scholarly journals Alternate day fasting combined with a low‐carbohydrate diet for weight loss, weight maintenance, and metabolic disease risk reduction

2019 ◽  
Vol 5 (6) ◽  
pp. 531-539 ◽  
Author(s):  
Faiza Kalam ◽  
Kelsey Gabel ◽  
Sofia Cienfuegos ◽  
Eric Wiseman ◽  
Mark Ezpeleta ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Weight Loss ◽  
Risk Reduction ◽  
Disease Risk ◽  
Weight Maintenance ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Metabolic Disease Risk ◽  
Low Carbohydrate ◽  
Alternate Day Fasting

scholarly journals Changes in Body Weight in Relation to Appetite During 6 Months of Alternate Day Fasting with a Low Carbohydrate Diet

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1646-1646
Author(s):  
Faiza Kalam ◽  
Kelsey Gabel ◽  
Sofia Cienfuegos ◽  
Mark Ezpeleta ◽  
Vasiliki Pavlou ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Weight Maintenance ◽  
Model Assessment ◽  
Maintenance Period ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Funding Sources ◽  
Low Carbohydrate ◽  
Alternate Day Fasting

Abstract Objectives Alternate day fasting (ADF) has been shown to lower body weight and improve subjective appetite by increasing fullness over time. What remains unknown, however, is whether carbohydrate restriction during ADF would provide additional weight loss benefits by helping to lower hunger as well. Accordingly, this study examined the effect of 6-months of ADF combined with a low carbohydrate diet on fasting and postprandial appetite ratings. The relationship between changes in appetite and body weight was also examined. Methods Adults with obesity (n = 31) participated in ADF (600 kcal “fast day” alternated with an ad libitum “feast day”) with a low-carbohydrate background diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3- month weight loss period followed by a 3-month weight maintenance period. Results Body weight (P < 0.001) decreased by 5.5 ± 0.5% by month 3 (end of weight loss period) and by 6.3 ± 1.0% by month 6 (end of weight maintenance period). Subjective hunger and fullness did not change during the weight loss period, or the weight maintenance period. Hunger and fullness were not related to changes in body weight during the weight loss or weight maintenance periods. Fasting insulin decreased (P = 0.03) by − 24 ± 8% by month 6 relative to baseline. Fasting glucose and homeostatic model assessment of insulin resistance (HOMA-IR), remained unchanged over the course of the study. Conclusions These findings suggest that ADF combined with a low carbohydrate diet is an effective way of lowering body weight. However, these weight loss benefits are not related to improvements in hunger or fullness. Funding Sources Nestle Health Sciences.

scholarly journals Alternate Day Fasting Combined with a Low Carbohydrate Diet: Effect on Sleep Quality, Duration, Insomnia Severity and Risk of Obstructive Sleep Apnea in Adults with Obesity

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 211
Author(s):  
Faiza Kalam ◽  
Kelsey Gabel ◽  
Sofia Cienfuegos ◽  
Mark Ezpeleta ◽  
Eric Wiseman ◽  
...  
Keyword(s):  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Weight Maintenance ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Obstructive Sleep ◽  
Low Carbohydrate ◽  
Insomnia Severity

Background: Alternate day fasting combined with a low carbohydrate diet (ADF-LC) is an effective weight loss regimen. Whether the weight loss induced by ADF-LC can improve sleep, remains unknown. Objective: This study examined the effect an ADF-LC diet on sleep quality, duration, insomnia severity and the risk of obstructive sleep apnea. Methods: Adults with obesity (n = 31) participated in ADF (600 kcal “fast day”; ad libitum intake “feast day”) with a low-carbohydrate diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight loss period followed by a 3-month weight maintenance period. Results: Reductions in body weight (−5 ± 1 kg, p < 0.001) and fat mass (−4 ± 1 kg, p < 0.01) were noted during the weight loss period, and these reductions were sustained during the weight maintenance period. Lean mass and visceral fat remained unchanged. The Pittsburgh Sleep Quality Index (PSQI) score indicated poor sleep quality at baseline (6.4 ± 0.7) with no change by month 3 or 6, versus baseline. ISI score indicated subthreshold insomnia at baseline (8.5 ± 1.0), with no change by month 3 or 6, versus baseline. The percent of subjects with high risk of obstructive sleep apnea at baseline was 45%, with no change by month 3 or 6. Wake time, bedtime, and sleep duration remained unchanged. Conclusion: The ADF-LC diet does not impact sleep quality, duration, insomnia severity or the risk of obstructive sleep apnea in adults with obesity.

scholarly journals Alternate Day Fasting Combined with a High Protein/low Carbohydrate Diet: Effect on Body Weight and Metabolic Disease Risk Factors in Obese Adults (P21-018-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Faiza Kalam ◽  
Kelsey Gabel ◽  
Eric Wiseman ◽  
Krista Varady
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Fat Mass ◽  
Disease Risk ◽  
High Protein ◽  
Obese Adults ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Alternate Day Fasting

Abstract Objectives This pilot study is the first to examine the impact of alternate day fasting (ADF) combined with a high protein/low carbohydrate diet on body weight and metabolic disease risk factors in obese adults. Methods Obese adults (n = 10) followed an ADF diet (600 kcal fast day alternated with an ad libitum feast day; 35% protein, 22% carbohydrate, 43% fat) for 6 months. Meal replacements were consumed on the fast and feast days, in addition to regular foods, to help attain macronutrient targets. Results Body weight decreased (P < 0.001) by 8.4 ± 1.7 kg (8.6 ± 1.7%) after 6 months. Fat mass and visceral fat mass were reduced (P < 0.05) by 6.4 ± 1.6 kg and 0.2 ± 0.1 kg, respectively. Lean mass decreased (P < 0.05) by 1.3 ± 0.6 kg. Systolic blood pressure was reduced (P < 0.05) by 10 ± 3 mm Hg, and diastolic blood pressure was reduced (P < 0.05) by 6 ± 3 mm Hg. Fasting glucose, insulin, insulin resistance, and HbA1c remained unchanged after 6 months of diet. LDL cholesterol and triglyceride levels decreased (P < 0.001) by10 ± 4% and 15 ± 8%, respectively, after 6 months. HDL cholesterol levels decreased by 6 ± 3% from baseline to post-treatment. Conclusions These preliminary findings suggest that ADF combined with a high protein/low carbohydrate diet is effective for lowering body weight, visceral fat mass, blood pressure, LDL cholesterol and triglyceride levels. However, this diet has no effect on glucoregulatory factors. While these preliminary findings are promising, they still require confirmation by a larger-scale clinical trial. Funding Sources Nestle Health Sciences Grant.

scholarly journals Beyond “Counting Macros”: Are Common Fad Diets Nutritionally Adequate? An Examination of Their Micronutrient Content

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1823-1823
Author(s):  
Neal Malik ◽  
Serena Tonstad ◽  
Ella Haddad
Keyword(s):  
Weight Loss ◽  
Disease Risk ◽  
Controlled Trial ◽  
Carbohydrate Diet ◽  
High Fiber ◽  
Low Carbohydrate Diet ◽  
Funding Sources ◽  
Low Carbohydrate ◽  
Calcium Magnesium

Abstract Objectives We compared a high-fiber bean-rich diet with a low-carbohydrate diet in a randomized controlled trial to assess their effects on body weight, blood lipids and micronutrient adequacy. Methods One hundred and seventy-three women and men with a mean body mass index of approximately 36 kg · m−2 were randomized to a high-fiber bean-rich diet that achieved mean (SD) fiber intakes of 35.5 (18.6) g · day−1 for women and 42.5 (30.3) g · day−1 for men, or a low-carbohydrate diet (&lt;120 g · day−1). Both diets were induced gradually over 4 weeks and included a 3-day feeding phase. Results After 52 weeks, the low-carbohydrate (n = 24) group tended to retain weight loss better than the high-fiber group (n = 30) (P = 0.06), although total cholesterol remained lower with the bean-rich diet (P = 0.049). The low-carbohydrate group consumed more vitamin K (P = 0.006), thiamin (P = 0.001), and niacin (P = 0.02) whereas those in the high-fiber group consumed more folate (P = 0.006), magnesium (P = 0.046) and copper (P = 0.017). Both groups consumed less than the RDA for vitamin D, vitamin E, calcium, magnesium and copper. Conclusions A high-fiber bean-rich diet was as effective as a low-carbohydrate diet for weight loss. However, both diets were deficient in micronutrients. These results may have implications for long-term disease risk and morbidity management. Funding Sources Lifestyle Center of America (Sulphur, OK).

scholarly journals Impact of Weight Regain on Metabolic Disease Risk: A Review of Human Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Cynthia M. Kroeger ◽  
Kristin K. Hoddy ◽  
Krista A. Varady
Keyword(s):  
Metabolic Disease ◽  
Weight Loss ◽  
Weight Regain ◽  
Plasma Lipids ◽  
Disease Risk ◽  
Weight Maintenance ◽  
Metabolic Disease Risk ◽  
Complete Reversal ◽  
Risk Parameters ◽  
The Impact

Dietary restriction interventions are effective for weight loss and reduction of chronic disease risk. Unfortunately, most people tend to regain much of this lost weight within one year after intervention. While some studies suggest that minor degrees of weight regain have no effect on metabolic disease risk parameters, other studies demonstrate a complete reversal in metabolic benefits. In light of these conflicting findings, it is of interest to determine how complete weight maintenance versus mild weight regain affects key risk parameters. These findings would have important clinical implications, as they could help identify a weight regain threshold that could preserve the metabolic benefits of weight loss. Accordingly, this review examined the impact of no weight regain versus mild regain on various metabolic disease risk parameters, including plasma lipids, blood pressure, glucose, and insulin concentrations, in adult subjects.

scholarly journals Alternate Day Fasting Combined With a Low Carbohydrate Diet: Effect on Sleep Quality, Duration, Insomnia Severity and Risk of Obstructive Sleep Apnea in Adults With Obesity

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1220-1220
Author(s):  
Faiza Kalam
Keyword(s):  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Weight Maintenance ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Obstructive Sleep ◽  
Low Carbohydrate ◽  
Insomnia Severity

Abstract Objectives Alternate day fasting combined with a low carbohydrate diet (ADF-LC) is an effective weight loss regimen. Whether the weight loss induced by ADF-LC can improve sleep remains unknown. This study examined an ADF-LC diet's effect on sleep quality, duration, insomnia severity, and the risk of obstructive sleep apnea. Methods Adults with obesity (n = 31) participated in ADF (600 kcal “fast day”; ad libitum intake “feast day”) with a low-carbohydrate diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight-loss period followed by a 3-month weight maintenance period. Results Reductions in body weight (−5 ± 1 kg, P &lt; 0.001) and fat mass (−4 ± 1 kg, P &lt; 0.01) were noted during the weight-loss period, and these reductions were sustained during the weight maintenance period. Lean mass and visceral fat remained unchanged. The Pittsburgh Sleep Quality Index (PSQI) score indicated poor sleep quality at baseline (6.4 ± 0.7) with no change by month 3 or 6, versus baseline. ISI score indicated subthreshold insomnia at baseline (8.5 ± 1.0), with no change by month 3 or 6, versus baseline. The % of subjects with a high risk of obstructive sleep apnea was 45% at baseline, with no change by month 3 or 6. Wake time, bedtime, and sleep duration remained unchanged. Conclusions The ADF-LC diet does not impact sleep quality, duration, insomnia severity, or the risk of obstructive sleep apnea in adults with obesity. Funding Sources Nestle Health Sciences.

scholarly journals Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

BMJ ◽  
2018 ◽  
pp. k4583 ◽  
Author(s):  
Cara B Ebbeling ◽  
Henry A Feldman ◽  
Gloria L Klein ◽  
Julia M W Wong ◽  
Lisa Bielak ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Total Energy ◽  
Total Energy Expenditure ◽  
Carbohydrate Diet ◽  
Intention To Treat ◽  
Low Carbohydrate Diet ◽  
High Carbohydrate ◽  
Low Carbohydrate ◽  
Treat Analysis

AbstractObjectiveTo determine the effects of diets varying in carbohydrate to fat ratio on total energy expenditure.DesignRandomized trial.SettingMulticenter collaboration at US two sites, August 2014 to May 2017.Participants164 adults aged 18-65 years with a body mass index of 25 or more.InterventionsAfter 12% (within 2%) weight loss on a run-in diet, participants were randomly assigned to one of three test diets according to carbohydrate content (high, 60%, n=54; moderate, 40%, n=53; or low, 20%, n=57) for 20 weeks. Test diets were controlled for protein and were energy adjusted to maintain weight loss within 2 kg. To test for effect modification predicted by the carbohydrate-insulin model, the sample was divided into thirds of pre-weight loss insulin secretion (insulin concentration 30 minutes after oral glucose).Main outcome measuresThe primary outcome was total energy expenditure, measured with doubly labeled water, by intention-to-treat analysis. Per protocol analysis included participants who maintained target weight loss, potentially providing a more precise effect estimate. Secondary outcomes were resting energy expenditure, measures of physical activity, and levels of the metabolic hormones leptin and ghrelin.ResultsTotal energy expenditure differed by diet in the intention-to-treat analysis (n=162, P=0.002), with a linear trend of 52 kcal/d (95% confidence interval 23 to 82) for every 10% decrease in the contribution of carbohydrate to total energy intake (1 kcal=4.18 kJ=0.00418 MJ). Change in total energy expenditure was 91 kcal/d (95% confidence interval −29 to 210) greater in participants assigned to the moderate carbohydrate diet and 209 kcal/d (91 to 326) greater in those assigned to the low carbohydrate diet compared with the high carbohydrate diet. In the per protocol analysis (n=120, P<0.001), the respective differences were 131 kcal/d (−6 to 267) and 278 kcal/d (144 to 411). Among participants in the highest third of pre-weight loss insulin secretion, the difference between the low and high carbohydrate diet was 308 kcal/d in the intention-to-treat analysis and 478 kcal/d in the per protocol analysis (P<0.004). Ghrelin was significantly lower in participants assigned to the low carbohydrate diet compared with those assigned to the high carbohydrate diet (both analyses). Leptin was also significantly lower in participants assigned to the low carbohydrate diet (per protocol).ConclusionsConsistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.Trial registrationClinicalTrials.govNCT02068885.

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