scholarly journals Multiple severe late adverse effects after definitive chemoradiation for locally advanced cervical cancer

2021 ◽  
Author(s):  
Calida Marie Danko ◽  
Linda Jahwa Hong ◽  
Jerry Donald Slater
Keyword(s):  
Cervical Cancer ◽  
Adverse Effects ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation ◽  
Late Adverse Effects

Impact of pretreatment P53 gene mutation in locally advanced cervical cancer patients treated with definitive chemoradiation on treatment outcomes.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e16506-e16506
Author(s):  
Prarthana Dalal ◽  
Tamer Refaat ◽  
Eric Donald Donnelly ◽  
Sean Sachdev ◽  
Vamsi Parimi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Treatment Outcomes ◽  
Cancer Patients ◽  
Gene Mutation ◽  
Locally Advanced ◽  
P53 Gene ◽  
Advanced Cervical Cancer ◽  
P53 Gene Mutation ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation

Predicting the necessity of adding catheters to intracavitary brachytherapy for women undergoing definitive chemoradiation for locally advanced cervical cancer

Brachytherapy ◽  
2018 ◽  
Vol 17 (6) ◽  
pp. 935-943 ◽  
Author(s):  
Daniel Moore Freitas Palhares ◽  
Daniel Grossi Marconi ◽  
Tatiana Leitão de Azevedo ◽  
Clayton Burnett Hess ◽  
José Humberto Tavares Guerreiro Fregnani ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Locally Advanced ◽  
Intracavitary Brachytherapy ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation

scholarly journals Control of PET-Positive Lymph Nodes Treated with Definitive Chemoradiation in Locally Advanced Cervical Cancer

2018 ◽  
Vol 102 (3) ◽  
pp. e622-e623
Author(s):  
R.W. Gao ◽  
C.R. Shideman ◽  
D.C. Mathew ◽  
K.E. Dusenbery ◽  
M.A. Reynolds ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Nodes ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation ◽  
Positive Lymph Nodes

Predictors of Radiation Field Failure After Definitive Chemoradiation in Patients With Locally Advanced Cervical Cancer

2016 ◽  
Vol 26 (4) ◽  
pp. 737-742 ◽  
Author(s):  
Hyo Sook Bae ◽  
Yeon-Joo Kim ◽  
Myong Cheol Lim ◽  
Sang-Soo Seo ◽  
Sang-yoon Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Tumor Size ◽  
Risk Group ◽  
Locally Advanced ◽  
High Risk Group ◽  
Advanced Cervical Cancer ◽  
Locoregional Failure ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation

PurposeWe identified the predictive factors for locoregional failure after definitive chemoradiation in patients with locally advanced cervical cancer.MethodsAltogether, 397 patients with locally advanced cervical cancer (stage IB2–IVA) were treated with definitive chemoradiation between June 2001 and February 2010. Platinum-based concurrent chemotherapy was given to all patients with median radiation dose of external beam radiotherapy 50.4 Gy in 28 fractions and intracavitary radiotherapy 30 Gy in 6 fractions. Competing risk regression analysis was used to reveal the predictive factors for locoregional failure.ResultsDuring the median follow-up of 7.2 years, locoregional failure occurred in 51 (12.9%) patients. The estimated 3-year rate of locoregional control was 89%, whereas the overall survival rate was 82%. After univariate and multivariate analyses, large tumor size (>5 cm), young age (≤40 years), nonsquamous histology, positive lymph node on magnetic resonance imaging, and advanced stage (III–IV) were identified as risk factors for locoregional failure (P = 0.003, P = 0.075, P = 0.005, P = 0.055, and P < 0.001, respectively). After risk grouping according to the coefficients from the multivariate model, we identified a high-risk group for locoregional failure after treatment with definitive chemoradiation as follows: (1) tumor size larger than 5 cm, and at least 1 other risk factor or (2) tumor size 5 cm or less, and at least 3 other risk factors. The cumulated estimated 3-year rate of locoregional failure of the high-risk group was 26%, which was significantly higher than that of the low-risk group (7%, P < 0.001). The 3-year overall survival rates of the 2 groups were also significantly different (57% vs 86%, P < 0.001).ConclusionsLarge tumor size (>5 cm), young age (≤40 years), nonsquamous histology, positive lymph node on magnetic resonance imaging, and advanced stage are all risk factors for locoregional failure after definitive platinum-based chemoradiation in patients with locally advanced cervical cancer. In the high-risk group, further clinical trials are warranted to improve the locoregional control rate.

scholarly journals Long-term patient-reported distress in locally advanced cervical cancer patients treated with definitive chemoradiation

2020 ◽  
Vol 23 ◽  
pp. 1-8 ◽  
Author(s):  
Jessica L. Conway ◽  
Shira Felder ◽  
Jiayin Tang ◽  
Jelena Lukovic ◽  
Kathy Han ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation ◽  
Patient Reported

scholarly journals Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)

2020 ◽  
Vol 26 (21) ◽  
pp. 5621-5630
Author(s):  
Diane M. Da Silva ◽  
Danielle M. Enserro ◽  
Jyoti S. Mayadev ◽  
Joseph G. Skeate ◽  
Koji Matsuo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Immune Activation ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation

Predictors of radiation field failure after definitive chemoradiation in patients with locally advanced cervical cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e16518-e16518
Author(s):  
Hyo Sook Bae ◽  
Yeon-Joo Kim ◽  
Myong Cheol Lim ◽  
Sang-Soo Seo ◽  
Sang-Yoon Park ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radiation Field ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Definitive Chemoradiation ◽  
Field Failure
Sign in / Sign up

Export Citation Format

Share Document