Behaviour of Anionic and Cationic Hydrogels

PAMM ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Karsten Keller ◽  
Thomas Wallmersperger ◽  
Tim Ricken
Keyword(s):  
Cationic Hydrogels

scholarly journals Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells

2002 ◽  
Vol 54 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Serguei V Vinogradov ◽  
Tatiana K Bronich ◽  
Alexander V Kabanov
Keyword(s):  
Drug Delivery ◽  
Cationic Hydrogels

In vitro integration of human skin dermis with porous cationic hydrogels

2009 ◽  
Vol 5 (9) ◽  
pp. 3337-3345 ◽  
Author(s):  
Antonio Peramo ◽  
Joong Hwan Bahng ◽  
Cynthia L. Marcelo ◽  
Nicholas Kotov ◽  
David C. Martin
Keyword(s):  
Human Skin ◽  
Cationic Hydrogels

scholarly journals Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides

2013 ◽  
Vol 9 ◽  
pp. 1652-1662 ◽  
Author(s):  
Christian Dollendorf ◽  
Martin Hetzer ◽  
Helmut Ritter
Keyword(s):  
Polymer Networks ◽  
Ammonium Salts ◽  
Reactive Orange 16 ◽  
Redox Responsive ◽  
Molecular Inclusion ◽  
Cloud Points ◽  
Responsive Behavior ◽  
Amine Groups ◽  
Reactive Orange ◽  
Cationic Hydrogels

A redox-responsive polycationic system was synthesized via copolymerization of N,N-diethylacrylamide (DEAAm) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). N,N’-bis(4-chlorobutanoyl)cystamine was used as disulfide-containing cross-linker to form networks by the quaternization of tertiary amine groups. The insoluble cationic hydrogels become soluble by reduction of disulfide to mercaptanes by use of dithiothreitol (DTT), tris(2-carboxyethyl)phosphine (TCEP) or cysteamine, respectively. The soluble polymeric system can be cross-linked again by using oxygen or hydrogen peroxide under basic conditions. The redox-responsive polymer networks can be used for molecular inclusion and controlled release. As an example, phenolphthalein, methylene blue and reactive orange 16 were included into the network. After treatment with DTT a release of the dye could be recognized. Physical properties of the cross-linked materials, e.g., glass transition temperature (T g), swelling behavior and cloud points (T c) were investigated. Redox-responsive behavior was further analyzed by rheological measurements.

Injectable cationic hydrogels with high antibacterial activity and low toxicity

2016 ◽  
Vol 7 (36) ◽  
pp. 5620-5624 ◽  
Author(s):  
Hong Du ◽  
Ying Wang ◽  
Xuxia Yao ◽  
Qiaojie Luo ◽  
Weipu Zhu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Physiological Conditions ◽  
High Antibacterial Activity ◽  
Low Toxicity ◽  
Cationic Hydrogels

We prepared injectable cationic hydrogels with strong antibacterial activity and remarkably low toxicity by in situ thiol–ene “click” reaction between dimethacrylate terminated poly(hexamethylene guanidine) (PHMGDMA) and poly[oligo(ethylene) glycol mercaptosuccinate] (POEGMS) under physiological conditions.

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