scholarly journals Plasma exchange therapy for acute necrotizing encephalopathy of childhood

2021 ◽  
Vol 5 (2) ◽  
pp. 99-105
Author(s):  
Kechun Li ◽  
Tao Zhang ◽  
Gang Liu ◽  
Ping Jin ◽  
Yeqing Wang ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Acute Necrotizing Encephalopathy ◽  
Plasma Exchange Therapy ◽  
Acute Necrotizing

Recurrent Acute Necrotizing Encephalopathy Responsive to Early Steroid-Treatment

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
T Schmitt-Mechelke
Keyword(s):  
Steroid Treatment ◽  
Acute Necrotizing Encephalopathy ◽  
Acute Necrotizing

scholarly journals Rhabdomyolysis and acute renal failure in acute necrotizing encephalopathy with influenza A

1998 ◽  
Vol 12 (1) ◽  
pp. 85-85
Author(s):  
Toru Watanabe ◽  
Yoshihiko Oda
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Influenza A ◽  
Acute Necrotizing Encephalopathy ◽  
Acute Necrotizing

Excellent Outcome of Acute Necrotizing Encephalopathy in an Adult With Bacterial Infections, Case Report

2021 ◽  
pp. 194187442199137
Author(s):  
Yan Wang ◽  
John R. Younce ◽  
Joel S. Perlmutter ◽  
Soe S. Mar
Keyword(s):  
Differential Diagnosis ◽  
Bacterial Infections ◽  
Vasogenic Edema ◽  
Brain Magnetic Resonance Imaging ◽  
Acute Necrotizing Encephalopathy ◽  
Excellent Outcome ◽  
Intravenous Antibiotics ◽  
Acute Necrotizing ◽  
Supportive Management

Acute necrotizing encephalopathy (ANE) is a rare para-infectious encephalopathy that classically occurs in children. However, ANE should be considered in the differential diagnosis of adults with symmetric brain lesions after a prodromal illness given recent reports of coronavirus disease of 2019 (COVID-19) to presumably cause ANE in adults. We report a case of a 29-year-old male presenting with fever, malaise, and rapid deterioration into coma. Brain magnetic resonance imaging revealed multifocal symmetric areas of diffusion restriction and surrounding vasogenic edema involving bilateral thalami, pons and cerebellar hemispheres with a core of susceptibility artifact, and minimal thalamic contrast enhancement, most consistent with ANE. Extensive infectious workup revealed isolated Escherichia coli and Neisseria gonorrhoeae in his urine. Despite the severe encephalopathy on initial presentation, the patient improved with intravenous antibiotics and supportive management with minimal residual deficits at 9 months follow-up. We aim to provide an overview of the radiological features, differential diagnosis, treatment and prognosis of ANE. Becoming familiarized with this rare but devastating disease will improve detection, treatment, and ultimately prognosis, especially in the era of a new pandemic.

scholarly journals AB0444 THROMBOTIC MICROANGIOPATHY AND SJÖGREN SYNDROME, AN UNUSUAL ASSOCIATION. PRESENTATION OF CLINICAL CASE AND SYSTEMATIC REVIEW OF THE LITERATURE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1521.2-1521
Author(s):  
Y. Santamaria ◽  
M. Galvis ◽  
A. Vanegas
Keyword(s):  
Hospital Admission ◽  
Plasma Exchange ◽  
Thrombotic Microangiopathy ◽  
Clinical Case ◽  
Medical Literature ◽  
Sjogren Syndrome ◽  
Plasma Exchange Therapy ◽  
History Of ◽  
The Mean ◽  
Intravenous Steroids

Background:Thrombotic microangiopathy (TMA) is a clinicopathologic diagnosis defined as microangiopathic hemolytic anemia (MAHA) with associated features of thrombocytopenia and end-organ ischemia. Systemic lupus erythematosus, antiphospholipid antibody syndrome, and scleroderma, are within the autoimmune diseases, the more commonly associated with TMA. It has been considered that the association with Sjögren Syndrome (SS) is rare.Objectives:To describe one patient with TMA and SS, and to review all cases reported in the literature.Methods:We notified a clinical case of a patient with Sjögren’s syndrome and TMA. Then, we searched the medical literature finding a total of 17 cases reported with this association until 2019. Before the data obtained were tabulated by trained staff and descriptive, comparing groups and bivariate analysis was performed. The outcome of interest was the death of the patient. Stata 12.0 software was used.Results:A 26-years-old Colombian female presented with a 6-week history of petechiae in lower limbs, gingivorrhagia, menorrhagia and jaundice; and previous history of arthritis and xerostomia. On admission, in the context of severe thrombocytopenia and MAHA, MAT diagnosis was made. During hospitalization we confirm the diagnosis of SS with ANA, antiRo and salivary gland biopsy. The patient was treated with steroids (methylprednisolone 500 mg/day, 3 days), plasma exchange therapy (PLEX) and Cyclophosphamide (750 mg), with recovery of hemoglobin and platelet levels; however, the patient died due to a complication of the PLEX catheter removal procedure.A total of 18 patients diagnosed with de novo or prevalent Sjögren’s syndrome who had hospital admission with a diagnosis of TMA were included. The mean age was 54.55 years (Standard deviation (SD): 12.45) and 83.33% of the patients corresponded to the female gender.At admission, the mean of hemoglobin was 8.45 g/dL (SD: 2.55) and median platelets of 27250/mm3 (interquartile range (IQR) 10500 - 102000) were found. The most frequent clinical manifestations were central nervous system alterations (50%), followed by bleeding in the skin and renal failure (44.44%) and fever (27.78%). The most frequent antibodies found were anti-Ro (100%), anti-nuclear antibodies (80%) and anti-La (75%). The most frequently prescribed treatment was plasma exchange therapy (83.33%), intravenous steroids (61.11%), oral steroids (61.11%) and cyclophosphamide (27.78%). Of the total patients, 38.89% died and 27.7% had some relapse of TMA.In the group comparison analysis, differences were found in intravenous steroid (81.82% in those who lived vs. 28.57% in those who died p=0.039), use of PLEX (100% in those who survived vs. 57.14% in those who died p = 0.043), fever (9.09% in those who survived and 57.14% in those who died, p = 0.047), admission hemoglobin (7.65 g/dL in those who lived vs. 10.22 g/dL in those who died, p = 0.05), final platelets (148,000 in which who lived and 39,000 in those who died p = 0.02). Then, in the logistic regression analysis, an association was found between mortality and use of intravenous steroids (OR: 0.08, 95% CI 0.009 - 0.83, p = 0.35) and fever at admission (OR: 13.33 95% CI: 1.04 - 169.55, p = 0.046).Conclusion:While the association between TMA and SS is uncommon, so far 18 cases have been reported in the world medical literature. It is typically a condition of women age close to 50 years. The most frequent manifestations are neurological. Among the variables evaluated, only the use of endovenous steroids was associated with a decrease in the probability of mortality; on the contrary, the presence of fever at hospital admission increased the probability of death. The results should be evaluated with caution, since, due to the limited availability of information, they may not be generalizable to clinical practice. More information on this should be obtained in the future.Disclosure of Interests:None declared

Acute necrotizing encephalopathy of childhood associated with human herpes virus 6 in Croatia

2018 ◽  
Vol 40 (3) ◽  
pp. 639-641 ◽  
Author(s):  
Vedran Stevanović ◽  
Zoran Barušić ◽  
Klaudija Višković ◽  
Oktavija Đaković Rode ◽  
Goran Tešović
Keyword(s):  
Herpes Virus ◽  
Human Herpes ◽  
Acute Necrotizing Encephalopathy ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Acute Necrotizing ◽  
Herpès Virus

Blood plasma thermal behavior and protein oxidation as indicators of multiple sclerosis clinical status and plasma exchange therapy progression

2019 ◽  
Vol 671 ◽  
pp. 193-199 ◽  
Author(s):  
Boris Tenchov ◽  
Rumiana Koynova ◽  
Borislava Antonova ◽  
Stella Zaharinova ◽  
Silviya Abarova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Thermal Behavior ◽  
Blood Plasma ◽  
Plasma Exchange ◽  
Protein Oxidation ◽  
Clinical Status ◽  
Plasma Exchange Therapy

Pandemic Influenza A-Associated Acute Necrotizing Encephalopathy Without Neurologic Sequelae

2011 ◽  
Vol 45 (5) ◽  
pp. 344-346 ◽  
Author(s):  
Akira Kumakura ◽  
Chihiro Iida ◽  
Makiko Saito ◽  
Masashi Mizuguchi ◽  
Daisuke Hata
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Acute Necrotizing Encephalopathy ◽  
Neurologic Sequelae ◽  
Acute Necrotizing

scholarly journals Acute Necrotizing Encephalopathy

2019 ◽  
Vol 29 (07) ◽  
pp. 649-653 ◽  
Author(s):  
Farida Jan ◽  
Sidra Jafri ◽  
Shahnaz Ibrahim
Keyword(s):  
Acute Necrotizing Encephalopathy ◽  
Acute Necrotizing
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