scholarly journals The smooth muscle relaxant effect of hydrogen sulphide in vitro : evidence for a physiological role to control intestinal contractility

2002 ◽  
Vol 137 (2) ◽  
pp. 139-145 ◽  
Author(s):  
B Teague ◽  
S Asiedu ◽  
P K Moore
Keyword(s):  
Smooth Muscle ◽  
Hydrogen Sulphide ◽  
Muscle Relaxant ◽  
Physiological Role ◽  
Relaxant Effect ◽  
Smooth Muscle Relaxant

Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorfi on rat uterus in vitro

2003 ◽  
Vol 17 (4) ◽  
pp. 320-324 ◽  
Author(s):  
K. M. de Alencar Cunha ◽  
L. A. F. Paiva ◽  
F. A. Santos ◽  
N. V. Gramosa ◽  
E. R. Silveira ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Rat Uterus ◽  
Relaxant Effect ◽  
Kaurenoic Acid ◽  
Smooth Muscle Relaxant

scholarly journals Human Meconium Has a Pulmonary Vascular and Airway Smooth Muscle Relaxant Effect

2008 ◽  
Vol 64 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Rogerio Tessler ◽  
Jingyi Pan ◽  
Humberto Holmer Fiori ◽  
Jaques Belik
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Relaxant ◽  
Relaxant Effect ◽  
Smooth Muscle Relaxant

scholarly journals Triterpenoids, Including One with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Asmita V. Patel ◽  
Gerald Blunden
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Column Chromatography ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Guinea Pig Ileum ◽  
Muscle Relaxant Activity ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves was fractionated by column chromatography and the eluted samples were tested for their ability to relax transmurally stimulated Guinea pig ileum preparations in vitro. Two distinct bands of activity were detected. From band one sitosterol and eight triterpenoids were characterized, but only olean-18-ene-1β, 2α, 3α-triol demonstrated smooth muscle relaxant activity. This compound is, to the best of our knowledge, novel, as are olean-12-ene-3β, 29-diol and urs-12-ene-3β, 30-diol.

scholarly journals Smooth Muscle Relaxant Triterpenoid Glycosides from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (9) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Gerald Blunden ◽  
Asmita V. Patel
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Spectrometric Data ◽  
Triterpenoid Glycosides ◽  
Muscle Relaxant Activity ◽  
Tlc Separation ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves had a relaxant activity on transmurally stimulated Guinea pig ileum preparations in vitro. The extract, when fractionated by column chromatography, yielded two distinct bands with pharmacological activity. After extensive column and preparative TLC separation, several compounds with smooth muscle relaxant properties were obtained. From band two, three triterpenoid glycosides were characterized, which had significant muscle relaxant activity. From spectroscopic and spectrometric data, these were identified as 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-triol (TG1); 28-(O-β-D-glucopyranosyl)-urs-12-ene-2α, 3β, 19α-trihydroxy-28-oic acid (TG2); and 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-trihydroxy-28-oic acid (TG3). To the best of our knowledge, TG1 and TG3 are novel compounds.

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