Early distant relapse in ?node-negative? breast cancer patients is not predicted by occult axillary lymph node metastases, but by the features of the primary tumour

2001 ◽  
Vol 193 (4) ◽  
pp. 442-449 ◽  
Author(s):  
Cecile Colpaert ◽  
Peter Vermeulen ◽  
Wino Jeuris ◽  
Paul van Beest ◽  
Gerda Goovaerts ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Primary Tumour ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Axillary Lymph Node Metastases ◽  
Node Negative ◽  
Distant Relapse ◽  
Node Negative Breast Cancer ◽  
Node Metastases

Are Breast Cancer Nomograms Still Valid to Predict the Need for Axillary Dissection?

Oncology ◽  
2021 ◽  
pp. 1-5
Author(s):  
Vilma Madekivi ◽  
Antti Karlsson ◽  
Pia Boström ◽  
Eeva Salminen
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Dissection ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Axillary Lymph Node Metastases ◽  
Node Negative ◽  
Node Metastases ◽  
External Population

Background: Nomograms can help in estimating the nodal status among clinically node-negative patients. Yet their validity in external cohorts over time is unknown. If the nodal stage can be estimated preoperatively, the need for axillary dissection can be decided. Objectives: The aim of this study was to validate three existing nomograms predicting 4 or more axillary lymph node metastases. Method: The risk for ≥4 lymph node metastases was calculated for n = 529 eligible breast cancer patients using the nomograms of Chagpar et al. [Ann Surg Oncol. 2007;14:670–7], Katz et al. [J Clin Oncol. 2008;26(13):2093–8], and Meretoja et al. [Breast Cancer Res Treat. 2013;138(3):817–27]. Discrimination and calibration were calculated for each nomogram to determine their validity. Results: In this cohort, the AUC values for the Chagpar, Katz, and Meretoja models were 0.79 (95% CI 0.74–0.83), 0.87 (95% CI 0.83–0.91), and 0.82 (95% CI 0.76–0.86), respectively, showing good discrimination between patients with and without high nodal burdens. Conclusion: This study presents support for the use of older breast cancer nomograms and confirms their current validity in an external population.

scholarly journals Immunohistochemical detection of axillary lymph node micrometastases in node negative breast cancer patients using cytokeratin and epithelial membrane antigen

2015 ◽  
Vol 04 (01) ◽  
pp. 028-031 ◽  
Author(s):  
Monisha Choudhury ◽  
Sapna Agrawal ◽  
Mukta Pujani ◽  
Shaji Thomas ◽  
Meenu Pujani
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Node Negative ◽  
Occult Metastases ◽  
Node Negative Breast Cancer ◽  
Node Metastases

Abstract Background and Objective: The study was conducted to detect occult metastases in lymph node negative breast cancer patients using cytokeratin (CK) and epithelial membrane antigen (EMA) immunohistochemistry (IHC) and correlate this with primary tumor size and grade. Materials and Methods: A total of 32 cases including 12 prospective and 20 retrospective cases of axillary lymph node negative breast cancer were studied. CK and EMA IHC were performed to detect micrometastases. Results: Axillary lymph node metastases were detected in 18.75% of previously node negative cases using CK and EMA IHC. CK was found to be more sensitive for detection of metastases compared to EMA. A highly significant correlation was observed between tumor grade and axillary lymph node metastases detected by CK and EMA. However, no significant correlation was found between tumor size and axillary lymph node metastases detected by IHC. Conclusion: In the present study, there was an increase of 18.75% in the occult metastases detection rate using CK and EMA. To conclude, IHC detection of occult metastases should be done using CK in all axillary node negative cases, especially in T1 and T2 stage tumors.

Predictors for extensive nodal involvement in breast cancer patients with axillary lymph node metastases

The Breast ◽  
2016 ◽  
Vol 27 ◽  
pp. 175-181 ◽  
Author(s):  
N.C. Verheuvel ◽  
H.W.A. Ooms ◽  
V.C.G. Tjan-Heijnen ◽  
R.M.H. Roumen ◽  
A.C. Voogd
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Nodal Involvement ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases

scholarly journals Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1–3 lymph node metastases

Breast Cancer ◽  
2012 ◽  
Vol 21 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Tomohiro Nogami ◽  
Tadahiko Shien ◽  
Takehiro Tanaka ◽  
Keiko Nishiyama ◽  
Taeko Mizoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Clinical Outcome ◽  
Lymph Node Metastases ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Poor Clinical Outcome ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases

P313 A new predictive score for axillary lymph node metastases in breast cancer patients

The Breast ◽  
2015 ◽  
Vol 24 ◽  
pp. S134
Author(s):  
T. Ogura ◽  
T. Kinoshita ◽  
K. Jimbo ◽  
S. Asaga ◽  
T. Hojo
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Predictive Score ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases
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