Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

Undifferentiated Mesenchymal Neoplasm of the Esophagus in a Child: Case Report and Comparison with Gastrointestinal Stromal Tumor

2003 ◽  
Vol 6 (3) ◽  
pp. 257-260 ◽  
Author(s):  
Jason V. Jollimore ◽  
Mohammed Zamakhshary ◽  
Michael Giacomantonio ◽  
Weiming Yu
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Distal Esophagus ◽  
Stromal Tumor ◽  
Childhood Tumors ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Tumors ◽  
Mesenchymal Neoplasm

Mesenchymal neoplasms of the esophagus are relatively uncommon in adults and exceedingly rare in children. Childhood tumors consist almost exclusively of smooth muscle tumors (leiomyomas). We report a case of an undifferentiated mesenchymal neoplasm occurring in the distal esophagus of a 15-year-old boy which is not a gastrointestinal stromal tumor. To our knowledge, this is the first reported case of such a neoplasm occurring in the esophagus of either an adult or child.

Leiomyoma with Bizarre Nuclei (Symplastic Leiomyoma) in the Paratubal Cyst Wall: Report of a Rare Case

2021 ◽  
pp. 106689692199779
Author(s):  
Murat Celik
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Cyst Wall ◽  
Rare Case ◽  
Clinical Behavior ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Neoplasm ◽  
Histological Variants ◽  
Eosinophilic Cytoplasm ◽  
Paratubal Cyst

Leiomyoma is a benign mesenchymal tumor that develops from smooth muscle cells. It can present in various histological variants. Leiomyoma with bizarre nuclei is an infrequent variant of uterine smooth muscle neoplasm. It is characterized by focally or diffusely distributed bizarre cells on the background of a typical leiomyoma. These bizarre cells are large, multinucleated, or multilobulated and have an eosinophilic cytoplasm. Even though leiomyomas with bizarre nuclei display benign clinical behavior, their differential diagnosis from leiomyosarcoma can sometimes be difficult. Leiomyoma has been described most commonly in the uterus. There is no case of leiomyoma originating from paratubal cysts described in the literature. In this article, we present a rare case of leiomyoma with bizarre nuclei originating from a paratubal cyst.

scholarly journals Gastric schwannoma: a benign tumor often misdiagnosed as gastrointestinal stromal tumor

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Apurva S. Shah ◽  
Pravin M. Rathi ◽  
Vaibhav S. Somani ◽  
Astha M. Mulani
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Rare Case ◽  
Benign Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Gastric Schwannoma ◽  
Gastric Mass

Gastric schwannomas are rare mesenchymal tumors that arise from the nerve plexus of gut wall. They present with nonspecific symptoms and are often detected incidentally. Preoperative investigation is not pathognomic and many are therefore misdiagnosed as gastrointestinal stromal tumors. We report a rare case of a 37-year old woman who underwent laparotomy for complex bilateral ovarian cyst with resection of gastric-gastrointestinal stromal tumor preoperatively, but confirmed to have a gastric schwannomas postoperatively. This case underscores the differential diagnosis of submucosal, exophytic gastric mass as schwannoma.

Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor

2020 ◽  
Vol 46 ◽  
pp. 151527
Author(s):  
Bohuslava Vankova ◽  
Kristyna Behenska ◽  
Meret Bauer ◽  
Monika Sedivcova ◽  
Magdalena Daumova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Undifferentiated Carcinoma ◽  
Morphological Features ◽  
Stromal Tumor

scholarly journals Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

2012 ◽  
Vol 6 ◽  
pp. CMO.S9180 ◽  
Author(s):  
Claudio Casella ◽  
Vincenzo Villanacci ◽  
Filippo D'adda ◽  
Manuela Codazzi ◽  
Bruno Salerni
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Radiological Evaluation ◽  
Retroperitoneal Mass ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Paravertebral Region ◽  
Histology And Immunohistochemistry

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery and retroperitoneum) and are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). EGISTs arising in the retroperitoneum are extremely rare: to date, only 58 cases have been reported in the literature. Case Report We herein report a case of a primary EGIST of the retroperitoneum surgically treated. The pre-operative radiological evaluation showed a retroperitoneal mass, placed in left paravertebral region. Results Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor (intermediate-low risk form). Conclusions As a result of the rarity of reports of primary EGISTs of retroperitoneum we need to analyze the data of reported cases in order to gain a better understanding about the pathogenesis, prognosis and optimal treatment of this disease.

scholarly journals A smooth muscle‐derived, Braf ‐driven mouse model of gastrointestinal stromal tumor ( GIST ): evidence for an alternative GIST cell‐of‐origin

2020 ◽  
Vol 252 (4) ◽  
pp. 441-450
Author(s):  
Jumpei Kondo ◽  
Won Jae Huh ◽  
Jeffrey L Franklin ◽  
Michael C Heinrich ◽  
Brian P Rubin ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Cell Of Origin

scholarly journals Giant gastrointestinal stromal tumor of ileum: the gist of GIST: a case report

2017 ◽  
Vol 4 (3) ◽  
pp. 1096
Author(s):  
M. S. Ray ◽  
B. S. Deepak
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Standard Of Care ◽  
Clinical Situation ◽  
Stromal Tumor ◽  
Curative Therapy ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms

Gastrointestinal stromal tumors (GIST) are relatively rare pathology as compared with other mitotic lesions of GIT. However, GIST is the most common mesenchymal neoplasms of the gastrointestinal tract. Biopsy of the lesion and Immuno-Histo-Chemistry (IHC) for CD117 confirms the diagnosis. Surgery remains the standard of care and only potentially curative therapy for patients with primary, resectable, localized gastrointestinal stromal tumor. However, chemotherapy with Imatinib is added in neoadjuvant or adjuvant form according to clinical situation, and histopathological status of the lesion.

scholarly journals Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms

2018 ◽  
Vol 82 ◽  
pp. 46-50
Author(s):  
Zhichun Lu ◽  
Khaleel Al-Obaidy ◽  
Liang Cheng ◽  
Kyle D. Perry ◽  
David J. Grignon ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Interstitial Cell ◽  
Cell Tumor ◽  
Mesenchymal Neoplasms

scholarly journals Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor

2017 ◽  
Vol 46 (2) ◽  
pp. 663-674 ◽  
Author(s):  
Chao Sun ◽  
Junkai Zou ◽  
Qing Wang ◽  
Qi Wang ◽  
Lu Han ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
English Language ◽  
External Genitalia ◽  
Surgical Excision ◽  
Smooth Muscle Tumor ◽  
Final Diagnosis ◽  
Diagnosis And Therapy ◽  
Long Term Follow Up ◽  
Muscle Tumor

The objective of this article is to discuss the pathophysiology, diagnosis, differential diagnosis, and therapy of vulvar leiomyoma. We performed a review of all English-language reports of vulvar leiomyoma published in PubMed from 1978 to 2015 using the following search terms: “vulval leiomyoma,” “vulvar leiomyoma,” “vulval smooth muscle tumor,” and “external genitalia smooth muscle tumor.” Vulvar leiomyomas, which are rare benign monoclonal tumors, most commonly occur in the fourth and fifth decades of life. The genetics of vulvar leiomyoma remain undefined. Three principal histological patterns have been identified: spindled, epithelioid, and myxoid. Imaging tests such as ultrasound, endoscopic ultrasound, and magnetic resonance imaging are used in diagnosis. Surgical excision is the only curative treatment for vulvar leiomyomas. Establishment of a full differential diagnosis list and correct final diagnosis before surgery are essential for optimal clinical management. Although recurrence of vulvar leiomyoma is extremely rare, long-term follow-up of all cases is advisable.

Sign in / Sign up

Export Citation Format

Share Document