scholarly journals WS21.3 Short-term effects of hypertonic saline nebulization combined with oscillatory positive expiratory pressure in cystic fibrosis: randomised crossover trial

2016 ◽  
Vol 15 ◽  
pp. S33 ◽  
Author(s):  
B. Herrero Cortina ◽  
M. San Miguel Pagola ◽  
M.À. Cebrià i Iranzo ◽  
M. Gomez Romero ◽  
F. Diaz Gutierrez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Crossover Trial ◽  
Short Term ◽  
Positive Expiratory Pressure ◽  
Short Term Effects

Hypertonic saline nebulization combined with oscillatory positive expiratory pressure accelerate sputum clearance in cystic fibrosis: A randomised crossover trial

2016 ◽  
Author(s):  
Marta San Miguel Pagola ◽  
Beatriz Herrero Cortina ◽  
Maria Àngels Cebrià i Iranzo ◽  
Marta Gómez Romero ◽  
Fernando Diaz Gutierrez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Crossover Trial ◽  
Positive Expiratory Pressure

Impact of hypertonic saline nebulisation combined with oscillatory positive expiratory pressure on sputum expectoration and related symptoms in cystic fibrosis: a randomised crossover trial

Physiotherapy ◽  
2020 ◽  
Vol 107 ◽  
pp. 243-251 ◽  
Author(s):  
Marta San Miguel-Pagola ◽  
Gregory Reychler ◽  
María A. Cebrià i Iranzo ◽  
Marta Gómez-Romero ◽  
Fernando Díaz-Gutiérrez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Crossover Trial ◽  
Positive Expiratory Pressure

scholarly journals A short-term evaluation of a prototype disposable Oscillating Positive Expiratory Pressure (OPEP) device in a cohort of children with cystic fibrosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin J. O’Sullivan ◽  
Valerie Power ◽  
Barry Linnane ◽  
Deirdre McGrath ◽  
Magdalena Mulligan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Clinical Investigation ◽  
Mean Difference ◽  
Short Term ◽  
Intervention Participant ◽  
Post Intervention ◽  
Convenience Sample ◽  
Disposable Device ◽  
Positive Expiratory Pressure

Abstract Background Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or often more frequent, cleaning to prevent risk of infection by acting as reservoirs of potentially pathogenic organisms. In response, a daily disposable OPEP device, the UL-OPEP, was developed to mitigate the risk of contamination and eliminate the burdensome need for cleaning devices. Methods A convenience sample of 36 participants, all current OPEP device users, was recruited from a paediatric CF service. For one month, participants replaced their current OPEP device with a novel daily disposable device. Assessment included pre- and post-intervention lung function by spirometry, as well as Lung Clearance Index. Quality of life was assessed using the Cystic Fibrosis Questionnaire – Revised, while user experience was evaluated with a post-study survey. Results 31 participants completed the study: 18 males; median age 10 years, range 4–16 years. Lung function (mean difference ± SD, %FEV1 = 1.69 ± 11.93; %FVC = 0.58 ± 10.04; FEV1: FVC = 0.01 ± 0.09), LCI (mean difference ± SD, 0.08 ± 1.13), six-minute walk test, and CFQ-R were unchanged post-intervention. Participant-reported experiences of the device were predominantly positive. Conclusions The disposable OPEP device maintained patients’ lung function during short term use (≤ 1 month), and was the subject of positive feedback regarding functionality while reducing the risk of airway contamination associated with ineffective cleaning. Registration The study was approved as a Clinical Investigation by the Irish Health Products Regulatory Authority (CRN-2209025-CI0085).

scholarly journals Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety

2011 ◽  
Vol 46 (7) ◽  
pp. 666-671 ◽  
Author(s):  
Margaret Rosenfeld ◽  
Stephanie Davis ◽  
Lyndia Brumback ◽  
Stephen Daniel ◽  
Ron Rowbotham ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Infants And Toddlers ◽  
Short Term ◽  
Term Tolerability

Short-Term Effects of Elastic Chest Wall Restriction on Pulmonary Function in Children with Cystic Fibrosis

Respiration ◽  
2018 ◽  
Vol 96 (6) ◽  
pp. 535-542 ◽  
Author(s):  
Katrin Roethlisberger ◽  
Sylvia Nyilas ◽  
Thomas Riedel ◽  
Jeremy Wolfensberger ◽  
Florian Singer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Chest Wall ◽  
Short Term ◽  
Short Term Effects

scholarly journals Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Bradley S. Quon ◽  
Andrew H. Ramsook ◽  
Satvir S. Dhillon ◽  
Reid A. Mitchell ◽  
Kyle G. Boyle ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Short Term ◽  
Ventilatory Responses ◽  
Short Term Effects

scholarly journals Effects of exercise and airway clearance (positive expiratory pressure) on mucus clearance in cystic fibrosis: a randomised crossover trial

2019 ◽  
Vol 53 (4) ◽  
pp. 1801793 ◽  
Author(s):  
Tiffany J. Dwyer ◽  
Evangelia Daviskas ◽  
Rahizan Zainuldin ◽  
Jordan Verschuer ◽  
Stefan Eberl ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Crossover Trial ◽  
Treadmill Exercise ◽  
Forced Expiratory Volume ◽  
Mean Difference ◽  
Peak Oxygen Consumption ◽  
Mucus Clearance ◽  
Airway Clearance ◽  
Positive Expiratory Pressure

Exercise improves mucus clearance in people without lung disease and those with chronic bronchitis. No study has investigated exercise alone for mucus clearance in cystic fibrosis (CF). The aim of this study was to compare the effects of treadmill exercise to resting breathing and airway clearance with positive expiratory pressure (PEP) therapy on mucus clearance in adults with CF.This 3-day randomised, controlled, crossover trial included 14 adults with mild to severe CF lung disease (forced expiratory volume in 1 s % predicted 31–113%). Interventions were 20 min of resting breathing (control), treadmill exercise at 60% of the participant's peak oxygen consumption or PEP therapy (including huffing and coughing). Mucus clearance was measured using the radioaerosol technique and gamma camera imaging.Treadmill exercise improved whole lung mucus clearance compared to resting breathing (mean difference 3%, 95% CI 2–4); however, exercise alone was less effective than PEP therapy (mean difference −7%, 95% CI −6– −8). When comparing treadmill exercise to PEP therapy, there were no significant differences in mucus clearance from the intermediate and peripheral lung regions, but significantly less clearance from the central lung region (likely reflecting the huffing and coughing that was only in PEP therapy).It is recommended that huffing and coughing are included to maximise mucus clearance with exercise.

scholarly journals Short-term effects of regular salmeterol treatment on adult cystic fibrosis patients

1997 ◽  
Vol 10 (10) ◽  
pp. 2307-2311 ◽  
Author(s):  
J. Bargon ◽  
K. Viel ◽  
N. Dauletbaev ◽  
R. Wiewrodt ◽  
R. Buhl
Keyword(s):  
Cystic Fibrosis ◽  
Short Term ◽  
Short Term Effects
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