Does the digital finance revolution validate the Environmental Kuznets Curve? Empirical findings from China

In recent years, digital finance has become a crucial part of the financial system and reshaped the mode of green finance in China. Digital finance has brought certain impact on economic growth, industrial structure, and resident income, which may affect pollution. The nexus of digital finance and environment in China is thus worth exploring. By revising the traditional Environmental Kuznets Curve model with income inequality variable, this paper decomposes the environmental effects of economic activities into income growth effect, industrial structure effect and income inequality effect, and use panel data of China’s provinces to conduct an empirical analysis. The results reveal the following: (1) the Environmental Kuznets Curve is still valid in sample, and digital finance can reduce air and water pollution (as measured through SO2 and COD emission) directly; (2) in the influence mechanism, digital finance can alleviate income inequality and promote green industrial structure, thus reducing pollution indirectly, but the scale effect of income growth outweighs the technological effect, which increases pollution indirectly; and (3) digital finance has a threshold effect on improving the environment, then an acceleration effect appears after a certain threshold value. From the regional perspective, digital finance development in eastern regions is generally ahead of central and western regions, and the effects of environmental improvement in the eastern regions are greater. According to the study, this paper suggest that digital finance can be an effective way to promote social sustainability by alleviating income inequality and environmental sustainability by reducing pollution.

Effect of domestic greywater reuse for irrigation on soil physical and chemical characteristics and tomatoes growth.

This study aimed at determining the effect of laundry greywater on the growth of tomatoes and physical and chemical properties of a sandy loam Perrox in the Eastern province of Rwanda, Kayonza district, Mwiri sector. The experimental design consisted of plots planted with tomatoes (Lepersicon Esculantum) in a randomized complete block design with three replications and four treatments. Treatment 1: Tomatoes irrigated with pure greywater; Treatment 2: Tomatoes irrigated with a mixture of tap water and greywater at 1:1 ratio; Treatment 3: Alternation of greywater and tap water in a consecutive manner; and Treatment 4: only tap water serving as a control. Results showed that the following soil chemical parameters were significantly increased with greywater application: pH, EC, Av P, Na and SAR. Conversely, soil concentration in Mg and Ca significantly decreased with increase in greywater application. With the exception of soil bulk density, other measured physical properties such as soil hydraulic conductivity, aggregate stability and porosity were significantly reduced with greywater application. The highest values for soil hydraulic conductivity, aggregate stability and porosity were found for soil irrigated with tap water which ranged between 1.01 to 2.1 times higher than that of greywater, mixed or alternated with tap water. The alternate application of greywater and tap water did not affect significantly the stem height and weight of tomatoes. We concluded that the absence of positive growth effect of application of greywater was due to low concentration in essential plant nutrients in greywater, and induced adverse effects on soil chemical, physical, and biological properties. However, alternate application of the greywater and tap water preserved approximately the same soil physico-chemical characteristics as with application of tap water. Thus, among the irrigation treatments involving greywater, the latter should be considered as the most environmentally friendly. We propose combination of greywater with various forms of composts as the one of the most promising investigations on the reuse of greywater in irrigation.

Scutellaria Barbata D.Don (SBD) Extracts Suppressed Tumor Growth, Metastasis and Angiogenesis in Prostate Cancer Via PI3K/Akt Pathway

Background: Scutellaria barbata D.Don (SBD) is derived from the dried whole plant of Labiate that has been widely used to treat patients with multiple cancer. It was previously reported that the ethanol extract of SBD is able to promote apoptosis, and inhibit cell proliferation and angiogenesis in cancer.Materials and methods: CCK8, Edu assays and colony formation assay were performed to assess the effect of SBD on PCa cell growth. Effect of SBD on apoptosis and cell cycle was detected by flow cytometry. Transwell and wounding healing assay were performed to detected the invasion and migration activities of PCa cells. Western blot was employed to detect the protein expression. 2RRV1 mouse xenograft model was established to detect the effect of SBD on prostate cancer. Angiogenesis was analysed by coculturing PCa cell lines and HUVECs.Results: The results showed that SBD induced a significant decrease in cell viability and clonogenic growth in a dose-dependent manner. SBD induced cell apoptosis and cell cycle G2/M phase arrest by inactivating PI3K/AKT signalling pathway. Treatment with SBE also significantly decreased the cell migration and invasion via phenotypic inversion of EMT that was characterized by the increased expression of E-cadherin and Vimentin, and decreased expression of N-cadherin, which could be partially attributed to inhibiting PI3K/AKT signalling pathway. Subsequently, using AKT inhibitor MK2206, we performed that PI3K/AKT are also involved in cell apoptosis and metastasis of PCa cells stimulated by SBE. In addition, to its direct effects on PCa cells, SBD also exhibited anti-angiogenic properties. SBD alone or conditioned media from SBD-treated PCa cells inhibited HUVEC tube formation on Matrigel without affecting HUVEC viability. Furthermore, 22RV1 xenograft C57BL/6 mice treated with SBE in vivo showed a significant decrease in tumour size and tumour weight without toxicity. In addition, administration with medium- or high-dose of SBE significantly inhibited the cell proliferation and promoted the damage of tumour tissues.Conclusions: Collectively, our in vitro and in vivo findings suggest that SBE had the potential to develop into a safe and potent alternative therapy for PCa patients.

Anti-Staphylococcus aureus Methicillin-Resistant (MRSA) Activity of a Novel 3-Chalcogenyl Indole

Objective: the development of new drugs against Methicillin-resistant Staphylococcus aureus is a priority to the World Health Organization. So, the objective of this study was to evaluate the antibacterial activity and toxicity of 5-bromo-3-((4-methoxyphenyl) sulfenyl)-1H-indole (3b) against MRSA.Methods: minimum inhibitory concentration (MIC) of 3b was determined against S. aureus ATCC 29213 and 43 clinical isolates. The time-kill assay was performed for 9 isolates. Analysis of variance followed by the post hoc Bonferroni test was used for the statistical tests.Results and conclusions: the MIC50 and MIC90 of 3b were 4 μg.mL-1 and 16 μg.mL-1 respectively. In time-kill assay, the 3b showed bactericidal activity to all evaluated isolates at concentrations of 1xMIC and 2xMIC and the re-growth effect was not observed. About the toxicity tests, 3b has not presented cytotoxicity, mutagenicity, or allergenicity. 3b had particularly good activity against MRSA demonstrating high potential for the development of new antimicrobials products.

Threshold Effects of Import Dependence on Economic Growth in Nigeria

This study uses annual time series data spanning 1981–2018 to investigate the threshold effects of import dependence on economic growth in Nigeria. The ordinary least squares (OLS) and the fully modified OLS (FMOLS) techniques are employed for estimation of a quadratic regression model to determine the nature of the relationship between aggregate import dependence and economic growth. It is found that the relationship is concave, that is, it follows an inverted-U shape. The conditional least squares estimator is thereafter employed to estimate the threshold model specified to determine the threshold level of import dependence. The study finds a threshold level of 26% for aggregate import dependence. Below this threshold, import dependence positively affects economic growth; above the threshold, the growth effect of import dependence is adverse. Furthermore, it is found that the long-run growth effect of Inflation is adverse, and investment is favourable to long-run economic growth. Based on these findings, the paper recommends efforts by Nigeria’s government to reduce import dependence below the estimated threshold of 26%, control inflation and encourage investment so as to enhance the growth of the nation’s economy.

Growth Effect of the Different Ratios of Wood Vinegar on Brassica juncea

Four (4) different ratios of wood vinegar namely; 1:5; 1:10; 1:20 and 1:30 mL WV to water ratio extracted from coconut shell was tested to determine their growth effect on Brassica juncea or mustard plant or locally known as mustasa. Parameters measured were leaf number, plant height, plant leaf width. Using randomized complete block design, experimental tests were conducted using Brassica juncea as test plants. The samples of 10 days old were allowed to flourish in a potted plant with day to day application of the wood vinegar solutions together with the negative control for a total of 30 days. Results revealed that the wood vinegar ratios applied have no significant effect on the growth of the mustard plant in terms of its leaf number, plant height and leaf width. This indicates that coconut shell wood vinegar at 1:5, 1:10, 1:20 and 1:30 are not applicable ratios for plant production, as that an increased wood vinegar application increases plant production and growth.

Potential of Bacterial Strains Isolated from Coastal Water for Wastewater Treatment and as Aqua-Feed Additives

Bacteria have various and sustained effects on humans in various fields: molecular biology, biomedical science, environmental/food industry, etc. This study was conducted to evaluate the wastewater treatment capacity and feed-additive fish-growth effect of four strains of bacteria: Pseudoalteromonas mariniglutinosa, Psychrobacter celer, Bacillus albus, and Bacillus safensis. In a wastewater degradation experiment, (i) nitrate-N and nitrite-N were removed within 1 h in all of the 4 bacterial strains; (ii) the removal rates of TAN and TN were higher in all of the strains relative to the B. subtilis. In a feed-additive experiment (5% Kg−1), (i) the growth of fish was higher in all of the 4 bacterial strains with the B. subtilis relative to the commercial feed; (ii) there was no significant growth difference for B. albus and B. safensis relative to the B. subtilis, but growth was higher in P. mariniglutinosa and P. celer. The results indicated that the 4 bacterial strains can be effectively utilized for biological wastewater treatment processes and as aqua-feed.

Baldwin versus Cecchini revisited: the growth impact of the European Single Market

The European Single Market created a common market for millions of Europeans. However, 30 years after its introduction, it appears that the benefits of the common European project are occasionally being questioned at least by some parts of the population. Others, by contrast, strive for deeper integration. Against this background, we empirically gauge the growth effect that arose from the Single Market. Using the synthetic control method, we establish the growth premium for the Single Market overall and for its founding members. Broadly in line with the predictions made by Richard Baldwin at the onset of the Single Market project, we find significantly higher real GDP per capita for the overall Single Market area of around 12–22 %. In comparison, smaller EU Member States seem to have benefited somewhat more compared to larger countries. The estimated growth effects underline the case for further deepening and broadening the Single Market where possible.

An Empirical Study of Carbon Emission Impact Factors Based on the Vector Autoregression Model

It is important to effectively reduce carbon emissions and ensure the simultaneous adjustment of economic development and environmental protection. Therefore, we used Kaya identity to screen the factors influencing carbon emissions and conducted preliminary qualitative analyses, including grey relation analysis and linear regression analysis, on important variables to establish a vector autoregression (VAR) model based on their annual data to empirically analyze the influencing factors of carbon emissions. The results showed that economic growth effect, energy intensity effect and embodied carbon in foreign trade were the key factors affecting carbon emissions, among which the economic growth effect contributed the most. Accordingly, we propose countermeasures including technological innovation to reduce energy intensity, the development of new energy sources to improve energy structure, acceleration of industrial structure transfer, and optimization of trade structure.

Role of a Putative Cyclic Di-GMP Forming Locus MSMEG_2196 in Mycobacterium Smegmatis

<p>Cyclic di-guanosine-monophosphate (c-di-GMP) has been recognized as a second messenger in bacteria controlling multiple cellular processes such as biofilm formation, motility, and virulence. Proteins containing GGDEF and EAL domains are engaged in the synthesis and degradation, respectively, of cyclic di-GMP. Some bacteria contain multiple proteins with GGDEF and EAL domains. The genome of Mycobacterium tuberculosis encodes only one protein (Rv1354c) which contains a GGDEF domain. This protein also contains a tandem EAL. The function of this protein in mycobacteria has not yet been determined. In this study, the orthologue of Rv1354c was investigated in Mycobacterium smegmatis (MSMEG_2196). The expression of MSMEG_2196 in M. smegmatis was altered by constructing sense and antisense expressing strains. The effect of the altered expression of MSMEG_2196 on M. smegmatis was tested under carbon, oxygen, phosphorous, and nitrogen limited growth conditions. There was no significant effect on growth in either the antisense or sense expressing strains grown under nutrient-rich, or carbon-, or oxygen-, or phosphorous limitation conditions. However, a growth effect was observed in the antisense expressing strain when grown under nitrogen-limited conditions. In particular, at mid stationary-phase (1,800 min) the MSMEG_2196 antisense strain had an OD600 value of 0.60, compared to that of the control M. smegmatis/pMind strain (OD600 value of 1.09). These results were further confirmed by the low colony forming units measures observed in MSMEG_2196 antisense strain. Proteomic analysis was carried out on the MSMEG_2196 antisesne expressing strain grown in the nitrogen-limited condition. Proteins that were differentially expressed were identified by mass spectrometry. A number of the proteins that were down-regulated in the antisense expressing strain are important in the survival of the bacteria under nitrogen-limited conditions. This study indicates a role for MSMEG_2196 in growth or survival of mycobacteria under nitrogen-limitations.</p>