scholarly journals The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

2017 ◽  
Vol 53 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Craig A. Williams ◽  
Owen W. Tomlinson ◽  
Lucy V. Chubbock ◽  
Daniel Stevens ◽  
Zoe L. Saynor ◽  
...  
2018 ◽  
Vol 17 ◽  
pp. S14 ◽  
Author(s):  
O.W. Tomlinson ◽  
A.R. Barker ◽  
L.V. Chubbock ◽  
D. Stevens ◽  
Z.L. Saynor ◽  
...  

2012 ◽  
Vol 44 (3) ◽  
pp. 428-434 ◽  
Author(s):  
SOPHIE ANTOINE-JONVILLE ◽  
AURÉLIEN PICHON ◽  
ALI VAZIR ◽  
MICHAEL I. POLKEY ◽  
MARK J. DAYER

2012 ◽  
Vol 24 (1) ◽  
pp. 129-141 ◽  
Author(s):  
Bart C. Bongers ◽  
Erik H.J. Hulzebos ◽  
Bert G.M. Arets ◽  
Tim Takken

Purpose: The oxygen uptake efficiency slope (OUES) has been proposed as an ‘effort-independent’ measure of cardiopulmonary exercise capacity, which could be used as an alternative measurement for peak oxygen uptake (VO2peak) in populations unable or unwilling to perform maximal exercise. The aim of the current study was to investigate the validity of the OUES in children with cystic fibrosis (CF). Methods: Exercise data of 22 children with CF and mild to moderate airflow obstruction were analyzed and compared with exercise data of 22 healthy children. The OUES was calculated using data up to three different relative exercise intensities, namely 50%, 75%, and 100% of the total exercise duration, and normalized for body surface area (BSA). Results: Only the OUES/BSA using the first 50% of the total exercise duration was significantly different between the groups. OUES/BSA values determined at different exercise intensities differed significantly within patients with CF and correlated only moderately with VO2peak and the ventilatory threshold. Conclusion: The OUES is not a valid submaximal measure of cardiopulmonary exercise capacity in children with mild to moderate CF, due to its limited distinguishing properties, its nonlinearity throughout progressive exercise, and its moderate correlation with VO2peak and the ventilatory threshold.


2010 ◽  
Vol 9 (5) ◽  
pp. 307-313 ◽  
Author(s):  
M. Gruet ◽  
J. Brisswalter ◽  
L. Mely ◽  
J.M. Vallier

2017 ◽  
Vol 49 (10) ◽  
pp. 1980-1986 ◽  
Author(s):  
OWEN WILLIAM TOMLINSON ◽  
ALAN ROBERT BARKER ◽  
PATRICK JOHN OADES ◽  
CRAIG ANTHONY WILLIAMS

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Jessica Scott ◽  
Elizabeth Goetchius ◽  
Roxanne Buxton ◽  
Lori Ploutz‐Snyder

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
C Crolow ◽  
W Ammenwerth ◽  
N Schönfeld ◽  
M Klemens ◽  
RC Bittner ◽  
...  

2012 ◽  
Vol 24 (3) ◽  
pp. 347-356 ◽  
Author(s):  
Michael P. Rogowski ◽  
Justin P. Guilkey ◽  
Brooke R. Stephens ◽  
Andrew S. Cole ◽  
Anthony D. Mahon

This study examined the influence of maturation on the oxygen uptake efficiency slope (OUES) in healthy male subjects. Seventy-six healthy male subjects (8–27 yr) were divided into groups based on maturation status: prepubertal (PP), midpubertal (MP), late-pubertal (LP), and young-adult (YA) males. Puberty status was determined by physical examination. Subjects performed a graded exercise test on a cycle ergometer to determine OUES. Group differences were assessed using a one-way ANOVA. OUES values (VO2L·min1/log10VEL·min−1) were lower in PP and MP compared with LP and YA (p < .05). When OUES was expressed relative to body mass (VO2mL·kg−1·min−1/log10VEmL·kg−1·min−1) differences between groups reversed whereby PP and MP had higher mass relative OUES values compared with LP and YA (p < .05). Adjusting OUES by measures of body mass failed to eliminate differences across maturational groups. This suggests that qualitative factors, perhaps related to oxidative metabolism, account for the responses observed in this study.


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