Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a challenging cancer with new horizons?

2021 ◽  
Author(s):  
Claudio Luchini
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Carcinoma Of The Pancreas ◽  
New Horizons

scholarly journals Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

2021 ◽  
Vol 11 ◽  
Author(s):  
Pieter Demetter ◽  
Raphaël Maréchal ◽  
Francesco Puleo ◽  
Myriam Delhaye ◽  
Sébastien Debroux ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Who Classification ◽  
Current Knowledge ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Rare Tumor ◽  
Carcinoma Of The Pancreas ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Histological Appearance ◽  
Worse Prognosis

Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

scholarly journals Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells

2011 ◽  
Vol 81 (2) ◽  
pp. 146 ◽  
Author(s):  
Young Hoe Hur ◽  
Ho Hyun Kim ◽  
Jin Shick Seoung ◽  
Kyoung Won Seo ◽  
Jin Woong Kim ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Carcinoma Of The Pancreas

scholarly journals Case of Six-Year Disease-Free Survival with Undifferentiated Carcinoma of the Pancreas

2016 ◽  
Vol 10 (2) ◽  
pp. 472-478 ◽  
Author(s):  
Hiroyuki Saito ◽  
Hiroshi Kashiyama ◽  
Takashi Murohashi ◽  
Kazunari Sasaki ◽  
Ryosuke Misawa ◽  
...  
Keyword(s):  
Mixed Type ◽  
Disease Free Survival ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Maintenance Chemotherapy ◽  
Free Survival ◽  
Carcinoma Of The Pancreas ◽  
Dismal Prognosis ◽  
Diaphragmatic Invasion ◽  
Disease Free

Undifferentiated carcinoma of the pancreas (UDC) is rare and has a dismal prognosis. Here, we report a case of 6-year disease-free survival with a mixed type of UDC and UDC with osteoclast-like giant cells, with a high mitotic index as well as perineural, lymphatic, vessel, and diaphragmatic invasion. The patient underwent radical distal pancreatectomy and was subsequently treated with adjuvant chemotherapy using gemcitabine plus S-1 followed by maintenance chemotherapy with oral tegafur-uracil. The patient has been doing well with no evidence of recurrence for more than 6 years after surgery.

scholarly journals S1461 Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells

2020 ◽  
Vol 115 (1) ◽  
pp. S694-S694
Author(s):  
Juan J. Castano ◽  
Mohammed Shakhatreh ◽  
Grigoriy L. Rapoport ◽  
Henry Herrera
Keyword(s):  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Carcinoma Of The Pancreas
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