scholarly journals Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma

2017 ◽  
Vol 243 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Claudio Luchini ◽  
Antonio Pea ◽  
Gemma Lionheart ◽  
Andrea Mafficini ◽  
Alessia Nottegar ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Ductal Adenocarcinoma

scholarly journals Undifferentiated carcinoma with osteoclastic giant cells of pancreas: Case report and brief literature review

2021 ◽  
Vol 6 (4) ◽  
pp. 307-310
Author(s):  
Jyoti Parag Dekate ◽  
Manjula V Kelkeri ◽  
Gowri Garudadri
Keyword(s):  
Literature Review ◽  
Giant Cells ◽  
Genetic Alterations ◽  
Undifferentiated Carcinoma ◽  
Survival Period ◽  
Prolonged Survival ◽  
Ductal Adenocarcinoma ◽  
Genetic Profile ◽  
Rare Neoplasm ◽  
Pathologic Features

Undifferentiated carcinoma with osteoclastic giant cells is a distinctive rare neoplasm involving pancreas and rarely bile ducts. This neoplasm shows characteristic histologic features with variable admixture of mononuclear histiocytic cells, non- neoplastic osteoclastic giant cells and neoplastic mononuclear cell component. Though, this tumor has been shown to share genetic alterations with pancreatic ductal adenocarcinoma, clinically, it behaves unpredictably with a substantial proportion of patient showing prolonged survival period. We present a case of this rare pancreatic tumour with brief literature review discussing the key pathologic features, immunophenotype, genetic profile and clinical behavior. Undifferentiated carcinoma with osteoclastic giant cells is a rare neoplasm in pancreas which is believed to be of epithelial origin and shares genetic aberrations with ductal adenocarcinoma. Despite this, these tumours have better prognosis with prolonged survival period.

scholarly journals Durable Response to PD-1 Blockade in a Patient With Metastatic Pancreatic Undifferentiated Carcinoma With Osteoclast-Like Giant Cells

2021 ◽  
Vol 19 (3) ◽  
pp. 247-252
Author(s):  
Robert J. Besaw ◽  
Adrienne R. Terra ◽  
Grace L. Malvar ◽  
Tobias R. Chapman ◽  
Lauren M. Hertan ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Next Generation ◽  
Durable Response ◽  
Tumor Mutation Burden ◽  
Mutation Burden ◽  
Generation Sequencing

Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a rare and potentially aggressive variant of pancreatic ductal adenocarcinoma. Data on this disease are sparse, and despite genetic similarities to pancreatic ductal adenocarcinoma, UCOGC clinical outcomes can be markedly different. We report on a female patient aged 62 years who presented with UCOGC with pulmonary metastases initially treated with 2 lines of cytotoxic chemotherapy. After rapid disease progression with both cytotoxic treatments, the patient’s tissue was sent for next-generation sequencing, which revealed a high tumor mutation burden (32 mutations per megabase), as well as somatic mutations in BRAF, NF1, PIK3CA, CDKN2A, TERT, and TP53. Pancreatic cancers have previously demonstrated suboptimal responses to immunotherapeutic approaches. However, given the high tumor mutation burden and distinctiveness of the tumor class, the patient began third-line pembrolizumab monotherapy after palliative radiation to the rapidly progressing and painful abdominal mass from her primary tumor. She had a marked response in her primary UCOGC tumor and metastatic sites, and she remains on pembrolizumab monotherapy with ongoing response after 32 months of therapy. Recent evidence showing significant PD-L1 enrichment on neoplastic cells of undifferentiated carcinomas (including UCOGC) may indicate a role for immunotherapeutic approaches in these patients. Rare cancers such as UCOGC and other undifferentiated carcinomas may benefit from next-generation sequencing to inform treatment decisions when standards of care are absent, as in this report.

Imaging features of undifferentiated carcinoma with osteoclastic giant cells of the pancreas

2020 ◽  
Vol 101 (12) ◽  
pp. 839-841
Author(s):  
R. Aldhaheri ◽  
M. Barat ◽  
A. Dohan ◽  
S. Gaujoux ◽  
R. Coriat ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Imaging Features

scholarly journals Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas in a Patient with New Diagnosis of Follicular Non-Hodgkinʼs Lymphoma

2014 ◽  
Vol 1 (2) ◽  
pp. 109-111 ◽  
Author(s):  
Apeksha Shah ◽  
Tanvi Khurana ◽  
Lauren Freid ◽  
Ali A. Siddiqui
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
New Diagnosis

scholarly journals Huge and recurrent undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

2018 ◽  
Vol 8 (4) ◽  
pp. 457-460 ◽  
Author(s):  
Lan Zhang ◽  
Jeong Min Lee ◽  
Jeong Hee Yoon ◽  
Ijin Joo ◽  
Hyo Jin Kang ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma

scholarly journals Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region

Cancer ◽  
1998 ◽  
Vol 83 (5) ◽  
pp. 1051-1051 ◽  
Author(s):  
Kim Deckard-Janatpour ◽  
Raymond L. Teplitz ◽  
Byung Hee Min ◽  
Boris H. Ruebner ◽  
Paul H. Gumerlock
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Periampullary Region

scholarly journals Undifferentiated Carcinoma With Osteoclastic Giant Cells (UCOCGC) of the Pancreas Associated With the Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

2008 ◽  
Vol 32 (12) ◽  
pp. 1905-1909 ◽  
Author(s):  
Jan-Bart M. Koorstra ◽  
Anirban Maitra ◽  
Folkert H. M. Morsink ◽  
Paul Drillenburg ◽  
Fiebo J. W. ten Kate ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma

18F-FDG PET/CT in the Detection of Undifferentiated Carcinoma With Osteoclast-like Giant Cells of the Pancreas

2017 ◽  
Vol 42 (8) ◽  
pp. 615-616 ◽  
Author(s):  
Li-ping Fu ◽  
Ai-ping Cheng ◽  
Xiao-gang Wang ◽  
Jian-lan Fu ◽  
Li Jin
Keyword(s):  
Fdg Pet ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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