pH-responsive poly(ethylene glycol)-poly(ϵ-caprolactone)-poly(glutamic acid) polymersome as an efficient doxorubicin carrier for cancer therapy

2017 ◽  
Vol 66 (11) ◽  
pp. 1579-1586 ◽  
Author(s):  
Lanxia Zhao ◽  
Xia Zhang ◽  
Xin Liu ◽  
Juan Li ◽  
Yuxia Luan
Keyword(s):  
Cancer Therapy ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Doxorubicin Conjugate of Poly(Ethylene Glycol)-Block-Polyphosphoester for Cancer Therapy

2013 ◽  
Vol 3 (2) ◽  
pp. 261-272 ◽  
Author(s):  
Chun-Yang Sun ◽  
Shuang Dou ◽  
Jin-Zhi Du ◽  
Xian-Zhu Yang ◽  
Ya-Ping Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

One-shot synthesis and solution properties of ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate

2019 ◽  
Vol 10 (17) ◽  
pp. 2143-2151 ◽  
Author(s):  
Yan Zhang ◽  
Yue Xu ◽  
Chao Wei ◽  
Chuanhao Sun ◽  
Bingkun Yan ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Tertiary Amine ◽  
Solution Properties ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Amine Groups ◽  
Poly Ethylene

A one-shot method was employed to synthesize ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate (mPEG-b-poly(MN-co-MSe)) with the selenide and tertiary amine groups situated on the backbone.

Poly(γ-glutamic acid) modulates the properties of poly(ethylene glycol) hydrogel for biomedical applications

2016 ◽  
Vol 27 (18) ◽  
pp. 1775-1787 ◽  
Author(s):  
Weikang Hu ◽  
Xiaoreng Feng ◽  
Xin Liu ◽  
Shulin Dai ◽  
Wen Zeng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

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