Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorfi on rat uterus in vitro

2003 ◽  
Vol 17 (4) ◽  
pp. 320-324 ◽  
Author(s):  
K. M. de Alencar Cunha ◽  
L. A. F. Paiva ◽  
F. A. Santos ◽  
N. V. Gramosa ◽  
E. R. Silveira ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Rat Uterus ◽  
Relaxant Effect ◽  
Kaurenoic Acid ◽  
Smooth Muscle Relaxant

scholarly journals Human Meconium Has a Pulmonary Vascular and Airway Smooth Muscle Relaxant Effect

2008 ◽  
Vol 64 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Rogerio Tessler ◽  
Jingyi Pan ◽  
Humberto Holmer Fiori ◽  
Jaques Belik
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Relaxant ◽  
Relaxant Effect ◽  
Smooth Muscle Relaxant

scholarly journals Triterpenoids, Including One with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Asmita V. Patel ◽  
Gerald Blunden
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Column Chromatography ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Guinea Pig Ileum ◽  
Muscle Relaxant Activity ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves was fractionated by column chromatography and the eluted samples were tested for their ability to relax transmurally stimulated Guinea pig ileum preparations in vitro. Two distinct bands of activity were detected. From band one sitosterol and eight triterpenoids were characterized, but only olean-18-ene-1β, 2α, 3α-triol demonstrated smooth muscle relaxant activity. This compound is, to the best of our knowledge, novel, as are olean-12-ene-3β, 29-diol and urs-12-ene-3β, 30-diol.

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