Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model

The Prostate ◽  
2006 ◽  
Vol 67 (1) ◽  
pp. 83-106 ◽  
Author(s):  
Sharon D. Morgenbesser ◽  
Rajashree P. McLaren ◽  
Brenda Richards ◽  
Mindy Zhang ◽  
Viatcheslav R. Akmaev ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Metastatic Tumor ◽  
Genetically Engineered ◽  
Cancer Model ◽  
Mouse Prostate ◽  
Androgen Independent ◽  
Prostate Cancer Model

scholarly journals Molecular Targeted Enhanced Ultrasound Imaging of Flk1 Reveals Diagnosis and Prognosis Potential in a Genetically Engineered Mouse Prostate Cancer Model

2009 ◽  
Vol 8 (4) ◽  
pp. 7290.2009.00020 ◽  
Author(s):  
Jim W. Xuan ◽  
Michael Bygrave ◽  
Fatma Valiyeva ◽  
Madeleine Moussa ◽  
Jonathan I. Izawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ultrasound Imaging ◽  
Genetically Engineered ◽  
Cancer Model ◽  
Diagnosis And Prognosis ◽  
Mouse Prostate ◽  
Prostate Cancer Model

scholarly journals A Transgenic Mouse Prostate Cancer Model

1996 ◽  
Vol 24 (4) ◽  
pp. 502-504 ◽  
Author(s):  
J.R. Gingrich ◽  
N.M. Greenberg
Keyword(s):  
Prostate Cancer ◽  
Transgenic Mouse ◽  
Cancer Model ◽  
Mouse Prostate ◽  
Prostate Cancer Model

scholarly journals Therapeutic effects of adoptive splenocyte transfer following in situ AdIL-12 gene therapy in a mouse prostate cancer model

2005 ◽  
Vol 13 (1) ◽  
pp. 91-98 ◽  
Author(s):  
T Saika ◽  
N Kusaka ◽  
V Mouraviev ◽  
T Satoh ◽  
H Kumon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Therapeutic Effects ◽  
Cancer Model ◽  
Mouse Prostate ◽  
Prostate Cancer Model

scholarly journals Tumor-infiltrating Leukocytes Suppress Local Inflammation Via Interleukin-1 Receptor Antagonist in a Syngeneic Prostate Cancer Model

Biology ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 67 ◽  
Author(s):  
Yu-Ching Fan ◽  
Wei-Yu Chen ◽  
Kuan-Der Lee ◽  
Yuan-Chin Tsai
Keyword(s):  
Prostate Cancer ◽  
Tumor Microenvironment ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Cancer Model ◽  
Interleukin 1 Receptor Antagonist ◽  
Mouse Prostate ◽  
Inflammatory Chemokines ◽  
Anti Inflammatory ◽  
Prostate Cancer Model

Background: Several lines of evidence have demonstrated the tumor-promoting function of inflammation. Since many chemokines are important in coordinating immune cells during inflammation, monitoring intratumoral chemokines provides a way to study the tumor microenvironment. Methods: To identify tumorigenic chemokines, we compared two syngeneic mouse prostate cancer cell lines by an antibody array and quantitative reverse-transcription polymerase chain reaction (RT-PCR). The tumor microenvironment was analyzed by monitoring gene expressions in mouse tumor tissues, primary cells, and tumor-infiltrating leukocytes (TILs). Result: We identified a group of pro-inflammatory chemokines associated with a tumorigenic transgenic adenocarcinoma mouse prostate (TRAMP)-C1 cell line. In the tumor microenvironment, the TILs secrete a natural anti-inflammatory factor, interleukin-1 receptor antagonist (IL1RN), which inhibits the functions of pro-inflammatory molecules and likely accounts for tumor type-specific anti-inflammation functions. Conclusion: Our results support that tumor cells recruit TILs by pro-inflammatory chemokines to establish an IL1RN-mediated anti-inflammatory environment in the syngeneic prostate cancer model.

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