Examining Activity Patterns and Biological Confounding Factors: Differences between Fibrocartilaginous and Fibrous Musculoskeletal Stress Markers

2012 ◽  
Vol 25 (3) ◽  
pp. 281-288 ◽  
Author(s):  
E. Weiss
Author(s):  
Elizabeth Weiss

This chapter focuses on locations called entheses where muscles attach to bones and whether muscle use can create changes at these locations. Entheseal changes, which have also been called musculoskeletal stress markers, have been utilized to reconstruct activity patterns in a wide range of studies. Some entheseal change researchers suggest that the muscle use causes microtrauma at the entheses; others suggest that bone remodeling (rather than repair) sufficiently explains the localized changes found at entheses. Yet entheseal changes also correlate with non-activity variables; age is the best predictor of entheseal changes. It seems that fibrocartilaginous entheses, which attach muscle to bone via a fibrous tendon, are less prone to non-activity confounds than the more often examined fibrous entheses, which involve large muscles that attach directly onto bone.


2009 ◽  
Vol 138 (4) ◽  
pp. 458-472 ◽  
Author(s):  
Angela R. Lieverse ◽  
Vladimir Ivanovich Bazaliiskii ◽  
Olga Ivanovna Goriunova ◽  
Andrzej W. Weber

2011 ◽  
Vol 28 ◽  
pp. 135-161 ◽  
Author(s):  
Ana Luísa Santos ◽  
Francisca Alves-Cardoso ◽  
Sandra Assis ◽  
Sébastien Villotte

2020 ◽  
Author(s):  
Ching-Chang Lee ◽  
Yi-Hsin Lin ◽  
Wen-Che Hou ◽  
Meng-Han Li ◽  
Jung-Wei Chang

Abstract Background: Concerns about the effects of nanoparticles (NPs) on human health are being raised by researchers because the risks of nanocosmetics like sunscreen are unknown. Methods: We explored the association between urinary oxidative stress markers and exposure of cosmetics salesclerks to 20 cosmetics which might contain titanium dioxide (TiO2)/zinc oxide (ZnO) NPs. We then recruited 40 cosmetics salesclerks and 24 clothing salesclerks and categorized them based on their exposure to ZnO and TiO2 NPs. Results: Nineteen and fifteen samples met the EU definition for TiO2 and ZnO nanomaterials, respectively. Participants with a higher co-exposure index of ZnO and TiO2 NPs had a significantly higher base level of urinary 8-hydroxy-2'-deoxyguanosin (8-OHdG) concentrations than the lower co-exposure group (5.82 vs. 2.85 ng/mL, p < 0.001). After potential confounding factors had been adjusted for, the TiO2 and ZnO NP co-exposure index was significantly positively associated with the urinary 8-OHdG base concentration (β = 0.308, 95% CI = 0.106 to 0.510) and the creatinine-adjusted concentration (β = 0.486, 95% CI = 0.017 to 0.954). Conclusion: Current evidence suggests that the likelihood of harm from using sunscreens containing nanoparticles might result in higher urinary 8-OHdG. However, our limited number and types of sample cosmetics might underestimate the risk.


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