Synthesis and properties of Polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate-co-methoxy polyethylene glycol monomethacrylate) as non-viral gene vector

2010 ◽  
Vol 22 (12) ◽  
pp. 1925-1930 ◽  
Author(s):  
Shutao Guo ◽  
Yong Qiao ◽  
Weiwei Wang ◽  
Jinfeng Xing ◽  
Liandong Deng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Viral Gene ◽  
Gene Vector ◽  
Ethyl Methacrylate ◽  
Methoxy Polyethylene Glycol

Self-Assemble Behavior of Amphiphilic Diblock Copolymer of Methoxy Poly (Ethylene Glycol)/Polyester

2011 ◽  
Vol 295-297 ◽  
pp. 11-15
Author(s):  
Hao Zhou ◽  
Qing Hong Liang ◽  
Xiang Ke Shi ◽  
Li Hua Lu ◽  
Li Qun Zhang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Light Scattering ◽  
Diblock Copolymer ◽  
Diblock Copolymers ◽  
Average Diameter ◽  
Core Shell ◽  
Amphiphilic Diblock Copolymer ◽  
Amphiphilic Diblock Copolymers ◽  
Methoxy Polyethylene Glycol ◽  
Solution Polycondensation

Amphiphilic diblock copolymers based on methoxy polyethylene glycol (MePEG), 1, 6-hexanediol and maleic anhydride with different molar composition were synthesized by solution polycondensation. Self-assemble behavior of amphiphilic diblock copolymer in different solvents by dialyzing technique was discussed. The micelle morphologhy was observed by TEM. It was found that well core-shell MePEG1900/Polyester 2162 copolymer nanoparticles can be formed by self-assemble in acetone solution. In addition, the size of nanospheres measured using dynamic light scattering exhibited a narrow monodisphere size distribution and an average diameter in the ranger of less than 200nm.

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