp. 3195-3203 ◽  
Author(s):  
Shudong Gu ◽  
Haibin Liang ◽  
Donghui Qi ◽  
Liyan Mao ◽  
Guoxin Mao ◽  
...  


Neoplasma ◽  
2019 ◽  
Vol 66 (01) ◽  
pp. 54-62 ◽  
Author(s):  
Y. Z. Mi ◽  
F. Liu ◽  
X. L. Liang ◽  
S. N. Liu ◽  
X. C. Huang ◽  
...  






2007 ◽  
Vol 5 (10) ◽  
pp. 1031-1039 ◽  
Author(s):  
Chunjie Wang ◽  
Roya Navab ◽  
Vladimir Iakovlev ◽  
Yan Leng ◽  
Jinyi Zhang ◽  
...  


Author(s):  
Adilijiang Maimaitiming ◽  
Ailijiang Wusiman ◽  
Abulajiang Aimudula ◽  
Xuekelaiti Kuerban ◽  
Pengcheng Su

The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target gene of miR-152 in breast cancer. In addition, downexpression of ROCK1 could inhibit breast cancer cell proliferation, migration, and invasion. These findings indicate that miR-152 inhibited breast cancer growth and metastasis through negative regulation of ROCK1 expression. These data suggest that miR-152/ROCK1 pathway may be a useful therapeutic target for breast cancer treatment.



2016 ◽  
Vol 48 (5) ◽  
pp. 1933-1942 ◽  
Author(s):  
XINRAN LI ◽  
RUIJING XIAO ◽  
KINGSLEY TEMBO ◽  
LING HAO ◽  
MENG XIONG ◽  
...  


2017 ◽  
Vol 37 (5) ◽  
pp. 2672-2678 ◽  
Author(s):  
Jiangtu He ◽  
Jieying Mai ◽  
Yan Li ◽  
Linyi Chen ◽  
Hui Xu ◽  
...  


2019 ◽  
Vol 9 ◽  
Author(s):  
Jie Zhang ◽  
Mingfang Sun ◽  
Miaomiao Hao ◽  
Kexin Diao ◽  
Jian Wang ◽  
...  


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