scholarly journals A smooth muscle‐derived, Braf ‐driven mouse model of gastrointestinal stromal tumor ( GIST ): evidence for an alternative GIST cell‐of‐origin

2020 ◽  
Vol 252 (4) ◽  
pp. 441-450
Author(s):  
Jumpei Kondo ◽  
Won Jae Huh ◽  
Jeffrey L Franklin ◽  
Michael C Heinrich ◽  
Brian P Rubin ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Cell Of Origin

Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

scholarly journals Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor

2006 ◽  
Vol 103 (34) ◽  
pp. 12843-12848 ◽  
Author(s):  
F. Rossi ◽  
I. Ehlers ◽  
V. Agosti ◽  
N. D. Socci ◽  
A. Viale ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Therapeutic Intervention ◽  
Stromal Tumor

A Knock-In Mouse Model of Gastrointestinal Stromal Tumor Harboring Kit K641E

2005 ◽  
Vol 65 (15) ◽  
pp. 6631-6639 ◽  
Author(s):  
Brian P. Rubin ◽  
Cristina R. Antonescu ◽  
James P. Scott-Browne ◽  
Melissa L. Comstock ◽  
Yansong Gu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor

scholarly journals The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor

Oncogene ◽  
2020 ◽  
Vol 39 (49) ◽  
pp. 7153-7165
Author(s):  
Jennifer Q. Zhang ◽  
Benedikt Bosbach ◽  
Jennifer K. Loo ◽  
Gerardo A. Vitiello ◽  
Shan Zeng ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Kit Mutation

scholarly journals Gastrointestinal Stromal Tumor

2016 ◽  
Vol 1 (3) ◽  
pp. 185-192
Author(s):  
Evi Christina Lingga ◽  
Arif Faisal
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Medical Technology ◽  
Stromal Tumor ◽  
Smooth Muscle Tumors ◽  
Technology Improvement

The gastrointestnal stromal tumor (GIST) is a gastrointestnal tract tumor, previously known as the group of smooth muscle tumors. By using medical technology improvement, GIST is shown as nonepitelial tumor that can arise along gastrointestnal tract. A patent with gastric disorder had been hospitalized multple tmes is reported. Defnitve diagnosis was delayed due to inappropriate applicaton of imaging diagnostic modalites, and the best treatment for the patent could not be done earlier.

Undifferentiated Mesenchymal Neoplasm of the Esophagus in a Child: Case Report and Comparison with Gastrointestinal Stromal Tumor

2003 ◽  
Vol 6 (3) ◽  
pp. 257-260 ◽  
Author(s):  
Jason V. Jollimore ◽  
Mohammed Zamakhshary ◽  
Michael Giacomantonio ◽  
Weiming Yu
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Distal Esophagus ◽  
Stromal Tumor ◽  
Childhood Tumors ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Tumors ◽  
Mesenchymal Neoplasm

Mesenchymal neoplasms of the esophagus are relatively uncommon in adults and exceedingly rare in children. Childhood tumors consist almost exclusively of smooth muscle tumors (leiomyomas). We report a case of an undifferentiated mesenchymal neoplasm occurring in the distal esophagus of a 15-year-old boy which is not a gastrointestinal stromal tumor. To our knowledge, this is the first reported case of such a neoplasm occurring in the esophagus of either an adult or child.

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