Standardized Aqueous Tribulus terristris (Nerunjil) Extract Attenuates Hyperalgesia in Experimentally Induced Diabetic Neuropathic Pain Model: Role of Oxidative Stress and Inflammatory Mediators

2012 ◽  
Vol 27 (11) ◽  
pp. 1646-1657 ◽  
Author(s):  
Ravichandran Ranjithkumar ◽  
S. Prathab Balaji ◽  
Bhaskar Balaji ◽  
R. V. Ramesh ◽  
Muthiah Ramanathan
Keyword(s):  
Oxidative Stress ◽  
Neuropathic Pain ◽  
Inflammatory Mediators ◽  
Diabetic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model ◽  
Experimentally Induced

Mechanisms of morphine-venlafaxine interaction in diabetic neuropathic pain model

2013 ◽  
Vol 65 ◽  
pp. 35
Author(s):  
Krystyna Cegielska-Perun ◽  
Agata Siwek ◽  
Małgorzata Dybała ◽  
Magdalena Bujalska-Zadrożny ◽  
Helena Makulska-Nowak
Keyword(s):  
Neuropathic Pain ◽  
Diabetic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals Modification of morphine analgesia by venlafaxine in diabetic neuropathic pain model

2012 ◽  
Vol 64 (5) ◽  
pp. 1267-1275 ◽  
Author(s):  
Krystyna Cegielska-Perun ◽  
Magdalena Bujalska-Zadrożny ◽  
Helena E. Makulska-Nowak
Keyword(s):  
Neuropathic Pain ◽  
Morphine Analgesia ◽  
Diabetic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

Modification of morphine analgesia by antidepressants in diabetic neuropathic pain model

2010 ◽  
Vol 62 ◽  
pp. 76
Author(s):  
Krystyna Cegielska-Perun ◽  
Magdalena Bujalska-Zadrożny ◽  
Małgorzata Dybała ◽  
Agata Siwek ◽  
Robert Wrzesień ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Morphine Analgesia ◽  
Diabetic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals Neuromidin Attenuates Neuropathic Pain in the Streptozocin-Induced Diabetes Model in Rats

2008 ◽  
Vol 62 (3) ◽  
pp. 85-90
Author(s):  
Vija Kluša ◽  
Juris Rumaks ◽  
Ñina Karajeva
Keyword(s):  
Neuropathic Pain ◽  
Diabetic Neuropathy ◽  
Diabetic Neuropathic Pain ◽  
Cholinergic Mechanism ◽  
Peripheral Neuropathic Pain ◽  
Pain Model ◽  
Diabetes Model ◽  
Neuropathic Pain Model ◽  
New Type ◽  
Anticholinesterase Drug

Neuromidin Attenuates Neuropathic Pain in the Streptozocin-Induced Diabetes Model in Rats Diabetic neuropathy, which affects all peripheral nerves and may cause dramatic pain, is one of the most severe pathologies associated with hyperglycaemia, damage in the blood vessels, and inflammation in nerves. Anticonvulsants and antidepressants are still the most commonly used options to manage diabetic neuropathy. However, to improve clinical benefit in the treatment of diabetic neuropathies, as well as to minimize side effects, search for a new type of drugs to protect/treat neuropathic pain is still important. The aim of this study was to investigate neuromidin (ipidacrine, amiridin, NIK-247), an anticholinesterase drug of tetrahydroaminoacridine series, in the streptozocin (STZ)-induced diabetic neuropathic pain model in rats. Neuromidin was administered per os at daily doses 0.3, 1.0 and 3.0 mg/kg for ten days. The dynamics in the development of hyperalgesia (pain threshold) was measured by algesimeter for five weeks. The data obtained show that neuromidin considerably protects the development of peripheral neuropathic pain caused by STZ. The most active dose was the lowest—0.3 mg/kg. Neuromidin did not affect STZ-hyperglycemia, nor the weight gain in animal groups. Neuromidin per se at the doses 0.3 and 1.0 mg/kg showed a short-term analgesic activity. The cholinergic mechanism of neuromidin may be considered as essential in attenuating of diabetic neuropathic pain; other mechanisms remain to be elucidated.

Role of spinal phosphatases in cannabinoid-induced antinociception in a rodent neuropathic pain model

2010 ◽  
Vol 11 (4) ◽  
pp. S28
Author(s):  
E. Romero-Sandoval ◽  
R. Landry ◽  
J. DeLeo
Keyword(s):  
Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model
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