Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth

2008 ◽  
Vol 50 (5) ◽  
pp. 1075-1077 ◽  
Author(s):  
Veronica H. Flood ◽  
Faith C. Galderisi ◽  
Stefanie R. Lowas ◽  
Angela Kendrick ◽  
Lynn K. Boshkov
Keyword(s):  
Vitamin K ◽  
Hemorrhagic Disease ◽  
Vitamin K Prophylaxis

Comparison of oral and parenteral vitamin K prophylaxis for prevention of late hemorrhagic disease of the newborn

1991 ◽  
Vol 119 (3) ◽  
pp. 461-464 ◽  
Author(s):  
William E. Hathaway ◽  
P.B. Isarangkura ◽  
C. Mahasandana ◽  
L. Jacobson ◽  
P. Pintadit ◽  
...  
Keyword(s):  
Vitamin K ◽  
Hemorrhagic Disease ◽  
Vitamin K Prophylaxis

scholarly journals INTRACEREBRAL BLEEDING IN LATE HEMORRHAGIC DISEASE OF THE NEWBORN

2019 ◽  
pp. 1-2
Author(s):  
Jayashree Nadkarni
Keyword(s):  
Vitamin K ◽  
Task Force ◽  
Current Status ◽  
Hemorrhagic Disease ◽  
Current Guideline ◽  
Vitamin K Deficiency ◽  
Vitamin K Deficiency Bleeding ◽  
Vitamin K Prophylaxis ◽  
New Born ◽  
K Deficiency

1 Vitamin K Ad Hoc Task Force. Controversies concerning vitamin K and the newborn. Pediatrics 1993; 91: 1001-1003. 2. Isarangkura PB, Pintadit P, Tejavej A, Siripoonya P. Chulajata C, Green GM. Vitamin K prophylaxis in the neonate by oral route and its significance in reducing infant mortality and morbidity. J Med Assoc Thai 1986; 69: 56-61. 3. Ijland MM, Pereira RR, Cornelissen EA. Incidence of late vitamin K deficiency bleeding in new-borns in the Netherlands in 2005: Evaluation of the current guideline. Eur J Paediatr 2008; 167: 165-169. 4. Waseem M. Vitamin K and hemorrhagic disease of new-borns. South Med J 2006; 99: 1199. 5. Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr 1985; 106: 351-359. 6. Singh M. Vitamin K during infancy: Current status and recommendations.Indian Pediatr 1997; 34: 708-712. 7. Bor O, Akgun N, Yakut A, et al. Late hemorrhagic disease of the new-born.Paediatr Int 2000; 42: 64-66. 8. D?Souza IE, Rao SD. Late hemorrhagic disease of new-born. Indian Paediatr 2003; 40: 226-229. 9. Flood VH, Galderisi FC, Lowas SR, et al. Hemorrhagic disease of the new-born despite vitamin K prophylaxis at birth. Paediatr Blood Cancer 2008; 50: 1075-1077. 10. Zengin E, Sarper N, Türker G, et al. Late haemorrhagic disease of the new- born. Ann Trop Paediatr 2006; 26: 225-231. 11. Sutor AH, Dagres N, Niederhoff H. Late form of vitamin K deficiency bleeding in Germany. KlinPediatr 1995; 207: 89-97

Controversies Concerning Vitamin K and the Newborn

PEDIATRICS ◽  
1993 ◽  
Vol 91 (5) ◽  
pp. 1001-1002
Author(s):  
Keyword(s):  
Vitamin K ◽  
Standard Of Care ◽  
Repeated Administration ◽  
Similar Efficacy ◽  
Hemorrhagic Disease ◽  
Vitamin K Deficiency ◽  
Oral Vitamin ◽  
Vitamin K Prophylaxis ◽  
K Deficiency ◽  
Risk Of Cancer

Vitamin K deficiency may cause unexpected bleeding (0.25% to 1.7% incidence) during the first week of life in previously healthy-appearing neonates (classic hemorrhagic disease of the newborn [HDN]). The efficacy of neonatal vitamin K prophylaxis (either oral or parenteral) in the prevention of classic HDN is firmly established. It has been the standard of care since the recommendation by the Committee on Nutrition was adopted as policy by the American Academy of Pediatrics in 19611 Late HDN, a syndrome defined as unexpected bleeding due to severe vitamin K deficiency in infants aged 2 to 12 weeks, occurs primarily in exclusively breast-fed infants who have received no or inadequate neonatal vitamin K prophylaxis. In addition, infants who have intestinal malabsorption defects (cholestatic jaundice, cystic fibrosis, etc) may also present with late HDN. The rate of late HDN (often manifested by sudden central nervous system hemorrhage) ranges from 4.4 to 7.2 per 100 000 births based on reports from Europe and Asia. When a single dose of oral vitamin K has been used as neonatal prophylaxis, the rate has decreased to 1.4 to 6.4 per 100 000 births. Parenteral neonatal vitamin K prophylaxis prevents the development of late HDN, with the rare exception of infants with severe malabsorption syndromes. Oral regimens that have a similar efficacy as parenteral vitamin K in prevention of late HDN include the repeated administration of oral vitamin K1 (Germany) or K2 (Japan) at birth, 1 week, and 2 to 4 weeks. In 1990 Golding et al2 reported a study of a 1970 birth cohort in Britain in which they noted an unexpected association between childhood cancer and pethidine given in labor and the neonatal administration of vitamin K. Subsequently, Golding and others3 conducted a case-control study designed to examine the risk of cancer associated with intramuscular vitamin K administration among infants born in two hospitals in Avon between 1965 and 1987 and diagnosed with cancer between 1971 and 1989.

Late Hemorrhagic Disease of the Newborn: A Fatal Presentation of Hepatobiliary Disease Masquerading as Shaken Baby Syndrome

1995 ◽  
Vol 10 (6) ◽  
pp. 315-318 ◽  
Author(s):  
Sam Shemie ◽  
Ernest Cutz
Keyword(s):  
Intracranial Hemorrhage ◽  
Vitamin K ◽  
Fatal Case ◽  
Shaken Baby Syndrome ◽  
Hepatobiliary Disease ◽  
Hemorrhagic Disease ◽  
Vitamin K Prophylaxis ◽  
History Of ◽  
Breast Fed ◽  
Rule Out

Late hemorrhagic disease of newborns classically presents with intracranial hemorrhage in breast-fed infants who have not received vitamin K prophylaxis. We report a fatal case of vitamin K-deficient coagulopathy in a formula-fed infant who received parenteral vitamin K. This catastrophic presentation, initially mistaken for child abuse because of the associated retinal hemorrhages, revealed a previously unrecognized hepatobiliary disease. Infants presenting with intracranial hemorrhage and coagulopathy with a history of parenteral vitamin K prophylaxis should undergo appropriate investigation to rule out underlying liver pathology.

Is Single Dose of Vitamin K Prophylaxis Sufficient in Newborn Infant for the Prevention of Hemorrhagic Disease? Two Case Report

2012 ◽  
Vol 28 (3) ◽  
pp. 162-166 ◽  
Author(s):  
Yelda Turkmenoglu ◽  
Burcu Tufan Tas ◽  
Emine Turkkan ◽  
Fatma Nesil Aydinol ◽  
İhsan Kafadar ◽  
...  
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Newborn Infant ◽  
Vitamin K ◽  
Hemorrhagic Disease ◽  
Vitamin K Prophylaxis

Fatal Intracranial Hemorrhage in a Normal Infant Secondary to Vitamin K Deficiency

PEDIATRICS ◽  
1983 ◽  
Vol 72 (4) ◽  
pp. 562-564
Author(s):  
PETER A. LANE ◽  
WILLIAM E. HATHAWAY ◽  
JOHN H. GITHENS ◽  
RICHARD D. KRUGMAN ◽  
DONNA A. ROSENBERG
Keyword(s):  
Vitamin K ◽  
Correct Diagnosis ◽  
Fatal Case ◽  
Male Infant ◽  
Hemorrhagic Disease ◽  
Normal Infant ◽  
Vitamin K Deficiency ◽  
Hospital Emergency Room ◽  
History Of ◽  
K Deficiency

Since the initiation of routine vitamin K prophylaxis in newborns, the incidence of hemorrhagic disease of the newborn has been dramatically decreased. Recently there have been suggestions in the literature that prophylaxis may be unnecessary.1-4 We report here a fatal case of vitamin K deficiency in an otherwise healthy 1-month-old who did not receive prophylaxis. This case is illustrative because the child was initially thought to have suffered nonaccidental trauma. In addition, the correct diagnosis was confirmed, retrospectively, after vitamin K administration, with new assays for vitamin K-deficient prothrombin. CASE REPORT This 4-week-old male infant was seen at a community hospital emergency room with a one-day history of irritability, poor feeding, and decreased responsiveness without fever.

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