Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people

Athletes are advised to receive the COVID-19 vaccination to protect them from SARS CoV-2 infection during major competitions. Despite this, many athletes are reluctant to get the COVID-19 vaccine due to concerns that symptoms of vaccinosis may impair athletic performance. OBJECTIVE: To determine the effects of COVID-19 vaccination on the physiological responses to graded exercise. METHODS: Healthy physically active participants completed a 20-minute bout of graded cycling exercise at intensities corresponding to 50, 60, 70 and 80% of the pre-determined V̇O2max before and ~21 days after receiving the COVID-19 vaccine (2 dose Pfizer mRNA or 1 dose Johnson&Johnson). RESULTS: Vaccination had no effect on a large number of physiological responses to exercise measured in blood (e.g. lactate, epinephrine, cortisol) and by respiratory gas exchange (e.g. oxygen uptake, CO2 production, ventilation, respiratory exchange ratio, predicted V̇O2max, ventilatory threshold) (p>0.05). We did, however, find significant elevations in heart rate (~5 bpm) and norepinephrine (p = 0.006 and 0.04, respectively) in response to vigorous (e.g. 70-80% V̇O2max) intensity exercise after vaccination, particularly in those that received the two shot Pfizer mRNA vaccine regimen. These findings held true when compared to demographically matched controls who completed identical bouts of exercise several weeks apart without receiving a vaccine. CONCLUSION: Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people. The small elevations in cardiovascular and neuroendocrine responses to exercise after the Pfizer mRNA vaccine regimen could have implications for athletes at the elite level and warrants investigation.

Sensitivity of cycling Motion Performance Indicators (MPIs) to incremented load and their relationship with performance in professional cyclists

There is a lack of research assessing Motion Performance Indicators (MPIs), which have been recently made commercially available. Therefore, this study explored: (1) the influence of incremented exercise on MPIs and; (2) the relationships between MPIs and cycling performance at different intensities during a graded exercise test (GXT) in professional cyclists. Thirty-six professional cyclists performed GXT until exhaustion with their own bikes attached to a cycle ergometer. MPIs were collected using a real-time motion capture system based on inertial measurement units at 100 Hz of sample rate. Data were extracted from intensities of the GXT when lactate thresholds (LT1, LT2) and peak power (POpeak) were determined. Results showed that only Pelvic Angle ( p < 0.01, d > 1.15) and Pelvic Rotation ( p < 0.01, d > 1.37) were sensitive to increases in exercise intensity (i.e. greater inclination and increased rotation at greater power). Multivariate liner regression analyses showed that a reduced range of movement (ROM) for the upper legs at sub-maximum intensities (LT1 and LT2) was associated with greater power production ( r2 > 0.21), whilst a reduced ROM for the right foot was associated with greater POpeak ( r2 = 0.20). In conclusion, changes in movement patterns were limited to a greater inclination and rotation of the pelvis at maximum power without changes in other MPIs throughout the GXT. Cyclists who produced greater power presented less ROM for their upper legs at LT1 and LT2 whilst at POpeak and greater power production was moderately associated with less ROM for the right foot. Coaches may be able to use MPI to analyze for excess ROM, particularly at higher exercise intensities, as this seems to increase inefficiencies and limit power production.

The Tyme Wear Smart Shirt is Reliable and Valid at Detecting Personalized Ventilatory Thresholds in Recreationally Active Individuals

The aim of this study was to determine the extent to which the Tyme Wear smart shirt is as reliable and valid in detecting personalized ventilatory thresholds when compared to the Parvo Medics TrueOne 2400. In this validation study, 19 subjects were recruited to conduct two graded exercise test (GXT) trials. Each GXT trial was separated by seven to ten days of rest. During the GXT, gas exchange and heart rate data were collected by the TrueOne 2400 (TRUE) in addition to the ventilation data collected by the Tyme Wear smart shirt (S-PRED). Gas exchange data from TRUE was used to detect VT1 and VT2. TRUE and S-PRED VT1 and VT2 were compared to determine the reliability and validity of the smart shirt. Of the 19 subjects, data from 15 subjects were used during analysis. S-PRED exhibited excellent (ICC &amp;gt; 0.90) reliability for detection of VT1 and VT2 utilizing time point and workload and moderate (0.90 &amp;gt; ICC &amp;gt; 0.75 ) reliability utilizing heart rate. TRUE exhibited excellent reliability for detection of VT1 and VT2 utilizing time point, workload, and heart rate. When compared to TRUE, S-PRED appears to underestimate the VT1 workload (p &amp;gt; 0.05) across both trials and heart rate (p &amp;lt; 0.05) for trial 1. However, S-PRED appears to underestimate VT2 workload (p &amp;lt; 0.05) and heart rate (p &amp;lt; 0.05) across both trials. The result from this study suggests that the Tyme Wear smart shirt is less valid but is comparable in reliability when compared to the gold standard. Moreover, despite the underestimation of S-PRED VT1 and VT2, the S-PRED detected personalized ventilatory thresholds will provide an adequate training workload for most individuals. In conclusion, the Tyme Wear smart shirt provides easily accessible testing to establish threshold-guided training zones but does not devalue the long-standing laboratory equivalent.

Validity and reliability of a clinical non-exercise method for assessment of cardiorespiratory fitness using seismocardiography

Introduction Low cardiorespiratory fitness expressed as a low maximal oxygen consumption (V̇O2max) is associated with cardiovascular disease and all-cause mortality (1). Thus, V̇O2max is recognised as an important clinical tool in the assessment of patients (1,2). However, assessment of V̇O2max by exercise testing is both physically demanding and methodologically challenging and hence the clinical applicability is limited. Purpose Therefore, the aim of this study was to investigate the accuracy and precision of a clinical non-exercise method for assessment of V̇O2max. Methods On three separate days 20 healthy men (n=10) and women (n=10) with varying age (22–72 years) and fitness levels performed two tests for determination of V̇O2max; (a) a non-exercise test using seismocardiography (SCG V̇O2max) and (b) a graded exercise test to voluntary exhaustion on a cycle ergometer based on indirect calorimetry (IC V̇O2max). These tests were performed in order to examine the day-to-day reliability and the validity of SCG V̇O2max, respectively. Furthermore, SCG V̇O2max was assessed twice on each test day to investigate test-retest reliability. The SCG V̇O2max was performed in prone position following a short resting period by placing the SCG recording device on the xiphisternal joint with double adhesive tape. V̇O2max was assessed during a 5-minute recording of the sternal movement using SCG in combination with demographic data of the participants (3). In addition, body composition was measured and a resting blood sample collected each test day. Results On average SCG V̇O2max was 3.3±2.4 ml/min/kg (mean ± 95% CI) lower than IC V̇O2max (p=0.013, SCG V̇O2max: 36.6±3.3 ml/min/kg, IC V̇O2max: 39.9±3.0 ml/min/kg). A significant positive correlation was found between SCG V̇O2max and IC V̇O2max (Pearson, r=0.72, p&lt;0.001). Both SCG V̇O2max and IC V̇O2max was similar between test days (p=0.972) and the intra-individual coefficient of variation was 4.5±2.9% and 4.0±2.5%, respectively. Within each test day SCG V̇O2max was highly correlated (r=0.99, p&lt;0.0001) and no difference was observed between tests (p=0.993). Conclusions The accuracy of the current non-exercise assessment of cardiorespiratory fitness based on seismocardiography is not optimal as SCG V̇O2max was systematically lower than the gold standard assessment applying indirect calorimetry during a graded exercise test. Despite the abovementioned difference, SCG V̇O2max and IC V̇O2max were highly correlated. Furthermore, the precision of SCG V̇O2max is very high as both day-to-day and test-retest reliability were high. FUNDunding Acknowledgement Type of funding sources: Private company. Main funding source(s): VentriJect ApS, Copenhagen, Denmark

Effect of Different Types of Face Masks on the Ventilatory and Cardiovascular Response to Maximal-Intensity Exercise

The development of new models of face masks makes it necessary to compare their impact on exercise. Therefore, the aim of this work was to compare the cardiopulmonary response to a maximal incremental test, perceived ventilation, exertion, and comfort using FFP2 or Emotion masks in young female athletes. Thirteen healthy sportswomen (22.08 ± 1.75 years) performed a spirometry, and a graded exercise test on a treadmill, with a JAEGER® Vyntus CPX gas analyzer using an ergospirometry mask (ErgoMask) or wearing the FFP2 or the Emotion mask below the ErgoMask, randomized on 3 consecutive days. Also, menstrual cycle status was monitored to avoid possible intrasubject alterations. The results showed lower values for the ErgoMask+FFP2, compared to ErgoMask or ErgoMask+Emotion, in forced vital capacity (3.8 ± 0.2, 4.5 ± 0.2 and 4.1 ± 0.1 l, respectively); forced expiratory volume in 1 s (3.3 ± 0.2, 3.7 ± 0.2 and 3.5 ± 0.1 l); ventilation (40.9 ± 1.5, 50.6 ± 1.5 and 46.9 ± 1.2 l/min); breathing frequency (32.7 ± 1.1, 37.4 ± 1.1 and 35.3 ± 1.4 bpm); VE/VO2 (30.5 ± 0.7, 34.6 ± 0.9 and 33.6 ± 0.7); VE/VCO2 (32.2 ± 0.6, 36.2 ± 0.9 and 34.4 ± 0.7) and time to exhaustion (492.4 ± 9.7, 521.7 ± 8.6 and 520.1 ± 9.5 s) and higher values in inspiratory time (0.99 ± 0.04, 0.82 ± 0.03 and 0.88 ± 0.03 s).. In conclusion, in young healthy female athletes, the Emotion showed better preservation of cardiopulmonary responses than the FFP2.

Respiratory Activity during Exercise: A Feasibility Study on Transition Point Estimation Using Impedance Pneumography

The current diagnostic procedures for assessing physiological response to exercise comprise blood lactates measurements, ergospirometry, and electrocardiography. The first is not continuous, the second requires specialized equipment distorting natural breathing, and the last is indirect. Therefore, we decided to perform the feasibility study with impedance pneumography as an alternative technique. We attempted to determine points in respiratory-related signals, acquired during stress test conditions, that suggest a transition similar to the gas exchange threshold. In addition, we analyzed whether or not respiratory activity reaches steady states during graded exercise. Forty-four students (35 females), practicing sports on different levels, performed a graded exercise test until exhaustion on cycloergometer. Eventually, the results from 34 of them were used. The data were acquired with Pneumonitor 2. The signals demonstrated that the steady state phenomenon is not as evident as for heart rate. The results indicated respiratory rate approaches show the transition point at the earliest (more than 6 min before the end of the exercise test on average), and the tidal volume ones at the latest (less than 5 min). A combination gave intermediate findings. The results showed the impedance pneumography appears reasonable for the transition point estimation, but this should be further studied with the reference.