Chinese medicine Banxia-houpu decoction regulates c-fos expression in the brain regions in chronic mild stress model in rats

2004 ◽  
Vol 18 (3) ◽  
pp. 200-203 ◽  
Author(s):  
Weiyun Zhang ◽  
Jianmei Li ◽  
Jixiao Zhu ◽  
Zhenqiu Shi ◽  
Yong Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Chronic Mild Stress ◽  
Brain Regions ◽  
Mild Stress ◽  
Stress Model ◽  
Fos Expression ◽  
The Brain

scholarly journals Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning

2017 ◽  
Vol 51 (2) ◽  
pp. 73-83
Author(s):  
J. Osacka ◽  
L. Horvathova ◽  
Z. Majercikova ◽  
Alexander Kiss
Keyword(s):  
Area Postrema ◽  
Chronic Mild Stress ◽  
Brain Structures ◽  
Ventrolateral Medulla ◽  
Mild Stress ◽  
Fos Protein ◽  
Male Wistar Rats ◽  
Fos Expression ◽  
Central Gray ◽  
The Brain

AbstractObjective. Fos protein expression in catecholamine-synthesizing neurons of the substantia nigra (SN) pars compacta (SNC, A8), pars reticulata (SNR, A9), and pars lateralis (SNL), the ventral tegmental area (VTA, A10), the locus coeruleus (LC, A6) and subcoeruleus (sLC), the ventrolateral pons (PON-A5), the nucleus of the solitary tract (NTS-A2), the area postrema (AP), and the ventrolateral medulla (VLM-A1) was quantitatively evaluated aft er a single administration of asenapine (ASE) (designated for schizophrenia treatment) in male Wistar rats preconditioned with a chronic unpredictable variable mild stress (CMS) for 21 days. Th e aim of the present study was to reveal whether a single ASE treatment may 1) activate Fos expression in the brain areas selected; 2) activate tyrosine hydroxylase (TH)-synthesizing cells displaying Fos presence; and 3) be modulated by CMS preconditioning.Methods. Control (CON), ASE, CMS, and CMS+ASE groups were used. CMS included restraint, social isolation, crowding, swimming, and cold. Th e ASE and CMS+ASE groups received a single dose of ASE (0.3 mg/kg, s.c.) and CON and CMS saline (300 μl/rat, s.c.). The animals were sacrificed 90 min aft er the treatments. Fos protein and TH-labeled immunoreactive perikarya were analyzed on double labeled histological sections and enumerated on captured pictures using combined light and fluorescence microscope illumination.Results. Saline or CMS alone did not promote Fos expression in any of the structures investigated. ASE alone or in combination with CMS elicited Fos expression in two parts of the SN (SNC, SNR) and the VTA. Aside from some cells in the central gray tegmental nuclei adjacent to LC, where a small number of Fos profiles occurred, none or negligible Fos occurrence was detected in the other structures investigated including the LC and sLC, PON-A5, NTS-A2, AP, and VLM-A1. CMS preconditioning did not infl uence the level of Fos induction in the SN and VTA elicited by ASE administration. Similarly, the ratio between the amount of free Fos and Fos colocalized with TH was not aff ected by stress preconditioning in the SNC, SNR, and the VTA.Conclusions. Th e present study provides an anatomical/functional knowledge about the nature of the acute ASE treatment on the catecholamine-synthesizing neurons activity in certain brain structures and their missing interplay with the CMS preconditioning.

scholarly journals Synergistic Effect of Several Neurotransmitters in PFC-NAc-VTA Neural Circuit for the Anti-Depression Effect of Shuganheweitang in a Chronic Unpredictable Mild Stress Model

2021 ◽  
Vol 16 (3) ◽  
pp. 1934578X2110024
Author(s):  
Xin Chen ◽  
Yuanchun Ma ◽  
Xiongjun Mou ◽  
Hao Liu ◽  
Hao Ming ◽  
...  
Keyword(s):  
Animal Behavior ◽  
Neural Circuit ◽  
Concentration Level ◽  
Brain Regions ◽  
Mild Stress ◽  
Depression Effect ◽  
Monoamine Neurotransmitters ◽  
Reward Circuitry ◽  
High Doses ◽  
The Brain

Depression, a major worldwide mental disorder, leads to massive disability and can result in death. The PFC-NAc-VTA neuro circuit is related to emotional, neurovegetative, and cognitive functions, which emerge as a circuit-level framework for understanding reward deficits in depression. Neurotransmitters, which are widely distributed in different brain regions, are important detected targets for the evaluation of depression. Shuganheweitang (SGHWT) is a popular prescription in clinical therapy for depression. In order to investigate its possible pharmacodynamics and anti-depressive mechanism, the complex plant material was separated into different fractions. These in low and high doses, along with low and high doses of SGHWT were tested in animal behavior tests. The low and high doses of SGHWT were more effective than the various fractions, which indicate the importance of synergistic function in traditional Chinese medicine. Furthermore, amino acid (GABA, Glu) and monoamine neurotransmitters (DA, 5-HT, NA, 5-HIAA) in the PFC-NAc-VTA neuro circuit were investigated by UPLC-MS/MS. The level trend of DA and 5-HT were consistent in the PFC-NAc-VTA neuro circuit, whereas 5-HIAA was decreased in the PFC, Glu was decreased in the PFC and VTA, and NA and GABA were decreased in the NAc. The results indicate that the pathogenesis of depression is associated with dysfunction of the PFC-NAc-VTA neural circuit, mainly through the neural projection effects of neurotransmitters associated with various brain regions in the neural circuit. PCA and OPLS-DA score plots demonstrated the similarities of individuals within each group and the differences among the groups. In this study, SGHWT could regulate the concentration level of different neurotransmitters in the PFC-NAc-VTA neuro circuit to improve the depression, which benefitted from the recognition of the brain reward circuitry in mood disorders.

Desipramine increased experimental lung tumor growth in stress-sensitive rats in the chronic mild stress model of depression

2010 ◽  
Vol 62 ◽  
pp. 50
Author(s):  
Marta Kubera ◽  
Beata Grygier ◽  
Danuta Wrona ◽  
Piotr Gruca ◽  
Zofia Rogóz ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Tumor ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

scholarly journals Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism

2012 ◽  
Vol 4 (4) ◽  
pp. 627-632 ◽  
Author(s):  
JING-MEI ZHONG ◽  
SHAO-YUAN WU ◽  
JIE BAI ◽  
QIANG GUO ◽  
JIAN TAO ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Stress Model

Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

2019 ◽  
Vol 356 ◽  
pp. 156-169 ◽  
Author(s):  
Katayoun Sedaghat ◽  
Zahra Yousefian ◽  
Abbas Ali Vafaei ◽  
Ali Rashidy-Pour ◽  
Houman Parsaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression

2017 ◽  
Vol 134 ◽  
pp. 211-219 ◽  
Author(s):  
Ying Ren ◽  
Jin-Liang Wang ◽  
Xiang Zhang ◽  
Hao Wang ◽  
Ying Ye ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

Exploring the astrocytic neuroprotective functions in a chronic mild stress model of depression

2017 ◽  
Vol 27 ◽  
pp. S31-S32
Author(s):  
J.S. Correia ◽  
P. Patrício ◽  
N.D. Alves ◽  
A.R. Santos ◽  
M. Morais ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

scholarly journals Antidepressant-like effect of salidroside and curcumin on the immunoreactivity of rats subjected to a chronic mild stress model

2018 ◽  
Vol 121 ◽  
pp. 604-611 ◽  
Author(s):  
Liliya V. Vasileva ◽  
Kremena E. Saracheva ◽  
Mariya V. Ivanovska ◽  
Atanaska P. Petrova ◽  
Andrey S. Marchev ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

Novel antidepressant candidate RO-05 modulated glucocorticoid receptors activation and FKBP5 expression in chronic mild stress model in rats

Neuroscience ◽  
2015 ◽  
Vol 290 ◽  
pp. 255-265 ◽  
Author(s):  
Y. Xing ◽  
J. Hou ◽  
Q. Meng ◽  
M. Yang ◽  
H. Kurihara ◽  
...  
Keyword(s):  
Glucocorticoid Receptors ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

Poster #S22 THE ANTI-ANHEDONIC PROPERTIES OF LURASIDONE IN THE CHRONIC MILD STRESS MODEL ARE ASSOCIATED WITH SYNAPTIC AND NEUROPLASTIC CHANGES IN THE RAT PREFRONTAL CORTEX

2014 ◽  
Vol 153 ◽  
pp. S95-S96
Author(s):  
Marco A. Riva ◽  
Flavia Macchi ◽  
Andrea C. Rossetti ◽  
Mariusz Papp ◽  
Raffaella Molteni
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model
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